.... In this review, we discuss the links between translation and mRNA stability, with an emphasis on emerging data suggesting that codon optimality may regulate mRNA degradation. The genetic code is degenerate, with 61 nucleotide triplet codons encoding 20 different amino acids [ 78 ]. As a result, all amino acids...

...: 10.1126/science.1250897 49 Moon , S.L. , Anderson , J.R. , Kumagai , Y. , Wilusz , C.J. , Akira , S. , Khromykh , A.A. et al. ( 2012 ) A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability...

... the early phase of the response to a pro-inflammatory agonist, such as LPS, strong MAPK p38 activity promotes the expression of TTP at the levels of transcription, mRNA stability, mRNA translation and protein stability. Although direct experimental evidence is lacking, the TTP that accumulates under...

...Christopher Tiedje; Alexey Kotlyarov; Matthias Gaestel TTP (tristetraprolin) is an RNA-binding protein which regulates mRNA stability or translation or both. The molecular mechanisms which are responsible and which discriminate between regulation of mRNA stability and translation are not completely...

... uncharacterized mechanisms of zinc-regulated transcription in mammalian cells. In addition, recent findings reveal a role for effects of zinc on mRNA stability in the regulation of specific zinc transporters. Our studies on the regulation of the human gene SLC30A5 (solute carrier 30A5), which codes for the zinc...

... is induced rapidly and transiently in response to a plethora of stimuli; (ii) COX - 2 mRNA stability and translational efficiency is governed by multiple regulatory elements within the 3′-untranslated region; (iii) specific microRNAs and RNA-binding proteins influence COX - 2 mRNA stability; and (iv...

... Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase (PNPase) Human mtDNA (hmtDNA) is a small (16569 nt) double-stranded circular molecule containing no introns, with the main regulatory elements involved in replication and transcription...

... regulation methionine biosynthesis mRNA stability nascent polypeptide S -adenosylmethionine 1 Present address: Center for Plant Molecular Genetics and Breeding Research, Seoul National University, Seoul 151-742, South Korea. 2 Present address: Delaware Biotechnology Institute...