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Keywords: mass spectrometry
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Articles
Biochem Soc Trans (2022) 50 (3): 1057–1067.
Published: 13 June 2022
... for the analytical tools used to investigate these systems of increased size and complexity, such as Native Mass Spectrometry, which has always been an important tool for structural biology. Scientific advance and recent developments, such as new ways to mimic a cell membrane for a membrane protein, have caused...
Articles
Biochem Soc Trans (2022) 50 (1): 347–359.
Published: 23 December 2021
... structures of VP1 protruding domain dimers, so called P-dimers, complexed with different HBGAs have been solved to atomic resolution. Corresponding binding affinities have been determined for HBGAs and other glycans exploiting different biophysical techniques, with mass spectrometry (MS) and nuclear magnetic...
Articles
Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
... interactors. Recent advances in mapping direct interactors of histone PTMs as well as local chromatin interactomes will be highlighted, with a focus on mass-spectrometry based workflows that continue to illuminate histone-mediated PPIs in unprecedented detail. 1 9 2021 5 10 2021 6 10 2021...
Articles
Biochem Soc Trans (2021) 49 (4): 1643–1662.
Published: 20 July 2021
...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. glycobiology glycomics glycoproteomics mass spectrometry multi-omics proteomics Protein post-translational modifications (PTMs) enable the cell to produce...
Articles
Biochem Soc Trans (2021) 49 (3): 1241–1250.
Published: 07 May 2021
... have been characterised in detail by a range of mass spectrometry techniques, including direct infusion and liquid chromatography mass spectrometry, there are relatively few reports of comprehensive analyses of oxidised phospholipids in disease states. Oxidised phospholipid species are widely thought...
Articles
Biochem Soc Trans (2021) 49 (1): 55–69.
Published: 25 January 2021
...Kay-Hooi Khoo The nature of protein glycosylation renders cellular glycomics a very challenging task in having to deal with all the disparate glycans carried on membrane glycoproteins. Rapid mapping by mass spectrometry analysis provides only a coarse sketch of the glycomic complexity based...
Articles
Biochem Soc Trans (2021) 49 (1): 161–186.
Published: 13 January 2021
...Anastasia Chernykh; Rebeca Kawahara; Morten Thaysen-Andersen Facilitated by advances in the separation sciences, mass spectrometry and informatics, glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling new insights into the complex glycoproteome. While...
Articles
Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
...Charles Eldrid; Konstantinos Thalassinos Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which...
Articles
Biochem Soc Trans (2020) 48 (5): 1953–1966.
Published: 20 October 2020
...Lindsay K. Pino; Jacob Rose; Amy O'Broin; Samah Shah; Birgit Schilling Research into the basic biology of human health and disease, as well as translational human research and clinical applications, all benefit from the growing accessibility and versatility of mass spectrometry (MS)-based...
Articles
Biochem Soc Trans (2020) 48 (3): 945–954.
Published: 15 May 2020
...Lisa M. Jones Mass spectrometry (MS) has long been used to study proteins mainly via sequence identification and quantitation of expression abundance. In recent years, MS has emerged as a tool for structural biology. Intact protein structural analysis has been enabled by the development of methods...
Articles
Biochem Soc Trans (2020) 48 (1): 317–326.
Published: 03 February 2020
... analysis, desorption electrospray ionisation and nanospray desorption electrospray ionisation. Similarly, developments in native mass spectrometry allow protein–protein and protein–ligand complexes to be ionised and analysed. Identification and characterisation of these large ions involves a suite...
Articles
Biochem Soc Trans (2019) 47 (1): 317–327.
Published: 15 January 2019
...Timothy M. Allison; Cherine Bechara Mass spectrometry (MS) provides an impressive array of information about the structure, function and interactions of proteins. In recent years, many new developments have been in the field of native MS and these exemplify a new coming of age of this field...
Articles
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
..., autoimmunity and neurodegeneration, demonstrating the importance of ubiquitylation. Therefore, enzymes of the ubiquitin system are considered highly attractive drug targets. In recent years, mass spectrometry (MS)-based techniques have become increasingly important in the deciphering of the ubiquitin system...
Articles
Biochem Soc Trans (2017) 45 (1): 251–260.
