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![The catalytic structure of [FeFe] and [NiFe]-hydrogenases. (a) The archite...](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/pap/10.1042_bst20230120/2/s_bst-2023-0120c.01.png?Expires=2147483647&Signature=EkhYaW2F71DKMg20a9DHIJK3RYHy-kMWBbMl2MiS5EWl-pVrSyY-P6x52T4sz6YZ9OEl3zrWslGMlV8R8KIvaAlpayfrkVDNHY4seX9WcXi5sXz3Y~tucQAskqgaJJmjmt1hObCaCCSZOMIHz~8Jl2hmQsYqo3W2Hm3LBarqk1tUz0Zi7imtOlyoFnTakL09hpWwCeWmEJGMtZm6vKNIgaA~BpcxJB2cZLIAm12zVMaDZsOoavSZXChBxWY3kRtqgtgUIFwIJ92ZasfFS41zhteV6~ZrN3PD8h5tCGYhFjejpZWMKCgSlD41kf5i3wZCx0E2yC6AF3RH1LdKl~S6lw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
![The application of [NiFe]-hydrogenases in fuel cell development. ( a ) A s...](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/pap/10.1042_bst20230120/2/s_bst-2023-0120c.02.png?Expires=2147483647&Signature=gkeshkd90tl2MwQ4J4lpkql6-aR4h~O8MApC~vT9yNriCGFCUTeZMgX3wgNSFcRatDzmn5p1tyBKlMWyHeBHXsayw5oM3JVP~PmRxUZ4eqQ-ozZoFpSq5yK3pJKf6VHn37aT5jLYVkRSz6Z-SGp9oI7nYUyx7f3pbvBEZ9WB7scMnH7xtojEYEBoB383Jp8p15jPTDKMc1xce5i57Ni4iltGQXD~Wx~NvLmPZZEXvFzEAGBJWQI3zwl5YSQiRaQokseOvZjNKxoQFMSXFP5QMgXPmI8tsY3ev0oO58GxoIqpd6VvMBdWDDEidBcYLcLwWvenOX-SsDF75rwmteosOg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
![The structure of the [NiFe]-hydrogenase core catalytic complex. The struct...](https://port.silverchair-cdn.com/port/content_public/journal/biochemsoctrans/pap/10.1042_bst20230120/2/s_bst-2023-0120c.03.png?Expires=2147483647&Signature=UaixNVP~tgfs8nT0iIIqCq6wGFXAOS6xGNZplyO0lqdk9KZY0Fl-dopSNdi56dFSMTmfiW8d20VUc6yVLglnYk0zRXVds6lJXPbdTNW0JftuGS4pknItjZDhhfQhF4T~FR5kMIcFvEpL5~eJnSrQLibIh4~QAIhQlGTJc8MNCay5cxUw~d8Y6chLYDx2iOOiXhttDsq8AYYkxxhq4jyns~tbRJrU7iEau~mt~TlQ2rhhZ9ouhr4r5OUuAcuAVlSlAnNnrlPAo7A4HIVRkB59cl8b81l5Y7Vb6w~Iw9j-jfeo8tyie~ttUWdbhbVCWJywRl296OzG7SKnlJ2uUiuXDg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230532.
Published: 03 October 2023
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20220741.
Published: 03 October 2023
Images
in Adapting enzymes to improve their functionality in plants: why and how
> Biochemical Society Transactions
Published: 03 October 2023
Figure 1. Comparison of classical and continuous directed evolution. ( A ) Classical directed evolution makes mutations (red lines) to the target gene (blue arc) in vitro , screens or selects in vivo , then re-enters improved variants into the cycle. Each step requires manual intervention. ( B ... More about this image found in Comparison of classical and continuous directed evolution. ( A ) Classical...
Images
in Adapting enzymes to improve their functionality in plants: why and how
> Biochemical Society Transactions
Published: 03 October 2023
Figure 2. The yeast OrthoRep continuous directed evolution system. In OrthoRep, a nuclear plasmid-borne DNA polymerase engineered to have a high error rate specifically hypermutates a target gene of interest (GOI), inserted behind a suitable promoter (Prom) on the p1 linear cytoplasmic plasmid. T... More about this image found in The yeast OrthoRep continuous directed evolution system. In OrthoRep, a nu...
