...Adrián Povo-Retana; Rodrigo Landauro-Vera; Marco Fariñas; Sergio Sánchez-García; Carlota Alvarez-Lucena; Silvia Marin; Marta Cascante; Lisardo Boscá Macrophages are essential components of the innate immune system that play both homeostatic roles in healthy organs, and host defence functions...

... in macrophages. Macrophages are front-line cellular defenders against endogenous and exogenous threats in mammals. These cells use an array of receptors and downstream signalling molecules to respond to a diverse range of stimuli, with mitochondrial biology implicated in many of these responses. Mitochondria...

... such as macrophages has yet to be fully explored. This review aims to highlight the benefits of 3D cell culturing for greater understanding of macrophage biology. We review current knowledge of macrophage interactions with their tissue microenvironment and highlight the potential of 3D macrophage models...

... are major and worldwide health and economic burdens. Macrophage accumulation within plaques is characteristic of all stages of atherosclerosis and their presence is a potential marker of disease activity and plaque stability. Macrophages engulf lipids and modified lipoproteins to form foam cells...

...Kristian H. Rasmussen; Clare L. Hawkins Macrophages play an integral role in initiating innate immune defences and regulating inflammation. They are also involved in maintaining homeostasis and the resolution of inflammation, by promoting tissue repair and wound healing. There is evidence that like...

... fibroblasts inflammation macrophages myocardial infarction Correspondence: Merry L. Lindsey ( Merry.Lindsey@unmc.edu ) 8 9 2019 22 10 2019 24 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 In addition...

... Torr , E.E. , Gardner , D.H. , Thomas , L. , Goodall , D.M. , Bielemeier , A. , Willetts , R. et al. ( 2012 ) Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells . Cell Death Differ. 19 , 671 – 679 10.1038/cdd...

... function of LRRK2 protein remains largely elusive, increasing evidence suggests that it plays a role in innate immunity, a process that also has been implicated in neurodegenerative diseases, including PD. Innate immunity involves macrophages and microglia, in which endogenous LRRK2 expression is precisely...