... cell proliferation mRNA degradation yeast In eukaryotes, cytoplasmic mRNA decay is initiated by removal of the poly(A) tail. This first step in the turnover pathway is unique in that it is reversible and some transcripts can be readenylated and returned to polysomes. CCR4 (CC chemokine...

... 2010 Biochemical Society 2010 endonuclease mRNA degradation nonsense-mediated mRNA decay premature translation-termination codon (PTC) The cascade of events during gene expression involves a series of complex and tightly linked steps from transcription of the DNA-encoded genetic...

... on the function, assembly and motility of P-bodies. An updated list of proteins and RNAs that localize to P-bodies will help in keeping track of this fast-growing field. P-bodies are small cytoplasmic foci that contain most enzymes required for mRNA degradation ( Figure 1 ). These foci were discovered more than...

... that cells undergo in response to iron deficit and the regulatory mechanisms that allow these adaptive responses. In the present article, we summarize recent work on genome-wide metabolic reprogramming in response to iron deficiency, mediated by specific mRNA degradation mechanisms that allow S. cerevisiae...

..., summarize TTP-interacting proteins and discuss how phosphorylation regulates the activity, localization and stability of TTP. AU-rich element cytokine mRNA degradation processing body stress granule tristetraprolin The role of TTP was uncovered by the careful analysis of TTP-knockout mice...

... the exosome and a 5′–3′-exoribonuclease are important in the degradation of very unstable transcripts, whereas the CAF1/NOT complex plays a major role in the degradation of all mRNAs tested. Targeted RNA interference screening was used to identify RNA-binding proteins that regulate mRNA degradation...

.... This article reviews the pathways and enzymes that control mRNA turnover in eukaryotic cells and discusses their mechanisms of control. 1 email s.f.newbury@ncl.ac.uk 23 6 2005 © 2006 The Biochemical Society 2006 gene expression mRNA turnover mRNA degradation post-transcriptional...