Images
in Adapting enzymes to improve their functionality in plants: why and how
> Biochemical Society Transactions
Published: 03 October 2023
Figure 3. Mapping what directed evolution can do onto what breeding programs need. The left-hand circle shows how fruit and vegetable breeding programs work to balance multiple traits simultaneously, that they prefer highly heritable traits that can be screened quickly and cheaply, and that the m... More about this image found in Mapping what directed evolution can do onto what breeding programs need. T...
Images
in How to fix DNA breaks: new insights into the mechanism of non-homologous end joining
> Biochemical Society Transactions
Published: 03 October 2023
Figure 1. Architecture of DNA-PKcs. ( A ) Schematic of DNA-PKcs showing the location of the N-HEAT, M-HEAT, FAT, kinase and FAT-C domains as described in [ 26 ]. Also shown is the location of the ABCDE phosphorylation site cluster (residues 2609–2647), the forehead domain (residues 892–1289), the... More about this image found in Architecture of DNA-PKcs. ( A ) Schematic of DNA-PKcs showing the location...
Images
in How to fix DNA breaks: new insights into the mechanism of non-homologous end joining
> Biochemical Society Transactions
Published: 03 October 2023
Figure 2. Architecture of the LR complex. ( A ) Structure of the LR complex from [ 51 ] with DNA-PKcs colored as in Figure 1A . Ku70 and 80 are in pink and lavender, XRCC4 in light blue, XLF in gray and the tandem BRCT domain of DNA-ligase IV is in light blue. The dsDNA is in turquoise. This uni... More about this image found in Architecture of the LR complex. ( A ) Structure of the LR complex from [ 5...
Images
in How to fix DNA breaks: new insights into the mechanism of non-homologous end joining
> Biochemical Society Transactions
Published: 03 October 2023
Figure 3. Architecture of the LR-ATP state. ( A ) Structure of the LR-ATP complex from [ 58 ], colored as in Figure 1A , showing the outward rotation of DNA-PKcs, the inward rotation of Ku70/80 and the new interaction of the two NUC194 domains. The structure on the right is rotated by 90°. ( B )... More about this image found in Architecture of the LR-ATP state. ( A ) Structure of the LR-ATP complex fr...
Images
in How to fix DNA breaks: new insights into the mechanism of non-homologous end joining
> Biochemical Society Transactions
Published: 03 October 2023
Figure 4. Other dimeric forms of DNA-PKcs. ( A ) Structure of the apo DNA-PKcs dimer captured in the absence of other NHEJ factors [ 60 ]. The interaction site occludes Ku70/80 binding, implying that this state is an inactive form of the kinase. ( B ) Domain-swap dimer [ 64 ]. ( C ) Closeup of DN... More about this image found in Other dimeric forms of DNA-PKcs. ( A ) Structure of the apo DNA-PKcs dimer...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230042.
Published: 29 September 2023
Images
in Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions
> Biochemical Society Transactions
Published: 29 September 2023
Figure 1. Summary of the current knowledge on PIEZO1 mechanisms of activation and recruitment to focal adhesions, its role on focal adhesion and cytoskeletal dynamics as well as the downstream physiological and pathological implications. Abbreviations: α-SMA, alpha-smooth muscle actin; ERK1/2, ex... More about this image found in Summary of the current knowledge on PIEZO1 mechanisms of activation and rec...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20220898.
Published: 28 September 2023
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221455.
Published: 28 September 2023
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230265.
Published: 28 September 2023
Images
Published: 28 September 2023
Figure 1. Architectures of SMC complexes and Hi-C results of various species. ( A ) Drawings of SMC complexes architectures. ( B ) Drawings of architectures of SMC complexes of various species. More about this image found in Architectures of SMC complexes and Hi-C results of various species. ( A ) ...
Images
Published: 28 September 2023
Figure 2. In vitro single-molecule observation of DNA-loop extrusion using different methods. ( A ) Visualization of DNA-loop extrusion by single-molecule fluorescence assay with yeast condensin. Permissioned from ref. [ 31 ]. ( B ) AFM image of DNA-loop extrusion. Reproduced from ref. [ 23 ]. ... More about this image found in In vitro single-molecule observation of DNA-loop extrusion using different...
