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Biochem Soc Trans (2023) 51 (5): 1777–1787.
Published: 16 October 2023
...Frances M. Platt Lysosomal storage diseases are inborn errors of metabolism that arise due to loss of function mutations in genes encoding lysosomal enzymes, protein co-factors or lysosomal membrane proteins. As a consequence of the genetic defect, lysosomal function is impaired and substrates...
Biochem Soc Trans (2022) 50 (4): 1143–1155.
Published: 12 August 2022
...Anthony J. Morgan; Lora L. Martucci; Lianne C. Davis; Antony Galione In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P 2 , TPCs are an integral part...
Biochem Soc Trans (2022) 50 (1): 621–632.
Published: 28 February 2022
... and represent key events in the development and progression of the pathology. The present minireview covers recent articles (2018–2021) investigating the role of LRRK2 and LRRK2 mutants in the regulation of synaptic activity and autophagy-lysosomal pathway. These articles confirm a perturbation of synaptic...
In CollectionCell death and survival
Biochem Soc Trans (2022) 50 (1): 47–54.
Published: 15 February 2022
...Shuhei Nakamura; Shiori Akayama; Tamotsu Yoshimori Autophagy is an evolutionally conserved cytoplasmic degradation pathway in which the double membrane structure, autophagosome sequesters cytoplasmic material and delivers them to lysosomes for degradation. Many autophagy related (ATG) proteins...
In CollectionCell death and survival
Biochem Soc Trans (2022) 50 (1): 55–69.
Published: 25 January 2022
.... The hallmark of autophagy is the de novo formation of autophagosomes, which are double-membrane vesicles that sequester and deliver cytoplasmic materials to lysosomes/vacuoles for degradation. The mechanism of autophagosome biogenesis entered a molecular era with the identification of autophagy-related (ATG...
Biochem Soc Trans (2021) 49 (5): 2063–2072.
Published: 08 September 2021
... trafficking, autophagy, and lysosome biology. LRRK2 binds and phosphorylates key regulators of the endomembrane systems and is dynamically localized at the Golgi. The impact of LRRK2 on the Golgi may reverberate throughout the entire endomembrane system and occur in multiple intersecting pathways, including...
Biochem Soc Trans (2020) 48 (2): 709–717.
Published: 04 March 2020
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . lesion lysosomes mitochondrial damage selectivity striatum toxin In the brain, particularly with regard...
Biochem Soc Trans (2019) 47 (4): 1173–1185.
Published: 05 August 2019
...Michael Ebner; Philipp Alexander Koch; Volker Haucke Lysosomes are the main degradative compartments of mammalian cells and serve as platforms for cellular nutrient signaling and sterol transport. The diverse functions of lysosomes and their adaptation to extracellular and intracellular cues...
Biochem Soc Trans (2018) 46 (1): 97–110.
Published: 05 January 2018
...Kevin C. Yang; Paalini Sathiyaseelan; Cally Ho; Sharon M. Gorski Autophagy is an evolutionarily conserved lysosome-mediated degradation and recycling process, which functions in cellular homeostasis and stress adaptation. The process is highly dynamic and involves autophagosome synthesis, cargo...
Biochem Soc Trans (2016) 44 (3): 891–897.
Published: 09 June 2016
...Carine de Marcos Lousa; Jurgen Denecke Soluble hydrolases represent the main proteins of lysosomes and vacuoles and are essential to sustain the lytic properties of these organelles typical for the eukaryotic organisms. The sorting of these proteins from ER residents and secreted proteins...
Biochem Soc Trans (2015) 43 (3): 434–441.
Published: 01 June 2015
...Jonathan S. Marchant; Sandip Patel Two-pore channels (TPCs) are ancient members of the voltage-gated ion channel superfamily that localize to acidic organelles such as lysosomes. The TPC complex is the proposed target of the Ca 2+ -mobilizing messenger NAADP, which releases Ca 2+ from these acidic...