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Keywords: lysosome
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Articles
Biochem Soc Trans (2023) 51 (2): 587–595.
Published: 17 March 2023
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ciliogenesis LRRK2 lysosome Parkinson's disease phosphorylation/dephosphorylation Rab protein Parkinson's...
Articles
Biochem Soc Trans (2022) 50 (6): 1773–1783.
Published: 09 December 2022
..., but rather mitochondria are engulfed directly by lysosomes, mediating mitochondrial secretion. As FNZ results in parkinsonism, we propose that excessive mitolysosome exocytosis is the cause. It is important to explore the role of mitolysosome exocytosis in PD pathology and even more broadly...
Articles
Biochem Soc Trans (2018) 46 (2): 207–215.
Published: 22 February 2018
...Ana Serrano-Puebla; Patricia Boya Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the intracellular degradation of macromolecules. Damage of these organelles often results in lysosomal membrane permeabilization (LMP) and the release into the cytoplasm of the soluble...
Articles
Biochem Soc Trans (2016) 44 (2): 546–553.
Published: 11 April 2016
... ) and IP 3 receptor (IP 3 R) on the endoplasmic reticulum (ER). A less understood, parallel Ca 2+ signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca 2+ release from acidic Ca 2+ stores [e.g. endo-lysosomes, secretory vesicles...
Articles
Biochem Soc Trans (2016) 44 (1): 177–184.
Published: 09 February 2016
... 4 lysosome neurodegeneration PIKfyve Vac14 Fab1–PIKfyve is the sole lipid kinase that synthesizes PI(3,5)P 2 from phosphatidylinositol-3-phosphate (PI(3) P ) [ 6 , 9 , 10 ]. Fab1 was identified in the budding yeast S. cerevisiae [ 11 ] and was shown to function as a vacuolar PI(3) P...
Articles
Biochem Soc Trans (2015) 43 (3): 384–389.
Published: 01 June 2015
... Anthony.morgan@pharm.ox.ac.uk ) . 12 11 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 NAADP TPC Ca 2+ lysosome endosome Ca 2+ mobilization from intracellular stores is an ancient and conserved signal transduction pathway from plants to animals, and while...
Articles
Biochem Soc Trans (2014) 42 (5): 1460–1464.
Published: 18 September 2014
...Ana M. Villamil Giraldo; Hanna Appelqvist; Thomas Ederth; Karin Öllinger Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes...
Articles
Biochem Soc Trans (2014) 42 (1): 63–70.
Published: 23 January 2014
... also allows them to direct Ca 2+ to specific intracellular targets that include other IP 3 Rs, mitochondria and Ca 2+ -regulated channels and enzymes. IP 3 Rs also interact functionally with lysosomes because Ca 2+ released by IP 3 Rs, but not that entering cells via store-operated Ca 2+ entry pathways...
Articles
Biochem Soc Trans (2013) 41 (6): 1495–1502.
Published: 20 November 2013
... disrupts lysosomal function and Ca 2+ homoeostasis, both of which are considered strong pathogenic factors in FAD. Loss of PS1 function compromises assembly and proton-pumping activity of the vacuolar-ATPase on lysosomes, leading to defective lysosomal acidification and marked impairment of autophagy...
Articles
Biochem Soc Trans (2013) 41 (6): 1509–1512.
Published: 20 November 2013
...Ryan P. McGlinchey; Jennifer C. Lee Mutations in the GBA1 gene, encoding the enzyme glucocerebrosidase, cause the lysosomal storage disorder GD (Gaucher’s disease), and are associated with the development of PD (Parkinson's disease) and other Lewy body disorders. Interestingly, GBA1 variants...
Articles
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
... proteins in lysosomes. Tight connections between CMA and neurodegeneration originated from the realization that many of the proteins related to the pathogenesis of common neurodegenerative disorders contain a CMA-targeting motif in their amino acid sequence ( Figure 1 ). α-Synuclein, a main component...
Articles
Biochem Soc Trans (2013) 41 (4): 951–955.
Published: 18 July 2013
... and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity. The heterodimeric Rag GTPases localize mTORC1 to lysosomes by their amino-acid-dependent interaction with the lysosomal Ragulator complex. Rheb is also thought to reside on lysosomes to activate mTORC1...
Articles
Biochem Soc Trans (2013) 41 (2): 475–490.
Published: 21 March 2013
..., antigens derived from the degraded microbe are then secondarily presented on the surface of the phagocyte. To achieve this degradation, phagosomes undergo a series of maturation stages, receiving new material from early endosomes, late endosomes and finally lysosomes and also losing molecules no longer...
Articles
Biochem Soc Trans (2012) 40 (5): 1147–1151.
Published: 19 September 2012
... of view, the hypothesis that LRRK2 could have a role in the autophagy–lysosome pathway is intriguing. From the pathological side, the involvement of LRRK2 in autophagy is consistent with the degeneration described in LRRK2-PD brains; the fact that other PD-related genes, such as GBA (glucosidase β...
Articles
Biochem Soc Trans (2012) 40 (1): 153–157.
Published: 19 January 2012
...Sandip Patel; Eugen Brailoiu NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent Ca 2+ -mobilizing messenger implicated in many Ca 2+ -dependent cellular processes. It is highly unusual in that it appears to trigger Ca 2+ release from acidic organelles such as lysosomes. These signals...