Images
Published: 28 September 2023
Figure 3. Potential DNA-interacting sites in the SMC complexes. ( A ) Cartoon depicting DNA-interacting sites of the SMC complex. Yellow overlays are positively charged DNA-binding sites. ( B ) Structure of the globular domain of SMC complex in the ATP-bound state gripping DNA. Dimerized SMC head... More about this image found in Potential DNA-interacting sites in the SMC complexes. ( A ) Cartoon depict...
Images
Published: 28 September 2023
Figure 4. Description of different DNA-loop extrusion working models. ( A ) Cartoon of conformational transition from the ATP-unbound hinge-released O shape to the ATP-bound hinge-engaged B shape. ( B ) Drawings of Scrunching model. ( C ) Cartoon of conformational change from gripping state (hing... More about this image found in Description of different DNA-loop extrusion working models. ( A ) Cartoon ...
Images
in The role of lipid scramblases in regulating lipid distributions at cellular membranes
> Biochemical Society Transactions
Published: 28 September 2023
Figure 1. Lipid asymmetry and lipid scramblases in regulating lipid distributions at cellular membranes. ( a ) Schematic illustration of lipid asymmetry of the plasma membrane (PM). Phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) are mainly distributed in the... More about this image found in Lipid asymmetry and lipid scramblases in regulating lipid distributions at ...
Images
in The role of lipid scramblases in regulating lipid distributions at cellular membranes
> Biochemical Society Transactions
Published: 28 September 2023
Figure 2. Representative scramblase candidates in cellular membranes. Scramblases are not only found in the PM, but also in intracellular membranes. Activity of scramblases are under strict regulation in the PM. TMEM16F is the scramblase activated by the elevated cytoplasmic Ca 2+ [ 14 ]. Upon a... More about this image found in Representative scramblase candidates in cellular membranes. Scramblases ar...
Images
in The role of lipid scramblases in regulating lipid distributions at cellular membranes
> Biochemical Society Transactions
Published: 28 September 2023
Figure 3. Models for lipid scrambling. ( a ) Credit card model for lipid scrambling. The hydrophilic head group of the phospholipid (magnetic strip on the credit card) diffuses through the hydrophilic groove of the scramblase (track of the card reader) during lipid scrambling. Illustration reprod... More about this image found in Models for lipid scrambling. ( a ) Credit card model for lipid scrambling....
Images
in The role of lipid scramblases in regulating lipid distributions at cellular membranes
> Biochemical Society Transactions
Published: 28 September 2023
Figure 4. Organization of scramblases in intracellular membranes. ( a ) Scramblase may interact with components of the (glyco)lipid biosynthetic pathway to facilitate efficient biosynthesis of (glycol)lipids in the membrane of an organelle — such as the ER. ( b ) Cooperation between scramblases a... More about this image found in Organization of scramblases in intracellular membranes. ( a ) Scramblase m...
Images
in ALTercations at telomeres: stress, recombination and extrachromosomal affairs
> Biochemical Society Transactions
Published: 28 September 2023
Figure 1. ALT-mediated telomere synthesis. ( a ) Increased and unresolved replication stress at telomeres of the ALT cells leads to fork stalling, which can be processed either by fork reversal factors (left) such as FANCM, WRN and FEN1 (indicated in yellow), resulting in restart of the fork or b... More about this image found in ALT-mediated telomere synthesis. ( a ) Increased and unresolved replicatio...
Images
in ALTercations at telomeres: stress, recombination and extrachromosomal affairs
> Biochemical Society Transactions
Published: 28 September 2023
Figure 2. Origin of ALT telomere maintenance. PML-dependent localization of the BTR complex to telomeres is required and sufficient to induce ALT phenotypes. Loss of ATRX or DAXX, may be contributing to APB establishment in several mechanisms: (i) persistent telomere replication stress, which, in... More about this image found in Origin of ALT telomere maintenance. PML-dependent localization of the BTR ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230120.
Published: 25 September 2023
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230617.
Published: 25 September 2023
Images
Published: 25 September 2023
Figure 1. High-resolution structures of amyloid folds adopted by α-synuclein, amyloid-β and glucagon. Two examples shown for each protein. Images are taken from the AmyloidAtlas at https://people.mbi.ucla.edu/sawaya/amyloidatlas/ that is described in [ 6 ]. Except for glucagon, there are many m... More about this image found in High-resolution structures of amyloid folds adopted by α-synuclein, amyloid...
