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Keywords: mRNA decay
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Articles
Biochem Soc Trans (2020) 48 (3): 1199–1211.
Published: 15 May 2020
... sequencing-based studies have further established that mutations in genes encoding proteins involved in RNA metabolism are a major cause of NDD. Here, we review recent studies linking germline mutations in genes encoding factors mediating mRNA decay and regulators of translation, namely DCPS, EDC3, DDX6...
Articles
Biochem Soc Trans (2014) 42 (4): 1238–1245.
Published: 11 August 2014
... on the metazoan 4E-T (4E-transporter)/Cup family of eIF4E-binding proteins, and also discuss very recent examples in yeast, fruitflies and humans, some of which predictably inhibit translation, while others may result in mRNA decay or even enhance translation; altogether considerably expanding our understanding...
Articles
Biochem Soc Trans (2014) 42 (1): 184–187.
Published: 23 January 2014
... To whom correspondence should be addressed (email passmore@mrc-lmb.cam.ac.uk ). 4 9 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 exonuclease gene expression mRNA mRNA decay poly(A) tail Pan3 is the 76-kDa interacting partner of Pan2 [ 12 ] ( Figure...
Articles
Biochem Soc Trans (2012) 40 (4): 856–864.
Published: 20 July 2012
... in mRNA decay, as well as roles in the regulation of mRNA turnover by cis -acting control elements and in the detection of aberrant mRNA transcripts. In the present paper, we review our current understanding of the complex roles of PABP1 in mRNA turnover, focusing on recent progress in mammals...
Articles
Biochem Soc Trans (2012) 40 (4): 896–901.
Published: 20 July 2012
... Biochemical Society 2012 BTG/Tob Ccr4–Not complex deadenylase mRNA processing mRNA decay ribonuclease Mature eukaryotic mRNA contains, with only few exceptions such as the histone mRNAs, an m 7 G (7-methylguanylate) cap structure at the 5′-end and a 3′-polyadenylate/poly(A) tail. The cap...
Articles
Biochem Soc Trans (2010) 38 (6): 1506–1510.
Published: 24 November 2010
... decay) pathway (discussed below) and is thought to promote mRNA decay when it is recruited during translation termination. The degradation of histone mRNA involves oligouridylation at the 3′-end, a modification believed to stimulate decapping and exonucleolytic decay of the mRNA [ 23 ]. cis...
Articles
Biochem Soc Trans (2008) 36 (4): 698–700.
Published: 22 July 2008
...Saverio Brogna; Preethi Ramanathan; Jikai Wen NMD (nonsense-mediated mRNA decay) is a mechanism that degrades transcripts containing PTCs (premature translation termination codons). NMD is a translation-associated process that is expected to take place throughout the cytoplasm. However, recent...
Articles
Biochem Soc Trans (2006) 34 (1): 39–42.
Published: 20 January 2006
...N. Amrani; S. Dong; F. He; R. Ganesan; S. Ghosh; S. Kervestin; C. Li; D.A. Mangus; P. Spatrick; A. Jacobson NMD (nonsense-mediated mRNA decay) is a cellular quality-control mechanism in which an otherwise stable mRNA is destabilized by the presence of a premature termination codon. We have defined...
Articles
Biochem Soc Trans (2006) 34 (1): 35–38.
Published: 20 January 2006
... GMP (N7-methyl GMP). In this review, we will highlight the function of different decapping enzymes and their role in mRNA turnover. 25 7 2005 © 2006 The Biochemical Society 2006 decapping enzyme histidine triad motif (HIT motif) mRNA decay Nudix motif Regulation of mRNA...