Published: 15 February 2017
... and models derived from mass spectrometry (MS) datasets were correct. With recent advances in structure determination, many of the most challenging complexes that we studied over the years have become tractable by other structural biology approaches enabling such comparisons to be made. Moreover...
Articles
Biochem Soc Trans (2015) 43 (5): 983–994.
Published: 09 October 2015
... with mass spectrometry (MS) (XF–MS), which provide residue-specific information on the solvent accessibility of proteins. In combination with both low- and high-resolution data from other structural biology approaches, it is capable of providing valuable insights into dynamics of membrane proteins, which...
Articles
Biochem Soc Trans (2014) 42 (6): 1698–1703.
Published: 17 November 2014
.... Moonlighting proteins Trends Biochem. Sci. 1999 24 8 11 10.1016/S0968-0004(98)01335-8 10087914 2 Jeffery C.J. Mass spectrometry and the search for moonlighting proteins Mass Spectrom. Rev. 2005 24 772 782 10.1002/mas.20041 15605385 3 Jeffery C.J. Moonlighting proteins...
Articles
Biochem Soc Trans (2014) 42 (4): 791–797.
Published: 11 August 2014
... for Activiomics Ltd. 2 To whom correspondence should be addressed (email p.cutillas@qmul.ac.uk ). 21 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 acquired resistance cancer mass spectrometry phosphoproteomics signalling plasticity systems biology...
Articles
Biochem Soc Trans (2014) 42 (4): 1107–1111.
Published: 11 August 2014
...-review discusses methods that are commonly used to measure CoA species in biological samples. 30 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 coenzyme A enzymatic assay HPLC mass spectrometry unesterified coenzyme A (CoASH) Since the discovery...
Articles
Biochem Soc Trans (2014) 42 (4): 837–845.
Published: 11 August 2014
... by careful attention to the analytical workflow. 1 To whom correspondence should be addressed (email r.beynon@liv.ac.uk ). 12 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 major urinary protein (MUP) mass spectrometry stable isotope QconCAT...
Articles
Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
... © The Authors Journal compilation © 2014 Biochemical Society 2014 dicarbonyl stress glycation mass spectrometry methylglyoxal 3-nitrotyrosine oxidative stress 8-oxodeoxyguanosine Proteins in physiological systems undergo continual spontaneous modification by glycating agents...
Articles
Biochem Soc Trans (2014) 42 (2): 450–456.
Published: 20 March 2014
... email Paul.J.Beisswenger@Dartmouth.edu 10 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 advanced glycation end-product (AGE) diabetic complication glycaemic fluctuation mass spectrometry metformin methylglyoxal The present review discusses...
Articles
Biochem Soc Trans (2014) 42 (1): 145–150.
Published: 23 January 2014
... spectrometry (HDX-MS) mass spectrometry protein dynamics protein kinase HDX-MS (hydrogen–deuterium exchange coupled to MS) on biomolecules relies on the propensity of hydrogen atoms bound to nitrogen and oxygen heteroatoms in a biomolecule to readily exchange with solvent. In the context...
Articles
Biochem Soc Trans (2013) 41 (4): 1089–1095.
Published: 18 July 2013
... Society 2013 histidine mass spectrometry phosphate transfer phosphohistidine phosphorylation proteomics In prokaryotes, fungi and plants, histidine kinase function is well documented. Targeted analyses in these organisms have demonstrated that autophosphorylation of transmembrane...
Articles
Biochem Soc Trans (2011) 39 (5): 1334–1340.
Published: 21 September 2011
... Society 2011 congenital disorder of glycosylation congenital neutropenia glycogen storage disease 1b (GSD 1b) mass spectrometry matrix-assisted laser-desorption ionization–time-of-flight (MALDI–TOF) N-glycan Glycans attached to proteins and lipids on the surfaces of immune cells serve...
Articles
Biochem Soc Trans (2011) 39 (5): 1217–1220.
Published: 21 September 2011
... area. 1 To whom correspondence should be addressed (email paul.winyard@pms.ac.uk ). 19 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 biomolecular damage cell signalling fluorescence free radical mass spectrometry measurement The present...
Articles
Biochem Soc Trans (2011) 39 (5): 1348–1352.
Published: 21 September 2011
...@mail.shchc.ac.cn ). 29 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 mass spectrometry proteomics systems biology traditional Chinese medicine two-dimensional protein electrophoresis With a history of more than 2000 years, TCM (traditional Chinese medicine...