Images
Published: 25 September 2023
Figure 2. Possible scope of new findings. Chemical reactivity of pathological amyloids may be an unexplored gain-of-function in amyloid-related diseases (such as in neurodegenerative disorders like Alzheimer's and Parkinson's). Amyloid-mediated chemical catalysis (illustrated by scissors; only ac... More about this image found in Possible scope of new findings. Chemical reactivity of pathological amyloi...
Images
in Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion
> Biochemical Society Transactions
Published: 25 September 2023
Figure 1. The catalytic structure of [FeFe] and [NiFe]-hydrogenases. (a) The architecture of the catalytic clusters of [NiFe] and [FeFe]-hydrogenases. Lig = H 2 or OH depending of the state of the catalytic cluster. ( b ) The CryoEM structure of the complex [NiFe]-hydrogenase Huc from M. smegma... More about this image found in The catalytic structure of [FeFe] and [NiFe]-hydrogenases. (a) The archite...
Images
in Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion
> Biochemical Society Transactions
Published: 25 September 2023
Figure 2. The application of [NiFe]-hydrogenases in fuel cell development. ( a ) A simplified schematic of the general design for a PEMFC. ( b ) A simplified schematic for the general design of a membrane-less [NiFe]-hydrogenase EBFC, similar to those described by Xu and Armstrong [ 14 ]. ( c ) C... More about this image found in The application of [NiFe]-hydrogenases in fuel cell development. ( a ) A s...
Images
in Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion
> Biochemical Society Transactions
Published: 25 September 2023
Figure 3. The structure of the [NiFe]-hydrogenase core catalytic complex. The structure of core large and small catalytic subunits of [NiFe]-hydrogenases (left), and the arrangement of catalytic [NiFe] and electron transferring [FeS] cofactors present in the [NiFe]-hydrogenases large and small su... More about this image found in The structure of the [NiFe]-hydrogenase core catalytic complex. The struct...
Images
in Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion
> Biochemical Society Transactions
Published: 25 September 2023
Figure 4. The complex structural of native [NiFe]-hydrogenases limits electron transfer to electrodes. ( a ) Structures of examples of [NiFe]-hydrogenases that form parts of larger multisubunit complexes. ( b ) A schematic showing the optimal orientation of a [NiFe]-hydrogenase, for electron tran... More about this image found in The complex structural of native [NiFe]-hydrogenases limits electron transf...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20220603.
Published: 22 September 2023
Images
in A tail of their own: regulation of cardiolipin and phosphatidylinositol fatty acyl profile by the acyltransferase LCLAT1
> Biochemical Society Transactions
Published: 22 September 2023
Figure 1. Abundant lipid acyl species and acyl remodeling of phosphatidylinositol and cardiolipin. Diagrams showing the predominant species of phosphatidylinositol (sn1-stearoyl, sn2-arachidonyl) ( A ) and cardiolipin (tetra-linoleoyl) ( B ). In both, color boxes highlight glycerol (yellow), arac... More about this image found in Abundant lipid acyl species and acyl remodeling of phosphatidylinositol and...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20210567.
Published: 18 September 2023
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20230081.
Published: 18 September 2023
Images
Published: 18 September 2023
Figure 1. Histones are frequently mutated in cancer and coincide with worse overall survival. ( A ) Location of histone genes on each chromosome. ( B ) Frequency of histone mutations by cancer type in studies with a minimum of 100 cases. ( C ) Comparison of overall survival for cancer patients wi... More about this image found in Histones are frequently mutated in cancer and coincide with worse overall s...
Images
Published: 18 September 2023
Figure 2. Survey of the most frequent core histone mutations in cancer patient samples. A cross cancer mutation summary was performed using the cBioPortal to search a total of 29 836 non-redundant patient samples across all cancer types, excluding sample not profiled for all histone genes. The nu... More about this image found in Survey of the most frequent core histone mutations in cancer patient sample...
Images
Published: 18 September 2023
Figure 3. Analysis of H2B E76 mutations in cancer. ( A ) Distribution of missense mutations at H2B amino acid E76. ( B ) Frequency of mutation at E76 across H2B genes. ( C ) H2B E76 variant allele frequency in all cancer types. ( D ) Distribution of cancer types with H2B E76 mutations. ( E ) The ... More about this image found in Analysis of H2B E76 mutations in cancer. ( A ) Distribution of missense mu...
