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Keywords: mechanotransduction
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Biochem Soc Trans (2024) BST20221194.
Published: 04 April 2024
... which could lead to synchronisation of the whole cell. A signal entering the cell updates the whole cytoskeletal organisation and the interconnected binary switches distributed throughout the cell will be updated with this new information. Mechanotransduction, how mechanical signals are transmitted...
Biochem Soc Trans (2023) 51 (5): 1897–1906.
Published: 29 September 2023
...Delfine Cheng; Junfan Wang; Mingxi Yao; Charles D Cox Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as PIEZO1 are critical in mechanotransduction processes that influence cell differentiation, development, and cancer. Ample evidence now exists for regulatory...
Biochem Soc Trans (2023) 51 (3): 1331–1345.
Published: 12 May 2023
... Attribution License 4.0 (CC BY) . DCM and EDMD mechanotransduction microtubule nesprin nuclear envelope LINC complex nuclear positioning The nuclear envelope (NE) is a highly dynamic organelle providing spatial separation of the nuclear and cytoplasmic environments and protecting the genome...
Biochem Soc Trans (2019) 47 (6): 1833–1842.
Published: 22 November 2019
... ) or Charles D. Cox ( C.Cox@victorchang.edu.au ) 20 9 2019 28 10 2019 1 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 amphipaths channel domains mechanotransduction PIEZO channels Based on molecular dynamic...
Biochem Soc Trans (2016) 44 (5): 1549–1560.
Published: 19 October 2016
... melanogaster heart failure integrins mechanical forces mechanotransduction Heart disease is a major cause of mortality in modern society [ 1 , 2 ]. Chronic heart failure (HF) represents 8% of the disease population [ 3 ], and more than 70% of which had a history of arterial hypertension and 25...
Biochem Soc Trans (2014) 42 (3): 645–649.
Published: 22 May 2014
... cells, keratinocytes, mammary epithelial cells and smooth muscle cells. In addition, recent evidence suggests a potential role for β-catenin and Smad signalling in mechanotransduction, but further mechanistic studies are needed to prove this hypothesis. As a model system, the epidermis of the skin...
Biochem Soc Trans (2011) 39 (6): 1633–1638.
Published: 21 November 2011
... alter their morphology, function and gene expression. The molecular basis for mechanotransduction of a shear stress signal, and the identity of the sensing mechanisms, remain unclear with many candidates under investigation. Translating these findings in vivo has proved difficult. The role of VEGF...
Biochem Soc Trans (2007) 35 (5): 1312–1313.
Published: 25 October 2007
... in mechanotransduction in intact muscle. © The Authors Journal compilation © 2007 Biochemical Society 2007 focal adhesion kinase (FAK) mechanobiology mechanotransduction phosphorylation striated muscle Mechanical factors exert a key influence on the phenotype of striated muscle [ 1 ]. This control...
Biochem Soc Trans (2007) 35 (4): 683–685.
Published: 20 July 2007
... there are limited studies to date, this paper aims to review current knowledge on F-actin cytoskeletal element organization in intervertebral disc cells, how F-actin differs with pathology and its implications for mechanotransduction. 30 3 2007 © The Authors Journal compilation © 2007 Biochemical...
Biochem Soc Trans (2007) 35 (1): 124–128.
Published: 22 January 2007
.... In addition, each TRP channel family has its own unique set of domains and motifs in the N- or C-terminus. calcium channel mechanotransduction polycystic kidney disease polycystin-1 primary cilium transient receptor potential (TRP) © 2007 The Biochemical Society 2007 17 8 2006...
Biochem Soc Trans (2002) 30 (6): 879–882.
Published: 01 November 2002
... actin cytoskeleton cyclic compression gelatin zymography mechanotransduction quantitative PCR MMP, matrix metalloproteinase GAPDH, glyceraldehyde-3-phosphate dehydrogenase Connective Tissue Research Colloquium Organized and Edited by V. Duance (School of Biosciences, Cardiff University...