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Keywords: membrane protein
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Articles
Biochem Soc Trans (2020) 48 (1): 25–37.
Published: 24 December 2019
...Robin A. Corey; Phillip J. Stansfeld; Mark S.P. Sansom Membranes are formed from a bilayer containing diverse lipid species with which membrane proteins interact. Integral, membrane proteins are embedded in this bilayer, where they interact with lipids from their surroundings, whilst peripheral...
Articles
Biochem Soc Trans (2016) 44 (3): 883–890.
Published: 09 June 2016
... The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . iron-binding protein magnetite nucleation magnetosome magnetotactic bacteria membrane protein...
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Biochem Soc Trans (2013) 41 (1): 185–190.
Published: 29 January 2013
... © The Authors Journal compilation © 2013 Biochemical Society 2013 detergent G-protein-coupled receptor membrane protein thermostability Determining the structures of proteins by X-ray diffraction relies on generating milligram quantities of pure, correctly folded material, which can...
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Biochem Soc Trans (2012) 40 (6): 1291–1294.
Published: 21 November 2012
... and functional mechanisms of this focal protein. Understanding the structure and function of membrane proteins is hampered by inherent difficulties associated with their purification since the choice of the detergents play a critical role in the protein structure and stability. In the present mini-review, we...
Articles
Biochem Soc Trans (2011) 39 (3): 747–750.
Published: 20 May 2011
...Gunnar von Heijne Membrane proteins currently receive a lot of attention, in large part thanks to a steady stream of high-resolution X-ray structures. Although the first few structures showed proteins composed of tightly packed bundles of very hydrophobic more or less straight transmembrane α...
Articles
Biochem Soc Trans (2011) 39 (3): 761–766.
Published: 20 May 2011
...Anthony G. Lee Intrinsic membrane proteins are solvated by a shell of lipid molecules interacting with the membrane-penetrating surface of the protein; these lipid molecules are referred to as annular lipids. Lipid molecules are also found bound between transmembrane α-helices; these are referred...
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Biochem Soc Trans (2011) 39 (3): 751–760.
Published: 20 May 2011
... of the intersubunit interactions of membrane protein complexes that contain both hydrophobic and hydrophilic subunits. In the present paper, we focus on the vitamin B 12 importer of Escherichia coli , BtuCD, that contains two transmembrane BtuC subunits and two ATP-binding BtuD subunits. We have studied the factors...
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Biochem Soc Trans (2011) 39 (3): 707–718.
Published: 20 May 2011
... 18 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 glutamate receptor hetero-oligomeric protein ionotropic receptor membrane protein N -methyl- D -aspartate receptor (NMDA receptor) tandem affinity purification-tagged mouse (TAP-tagged mouse...
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Biochem Soc Trans (2009) 37 (4): 643–652.
Published: 22 July 2009
...Paul Curnow Integral membrane proteins are important biological macromolecules with structural features and functionalities that make them attractive targets for nanotechnology. I provide here a broad review of current activity in nanotechnology related to membrane proteins, including...
Articles
Biochem Soc Trans (2009) 37 (2): 392–399.
Published: 20 March 2009
... Biochemical Society 2009 electron transfer haem-copper oxidase membrane protein nitric oxide nitrous oxide proton transfer Movement of protons to the dinuclear centre of HCuOs, which lies buried in the hydrophobic interior of the membrane, is via pathways formed by ionizable amino acid side...
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Biochem Soc Trans (2009) 37 (2): 400–407.
Published: 20 March 2009
... of the structure and mechanism of the purple bacterial RC, focusing in the main on the most heavily studied complex from Rhodobacter sphaeroides . 1 email m.r.jones@bristol.ac.uk 14 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 electron transfer membrane...
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Biochem Soc Trans (2008) 36 (6): 1169–1174.
Published: 19 November 2008
... Society 2008 electron transfer haem-copper oxidase membrane protein proton pump proton transfer redox reaction Cyt c O catalyses the oxidation of four molecules of cytochrome c and the reduction of O 2 to H 2 O ( eqn 1a ). The electrons are donated from the relatively positive ( P...
Articles
Biochem Soc Trans (2008) 36 (5): 996–1000.
Published: 19 September 2008
...C. Roy D. Lancaster; Elena Herzog; Hanno D. Juhnke; M. Gregor Madej; Florian G. Müller; Rajsekhar Paul; Philipp G. Schleidt Membrane protein complexes can support both the generation and utilization of a transmembrane electrochemical proton potential (Δ p ), either by supporting transmembrane...
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Biochem Soc Trans (2007) 35 (5): 835–847.
Published: 25 October 2007
... has provided a wealth of biochemical, biophysical and genetic data. In general, three types of integral membrane protein have been identified as components of the Tat translocase ( Figure 2 ): TatA (also called Tha4 and Tha9 in the plant chloroplast system), TatB (Hcf106 in plants), and TatC...
Articles
Biochem Soc Trans (2005) 33 (6): 1225–1230.
Published: 26 October 2005
... ]. membrane protein protein translocation secretion SecYEG translocon Polypeptide transport and import usually occurs when they are in an unfolded state. In rare cases, proteins that necessarily fold before their transport across a membrane are translocated by the so-called TAT (twin arginine...
