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Keywords: mass spectrometry
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Biochem Soc Trans (2024) 52 (2): 627–637.
Published: 04 April 2024
... of this ubiquitination modification. Despite many biochemical or proteomic approaches available for ubiquitination detection, mass-spectrometry stood out to be the most efficient and transformative technology to read this complex modification script. Here in this review, we have discussed how different ubiquitin codes...
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Biochem Soc Trans (2022) 50 (6): 1569–1582.
Published: 01 December 2022
..., but no information on its affinity for other C-18 species has been reported [ 42 ]. bioactive lipid linoleic acid lipid mediators mass spectrometry octadecanoid Oxylipins are broadly defined as enzymatic metabolites of mono- or polyunsaturated fatty acids (PUFAs) produced by at least one step...
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Biochem Soc Trans (2022) 50 (3): 1057–1067.
Published: 13 June 2022
... for the analytical tools used to investigate these systems of increased size and complexity, such as Native Mass Spectrometry, which has always been an important tool for structural biology. Scientific advance and recent developments, such as new ways to mimic a cell membrane for a membrane protein, have caused...
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Biochem Soc Trans (2022) 50 (1): 347–359.
Published: 23 December 2021
... structures of VP1 protruding domain dimers, so called P-dimers, complexed with different HBGAs have been solved to atomic resolution. Corresponding binding affinities have been determined for HBGAs and other glycans exploiting different biophysical techniques, with mass spectrometry (MS) and nuclear magnetic...
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Biochem Soc Trans (2021) 49 (5): 2431–2441.
Published: 28 October 2021
... interactors. Recent advances in mapping direct interactors of histone PTMs as well as local chromatin interactomes will be highlighted, with a focus on mass-spectrometry based workflows that continue to illuminate histone-mediated PPIs in unprecedented detail. Correspondence: Antony J. Burton...
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Biochem Soc Trans (2021) 49 (4): 1643–1662.
Published: 20 July 2021
...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. glycobiology glycomics glycoproteomics mass spectrometry multi-omics proteomics Protein post-translational modifications (PTMs) enable the cell to produce...
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Biochem Soc Trans (2021) 49 (3): 1241–1250.
Published: 07 May 2021
... have been characterised in detail by a range of mass spectrometry techniques, including direct infusion and liquid chromatography mass spectrometry, there are relatively few reports of comprehensive analyses of oxidised phospholipids in disease states. Oxidised phospholipid species are widely thought...
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Biochem Soc Trans (2021) 49 (1): 161–186.
Published: 13 January 2021
...Anastasia Chernykh; Rebeca Kawahara; Morten Thaysen-Andersen Facilitated by advances in the separation sciences, mass spectrometry and informatics, glycoproteomics, the analysis of intact glycopeptides at scale, has recently matured enabling new insights into the complex glycoproteome. While...
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Biochem Soc Trans (2020) 48 (6): 2457–2466.
Published: 18 December 2020
...Charles Eldrid; Konstantinos Thalassinos Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a combination of m/z and molecular shape. While tandem MS instruments are common, instruments which...
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Biochem Soc Trans (2020) 48 (3): 945–954.
Published: 15 May 2020
...Lisa M. Jones Mass spectrometry (MS) has long been used to study proteins mainly via sequence identification and quantitation of expression abundance. In recent years, MS has emerged as a tool for structural biology. Intact protein structural analysis has been enabled by the development of methods...
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Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
..., autoimmunity and neurodegeneration, demonstrating the importance of ubiquitylation. Therefore, enzymes of the ubiquitin system are considered highly attractive drug targets. In recent years, mass spectrometry (MS)-based techniques have become increasingly important in the deciphering of the ubiquitin system...
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Biochem Soc Trans (2017) 45 (1): 251–260.
Published: 15 February 2017
... and models derived from mass spectrometry (MS) datasets were correct. With recent advances in structure determination, many of the most challenging complexes that we studied over the years have become tractable by other structural biology approaches enabling such comparisons to be made. Moreover...
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Biochem Soc Trans (2015) 43 (5): 983–994.
Published: 09 October 2015
... with mass spectrometry (MS) (XF–MS), which provide residue-specific information on the solvent accessibility of proteins. In combination with both low- and high-resolution data from other structural biology approaches, it is capable of providing valuable insights into dynamics of membrane proteins, which...
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Biochem Soc Trans (2014) 42 (6): 1698–1703.
Published: 17 November 2014
... for analytical protein science [ 6 – 8 ]. 1 To whom correspondence should be addressed (email r.beynon@liv.ac.uk ). 13 10 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 bottom-up mass spectrometry protein moonlighting proteomics QconCAT top-down...
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Biochem Soc Trans (2014) 42 (4): 1107–1111.
Published: 11 August 2014
... A enzymatic assay HPLC mass spectrometry unesterified coenzyme A (CoASH) Since the discovery of CoA (coenzyme A) by Fritz Lipmann over 60 years ago, various methods have been developed to isolate and measure CoA and its thioester derivatives to study their biological functions. Early methods...
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Biochem Soc Trans (2014) 42 (4): 791–797.
Published: 11 August 2014
... for Activiomics Ltd. 2 To whom correspondence should be addressed (email p.cutillas@qmul.ac.uk ). 21 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 acquired resistance cancer mass spectrometry phosphoproteomics signalling plasticity systems biology...