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Articles
Biochem Soc Trans (2010) 38 (6): 1417–1419.
Published: 24 November 2010
...Paul R. Pryor; Sally A. Raines Lysosomes form part of our innate immunity and are an important line of defence against microbes, viruses and parasites. Although it is more than 50 years since de Duve discovered lysosomes, it is only in more recent years that we are slowly unravelling the molecular...
Articles
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
...Paul Saftig; Bernd Schröder; Judith Blanz Whereas we have a profound understanding about the function and biogenesis of the protein constituents in the lumen of the lysosomal compartment, much less is known about the functions of proteins of the lysosomal membrane. Proteomic analyses...
Articles
Biochem Soc Trans (2010) 38 (6): 1424–1431.
Published: 24 November 2010
... the endoplasmic reticulum, the major site of action of the other two principal Ca 2+ -mobilizing messengers, Ins P 3 and cADPR (cADP-ribose). Studies of the messenger roles of NAADP and the function of TPCs highlight the novel role of lysosomes and other organelles of the endocytic pathway as messenger-regulated...
Articles
Biochem Soc Trans (2010) 38 (6): 1479–1483.
Published: 24 November 2010
...Nikolaj H.T. Petersen; Thomas Kirkegaard Lysosomes, with their arsenal of catabolic enzymes and crucial metabolic housekeeping functions are experiencing a revived research interest after having lived a rather quiet life for the last few decades. With the discovery of the interaction...
Articles
Biochem Soc Trans (2010) 38 (6): 1413–1416.
Published: 24 November 2010
...J. Paul Luzio; Sally R. Gray; Nicholas A. Bright The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us...
Articles
Biochem Soc Trans (2010) 38 (6): 1469–1473.
Published: 24 November 2010
... with lysosomes, leading to degradation of the internalized proteins. Four ESCRT complexes interact to concentrate cargo on the endosomal membrane, induce membrane curvature to form an intraluminal bud and finally pinch off the bud through a membrane-scission event to produce the intraluminal vesicle. Recent work...
Articles
Biochem Soc Trans (2009) 37 (5): 1019–1021.
Published: 21 September 2009
...J. Paul Luzio; Michael D.J. Parkinson; Sally R. Gray; Nicholas A. Bright In mammalian cells, endocytosed cargo that is internalized through clathrin-coated pits/vesicles passes through early endosomes and then to late endosomes, before delivery to lysosomes for degradation by proteases. Late...
Articles
Biochem Soc Trans (2009) 37 (1): 178–180.
Published: 20 January 2009
... vesicles of MVBs (multivesicular bodies). We have focussed on studying the ESCRT requirements for delivery of MHC class I to lysosomes following polyubiquitination by the Kaposi's sarcoma-associated herpesvirus protein K3. Down-regulation of polyubiquitinated cell-surface MHC class I in HeLa cells stably...
Articles
Biochem Soc Trans (2009) 37 (1): 151–155.
Published: 20 January 2009
..., cytoskeletal remodelling, protein folding and proteolysis. The AAA Vps (vacuolar protein sorting) 4 is central to traffic to lysosomes, retroviral budding and mammalian cell division. It dissociates ESCRTs (endosomal sorting complexes required for transport) from endosomal membranes, enabling their recycling...
Articles
Biochem Soc Trans (2007) 35 (5): 1088–1091.
Published: 25 October 2007
...J.P. Luzio; N.A. Bright; P.R. Pryor The passage of endocytosed receptor-bound ligands and membrane proteins through the endocytic pathway of mammalian cells to lysosomes occurs via early and late endosomes. The latter contain many luminal vesicles and are often referred to as MVBs (multivesicular...
Articles
Biochem Soc Trans (2007) 35 (2): 343–348.
Published: 20 March 2007
... and resemble thermosensitizers [ 16 ]. These results suggest that the combination of hyperthermia and spermine enzymatic oxidation products could prove to be useful in cancer treatment and mainly effective against MDR cells. hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell...
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Biochem Soc Trans (2006) 34 (5): 922–926.
Published: 25 October 2006
... model for NAADP-induced Ca 2+ signalling is presented. 1 email antony.galione@pharm.ox.ac.uk 3 8 2006 © 2006 The Biochemical Society 2006 bafilomycin Ca 2+ store endoplasmic reticulum inositol 1,4,5-trisphosphate (IP 3 ) lysosome nicotinic acid–adenine dinucleotide...
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Biochem Soc Trans (2006) 34 (3): 340–342.
Published: 22 May 2006
... vacuole, like the mammalian lysosome, is an acidic organelle that functions in a variety of macromolecule recycling and storage capacities, including autophagy. Autophagy, or ‘self-eating’, is classically viewed as a starvation response, but it is employed in numerous other contexts where bulk degradation...
Articles
Biochem Soc Trans (2001) 29 (4): 488–493.
Published: 01 August 2001
... that a GHR truncated at residue 369 can enter the cells in the presence of a proteasome inhibitor, but that the subsequent lysosomal degradation of GH is blocked. Lysosomal inhibitors prolong the half-life of both receptor and ligand. Experiments with antibodies against different receptor tail sections show...