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Keywords: melanoma
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Biochem Soc Trans (2015) 43 (5): 1085–1088.
Published: 09 October 2015
... that TRIB2 can also act as oncogenic driver in solid tumours, such as lung and liver cancer. In particular, our recent work demonstrated that TRIB2 is dramatically overexpressed in malignant melanomas compared with normal skin and promotes the malignant phenotype of melanoma cells via the down-regulation...
Biochem Soc Trans (2014) 42 (5): 1356–1366.
Published: 18 September 2014
... migration in response to widely used in vitro collagen-based substrates, including a continuous 2D surface, discontinuous fibril-based surfaces (2.5D) and fibril-based 3D geometries. Migrating B16F1 mouse melanoma cells expressing GFP–actin developed striking diversity and adaptation of cytoskeletal...
Includes: Supplementary data
Biochem Soc Trans (2014) 42 (4): 727–732.
Published: 11 August 2014
...Claudia Wellbrock The serine threonine kinases BRAF and MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] are major regulators of the ERK/MAPK pathway, which is deregulated in the majority of melanomas. Targeting BRAF is an effective therapy...
Biochem Soc Trans (2007) 35 (5): 1377–1378.
Published: 25 October 2007
... that lycopene inhibited PDGF-BB (platelet-derived growth factor-BB)-induced signalling and cell migration in human cultured skin fibroblasts through a novel mechanism of action, i.e. direct binding to PDGF-BB. Trapping of PDGF by lycopene also compromised melanoma-induced fibroblast migration and attenuated...