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Biochem Soc Trans (2014) 42 (4): 837–845.
Published: 11 August 2014
... by careful attention to the analytical workflow. 1 To whom correspondence should be addressed (email r.beynon@liv.ac.uk ). 12 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 major urinary protein (MUP) mass spectrometry stable isotope QconCAT...
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Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
... (BIOCLAIMS Project)]. References 1 Rabbani N. Thornalley P.J. Glycation research in amino acids: a place to call home Amino Acids 2012 42 1087 1096 2 Thornalley P.J. Rabbani N. Detection of oxidized and glycated proteins in clinical samples using mass spectrometry...
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Biochem Soc Trans (2014) 42 (2): 450–456.
Published: 20 March 2014
... ]; and (iv) is a major cause of CVD (cardiovascular disease) [ 3 ]. advanced glycation end-product (AGE) diabetic complication glycaemic fluctuation mass spectrometry metformin methylglyoxal On the basis of the current incidence of diabetes and demographics, it has been projected...
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Biochem Soc Trans (2014) 42 (1): 145–150.
Published: 23 January 2014
... of the αE helix are more protected compared with the unbound form of CSK. hydrogen–deuterium exchange coupled to mass spectrometry (HDX-MS) mass spectrometry protein dynamics protein kinase HDX-MS (hydrogen–deuterium exchange coupled to MS) on biomolecules relies on the propensity...
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Biochem Soc Trans (2013) 41 (4): 1089–1095.
Published: 18 July 2013
... phosphorylation. 1 These authors contributed equally to this paper. 2 To whom correspondence should be addressed (email Claire.Eyers@Liverpool.ac.uk ). 1 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 histidine mass spectrometry phosphate...
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Biochem Soc Trans (2011) 39 (5): 1348–1352.
Published: 21 September 2011
...@mail.shchc.ac.cn ). 29 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 mass spectrometry proteomics systems biology traditional Chinese medicine two-dimensional protein electrophoresis In conclusion, application of proteomics in TCM studies is still...
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Biochem Soc Trans (2011) 39 (5): 1240–1246.
Published: 21 September 2011
... lipoxygenase (LOX) mass spectrometry polyunsaturated fatty acid (PUFA) Figure 1 Schematic overview of the enzymatic and non-enzymatic reactions mediating the production of oxygenated lipid mediators from AA FLAP, 5-lipoxygenase-activating protein. Recent advances in MS have underpinned...
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Biochem Soc Trans (2011) 39 (5): 1334–1340.
Published: 21 September 2011
... Society 2011 congenital disorder of glycosylation congenital neutropenia glycogen storage disease 1b (GSD 1b) mass spectrometry matrix-assisted laser-desorption ionization–time-of-flight (MALDI–TOF) N-glycan Glycans attached to proteins and lipids on the surfaces of immune cells...
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Biochem Soc Trans (2011) 39 (5): 1260–1267.
Published: 21 September 2011
... should be addressed (email philip.eaton@kcl.ac.uk ). 21 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 alkylating agent dibromobimane (DBB) glutaredoxin (Grx) mass spectrometry thiol oxidation thioredoxin (Trx) Cellular proteins can undergo...
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Biochem Soc Trans (2009) 37 (4): 905–909.
Published: 22 July 2009
... cancer and what can really be termed a safe level of radiation. © The Authors Journal compilation © 2009 Biochemical Society 2009 desorption/ionization on silicon (DIOS) laser desorption mass spectrometry matrix-assisted laser-desorption ionization (MALDI) surface-assisted laser-desorption...
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Biochem Soc Trans (2007) 35 (5): 1064–1068.
Published: 25 October 2007
... strategies may prove effective in defining the mechanisms underlying dynamic regulation of neuronal function under normal and pathological conditions. calcineurin electrical signalling ion channel mass spectrometry neuron protein kinase Protein phosphorylation constitutes one of the major...
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Biochem Soc Trans (2006) 34 (2): 251–256.
Published: 20 March 2006
... correspondence should be addressed (email Dominic.Campopiano@ed.ac.uk ). 13 1 2006 © 2006 The Biochemical Society 2006 antimicrobial peptide defensin mass spectrometry The mammalian innate immune system produces a large array of weapons to protect the host from the constant attack...
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Biochem Soc Trans (2003) 31 (6): 1476–1478.
Published: 01 December 2003
... 2003 22 July 2003 © 2003 Biochemical Society 2003 data mining mass spectrometry metabolic networks metabolomics 1476 Biochemical Society Transactions (2003) Volume 31, part 6 Interpreting correlations in metabolomic networks R. Steuer*1, J. Kurths*, O. Fiehn and W. Weckwerth...
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Biochem Soc Trans (2003) 31 (4): 810–814.
Published: 01 August 2003
... particles and chemicals, that Key words: epoxy chemical, lipopolysaccharide, mass spectrometry, nasal lavage fluid, PLUNC (palate, lung and nasal epithelial clone), two-dimensional gel electrophoresis. Abbreviations used: 2-DE, two-dimensional gel electrophoresis; DMBA, dimethylbenzylamine; LPS...
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