... half-century. The study of dynamic processes such as membrane fusion and endocytosis is an example of this progress. Early studies have successfully detected vesicle exo- and endocytosis using fluorescent FM1–43 to label exocytic and endocytic vesicles ( Figure 1 ) [ 1 ], which represented the earliest...

... a key transition state in membrane fusion [ 99–102 ]; this can occur while the orientation of the whole bilayer and even the headgroup of the affected lipid remains intact [ 99 ]. As might be expected, the conformational state of the fusion peptide does affect the degree of lipid tail protrusion induced...

... ) * Equal contribution. 19 9 2019 12 11 2019 25 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 membrane fusion phospholipids protocell Before building protocells, cellular components, such as nucleic acids...

... in mast cells. We also discuss strategies to delineate these pathways so as to identify unique molecular components which could serve as new drug targets for more effective and specific treatments against mast cell-related diseases. degranulation exocytosis mast cell membrane fusion Munc18 SNARE...

... mechanisms of KNOLLE trafficking and interaction of KNOLLE with different soluble N -ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) partners and with SM-protein KEULE, ensuring membrane fusion in cytokinesis. 1 To whom correspondence should be addressed (email...

... of a complex between members of the t- (target) family of SNAREs and their cognate v- (vesicle) SNAREs is sufficient to drive membrane fusion, and SNAREs are also thought to contribute to the specificity of the trafficking event [ 7 ]. Thus regulation of SNARE complex formation provides one means by which...

... and transport of various cargoes within the cell. Much of our knowledge of membrane fusion derives from genetic approaches in yeast, protein-free synthetic membrane fusion systems and cell-free systems for identifying various components of the fusion machinery [ 9 , 10 ], including soluble N -ethylmaleimide...

... of palmitoylation sites and the fatty acid species bound to HA. Finally, the functional consequences of palmitoylation of HA and M2 are discussed regarding association with membrane rafts, entry of viruses into target cells by HA-mediated membrane fusion as well as the release of newly assembled virus particles...

... assembles at, and buds through, membrane areas that are enriched in tetraspanins CD9, CD63, CD81 and CD82, and (ii) the presence of these proteins at exit sites and in viral particles inhibits virus-induced membrane fusion. In the present paper, I review these findings and briefly discuss the results of our...

...Sascha Martens Neurotransmitter release is mediated by the fusion of synaptic vesicles with the presynaptic plasma membrane. Fusion is triggered by a rise in the intracellular calcium concentration and is dependent on the neuronal SNARE (soluble N -ethylmaleimide-sensitive fusion protein-attachment...

... The Authors Journal compilation © 2009 Biochemical Society 2009 evolution fungal soluble SNARE membrane fusion metazoan SNARE multicellularity vesicle trafficking The eukaryotic cell encompasses a large system of intracellular membrane-delimited compartments. It is widely assumed...

... dengue virus type 2 MD Molecular Dynamics sE soluble E References 1 Marsh M. The entry of enveloped viruses into cells by endocytosis Biochem. J. 1984 218 1 10 2 Stiasny K. Heinz F.X. Flavivirus membrane fusion J. Gen. Virol. 2006 87 2755 2766...