Articles
Biochem Soc Trans (2011) 39 (5): 1260–1267.
Published: 21 September 2011
... should be addressed (email philip.eaton@kcl.ac.uk ). 21 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 alkylating agent dibromobimane (DBB) glutaredoxin (Grx) mass spectrometry thiol oxidation thioredoxin (Trx) Figure 1 Reactive protein...
Articles
Biochem Soc Trans (2011) 39 (5): 1233–1239.
Published: 21 September 2011
... c.m.spickett@aston.ac.uk ). 24 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 chlorinated phospholipid inflammation mass spectrometry oxidized phospholipid (oxPL) precursor ion scanning Toll-like receptor (TLR) The interest in lipids as mediators...
Articles
Biochem Soc Trans (2011) 39 (5): 1240–1246.
Published: 21 September 2011
... lipoxygenase (LOX) mass spectrometry polyunsaturated fatty acid (PUFA) Recent advances in MS have underpinned the development of lipidomics, allowing the simultaneous qualitative and quantitative assessment of numerous lipid species through one experimental protocol [ 5 – 8 ]. In particular, mediator...
Articles
Biochem Soc Trans (2010) 38 (5): 1307–1313.
Published: 24 September 2010
... of the characteristic signature oxonium ion ( m / z 229) for DATDH. bacterium flagellin glycoproteomics glycosylation mass spectrometry pilin © The Authors Journal compilation © 2010 Biochemical Society 2010 14 12 2009 1 To whom correspondence should be addressed (email a.dell...
Articles
Biochem Soc Trans (2010) 38 (4): 883–887.
Published: 26 July 2010
...@iri.univ-lille1.fr ). 16 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 interaction proteomics mass spectrometry protein complex tandem affinity purification By dramatically reducing the levels of background proteins in the purifications, TAP...
Articles
Biochem Soc Trans (2009) 37 (4): 905–909.
Published: 22 July 2009
... © The Authors Journal compilation © 2009 Biochemical Society 2009 desorption/ionization on silicon (DIOS) laser desorption mass spectrometry matrix-assisted laser-desorption ionization (MALDI) surface-assisted laser-desorption ionization (SALDI) Biological systems, particularly...
Articles
Biochem Soc Trans (2007) 35 (5): 1064–1068.
Published: 25 October 2007
... the decreased magnitude of the AP-induced shift in electrophoretic mobility in C-, but not N-, terminal truncation and deletion mutants, consistent with the C-terminus of Kv2.1 acting as the major substrate for phosphorylation. calcineurin electrical signalling ion channel mass spectrometry...
Articles
Biochem Soc Trans (2006) 34 (2): 251–256.
Published: 20 March 2006
... The Biochemical Society 2006 antimicrobial peptide defensin mass spectrometry The mammalian innate immune system produces a large array of weapons to protect the host from the constant attack which it is under from micro-organisms [ 1 ]. One important family is the cationic AMPs (antimicrobial...
Articles
Biochem Soc Trans (2003) 31 (6): 1476–1478.
Published: 01 December 2003
... 2003 22 July 2003 © 2003 Biochemical Society 2003 data mining mass spectrometry metabolic networks metabolomics 1476 Biochemical Society Transactions (2003) Volume 31, part 6 Interpreting correlations in metabolomic networks R. Steuer*1, J. Kurths*, O. Fiehn and W. Weckwerth...
Articles
Biochem Soc Trans (2003) 31 (4): 810–814.
Published: 01 August 2003
... particles and chemicals, that Key words: epoxy chemical, lipopolysaccharide, mass spectrometry, nasal lavage fluid, PLUNC (palate, lung and nasal epithelial clone), two-dimensional gel electrophoresis. Abbreviations used: 2-DE, two-dimensional gel electrophoresis; DMBA, dimethylbenzylamine; LPS...
Articles
Biochem Soc Trans (2002) 30 (2): 82–87.
Published: 01 April 2002
...@ciphergen.com 19 11 2001 © 2002 Biochemical Society 2002 2-DE, two-dimensional protein gel electrophoresis Qq, quadropole-quadropole SELDI, surface-enhanced laser desorption/ionization TCC, transitional cell carcinoma TOF-MS, time-of-flight MS biomarker mass spectrometry protein...