Images
Published: 18 September 2023
Figure 4. Survey of histone H1 mutations in cancer. A cross cancer mutation summary was performed using cBioPortal to search 29 836 non-redundant patient samples across all cancer types for mutations in histone H1, excluding patient samples not profiled for all H1 genes. Alignment of H1 proteins ... More about this image found in Survey of histone H1 mutations in cancer. A cross cancer mutation summary ...
Images
Published: 18 September 2023
Figure 5. Histone mutations may alter chromatin structure and function by diverse mechanisms. ( A ) Histone mutations that affect sites of post-translational modification can block epigenetic writers such as PRC2, resulting in a redistribution of epigenetic marks that regulate gene expression. HM... More about this image found in Histone mutations may alter chromatin structure and function by diverse mec...
Images
Published: 18 September 2023
Figure 1. Structure of cytoglobin. ( A ) Stereoview of the heme pocket environment with notable structural and functional amino acids (PDB: 2DC3 ). The heme is shown edge-on with the heme pocket entrance to the front. ( B ) Monomeric protein, without intramolecular disulfide bond (PDB: 1VH5 ). ... More about this image found in Structure of cytoglobin. ( A ) Stereoview of the heme pocket environment w...
Images
Published: 18 September 2023
Figure 2. Possible cytoglobin biochemistry and cellular pathways. Cygb is up-regulated by HIF-1 under conditions of hypoxia. Ferrous Cygb H (hexacoordinate) can react with nitrite under hypoxic conditions to generate NO. Under normoxic conditions, the protein binds oxygen and can react with NO t... More about this image found in Possible cytoglobin biochemistry and cellular pathways. Cygb is up-regulat...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221542.
Published: 01 September 2023
Images
in Applications of artificial intelligence and machine learning in dynamic pathway engineering
> Biochemical Society Transactions
Published: 01 September 2023
Figure 1. Applications areas of machine learning in dynamic pathway engineering: retrosynthesis, biosensor design, and circuit architecture design. ( A ) Exemplar dynamic pathway whereby metabolites bind to transcriptional biosensors that control the temporal enzyme expression. ( B ) Pathway asse... More about this image found in Applications areas of machine learning in dynamic pathway engineering: retr...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) BST20221363.
Published: 31 August 2023
... ]. Rat ( Rattus norvegicus ) — Neuroprotective function in PD model (induced by the neurotoxin 6-OHDA) [ 53 ]. Nematode ( C. elegans ) — cbp-1 (CBP/p300 homolog) is essential for baicalein activity [ 51 ]. Rat ( Rattus norvegicus ) — miR-30b-5p and the SIRT1/AMPK/mTOR pathway [ 53 ]. Carnosic acid...
Images
in Mitophagy-promoting agents and their ability to promote healthy-aging
> Biochemical Society Transactions
Published: 31 August 2023
Figure 1. Schematic illustration of three mitophagy pathways (left to right, inspired by [ 23 ]). PINK1/Parkin-dependent mitophagy: The decrease in membrane potential in damaged mitochondrial regions leads to the accumulation of PINK1 on the outer mitochondrial membrane (OMM), where it recruits P... More about this image found in Schematic illustration of three mitophagy pathways (left to right, inspired...
Images
in Mitophagy-promoting agents and their ability to promote healthy-aging
> Biochemical Society Transactions
Published: 31 August 2023
Figure 2. Healthy mitophagy activation by natural and synthetic substances. A variety of natural and synthetic substances induces mitophagy. Selectively removing damaged mitochondria ensures cellular health and presents an emerging therapeutic strategy to promote healthy aging. More about this image found in Healthy mitophagy activation by natural and synthetic substances. A variet...
Images
in Mitophagy-promoting agents and their ability to promote healthy-aging
> Biochemical Society Transactions
Published: 31 August 2023
Figure 3. The biphasic effect of mitophagy. The basal level of mitophagy in wild-type worms is significantly lower than in daf-2 mutants. Similarly, their resistance to oxidative stress is also lower, as represented by the dark circle and hexagon, respectively. Treatment with VL-004 increases t... More about this image found in The biphasic effect of mitophagy. The basal level of mitophagy in wild-typ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (4): 1661–1673.
Published: 29 August 2023
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