Includes: Multimedia, Supplementary data
Articles
Biochem Soc Trans (2005) 33 (5): 1012–1015.
Published: 26 October 2005
...S.H. White; G. von Heijne Membrane-protein integration, folding and assembly processes in vivo depend on complex targeting, translocation, chaperoning, and sorting machineries that somehow read the ‘molecular code’ built into the nascent polypeptide, ultimately producing a properly folded protein...
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Biochem Soc Trans (2005) 33 (5): 924–930.
Published: 26 October 2005
... the binding of cofactors and the provision of structural support. The challenges of modelling surface-associated electron density features such as lipids, detergents, small amphiphiles and ions are discussed. © 2005 The Biochemical Society 2005 detergent lipid membrane protein protein engineering...
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Biochem Soc Trans (2005) 33 (5): 938–942.
Published: 26 October 2005
...C. Hunte Many membrane proteins selectively bind defined lipid species. This specificity has an impact on correct insertion, folding, structural integrity and full functionality of the protein. How are these different tasks achieved? Recent advances in structural research of membrane proteins...
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Biochem Soc Trans (2005) 33 (5): 910–912.
Published: 26 October 2005
...P.J. Bond; J. Cuthbertson; M.S.P. Sansom Interactions between membrane proteins and detergents are important in biophysical and structural studies and are also biologically relevant in the context of folding and transport. Despite a paucity of high-resolution data on protein–detergent interactions...
Articles
Biochem Soc Trans (2005) 33 (4): 851–857.
Published: 01 August 2005
.... Spectroscopic evidence has been presented that suggests that both cofactor branches catalyse membrane-spanning electron transfer in Type I reaction centres, although this may not universally be the case (see [ 24 – 27 ] and references therein). bacteriochlorophyll electron transfer membrane protein...
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Biochem Soc Trans (2004) 32 (6): 1122–1123.
Published: 26 October 2004
... (email WS.Gilmore@ulster.ac.uk ). 8 7 2004 © 2004 The Biochemical Society 2004 annexin differentiation haematopoiesis membrane protein Annexins are a family of homologous calcium-dependent proteins, named because of their ability to annex anionic phospholipid membranes [ 1...
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Biochem Soc Trans (2004) 32 (5): 659–662.
Published: 26 October 2004
...S. High; B.M. Abell The post-translational integration of tail-anchored proteins at the endoplasmic reticulum represents a novel and distinct pathway for membrane protein synthesis. Studies of various precursors, exemplified by the synaptobrevins and cytochrome b5 , indicate that multiple routes...
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Biochem Soc Trans (2004) 32 (5): 738–741.
Published: 26 October 2004
...: Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, 2-41-6 Aomi, Koto-ku, Tokyo 135-0064, Japan (email t-okada@aist.go.jp ). 17 6 2004 © 2004 The Biochemical Society 2004 crystal structure G-protein-coupled receptor membrane protein...
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Biochem Soc Trans (2004) 32 (6): 1130–1132.
Published: 26 October 2004
... 1 To whom correspondence should be addressed (email J.R.Sayers@sheffield.ac.uk ). 27 7 2004 host–pathogen interaction immunoglobulin A1 (IgA1) membrane protein protease translocation type V secretion Neisseria meningitidis and Haemophilus influenzae are responsible...
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Biochem Soc Trans (2004) 32 (3): 520–523.
Published: 01 June 2004
...: a Biochemical Society Focused Meeting held at Rothamsted Research, Harpenden, 25 November 2003 25 November 2003 © 2004 Biochemical Society 2004 Golgi isotope-coded affinity tag (ICAT) membrane protein organelle quantitative proteomics Abbreviations used: 2D, two-dimensional...
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Biochem Soc Trans (2002) 30 (4): 715–718.
Published: 01 August 2002
... © 2002 Biochemical Society 2002 heavy metal ion transport membrane protein mercuric ion resistance Biometals 2002: Third International Biometals Symposium: Focused Meeting Organized by S. Andrews (School of Animal and Microbial Sciences, University of Reading), R. Cammack, R. W...
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Biochem Soc Trans (2001) 29 (6): 732–736.
Published: 01 November 2001
...J. A. Schmid; H. Just; H. H. Sitte The formation of oligomeric structures has been proposed for a large number of membrane proteins, including G-protein-coupled receptors and ion channels. Biochemical studies employing gel filtration, cross-linking or co-immunoprecipitation techniques showed...
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Biochem Soc Trans (2001) 29 (4): 589–593.
Published: 01 August 2001
...P. I. Haris It is estimated that membrane proteins comprise as much as 30% of most genomes. Yet our knowledge of membrane-protein folding is still in its infancy. Consequently, there is a great need for developing approaches that can further advance our understanding of how peptides and proteins...
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Biochem Soc Trans (2001) 29 (4): 559–564.
Published: 01 August 2001
...J. D. Lear; H. Gratkowski; W. F. DeGrado Our current level of understanding of membrane-protein folding is primitive, but it is beginning to advance. Previously [Choma, Gratkowski, Lear and DeGrado (2000) Nat. Struct. Biol. 7, 161–166], we described studies of the association in detergent micelles...