Search Results | Biochemical Society Transactions

1-30 of 30

Sort by

Sort Order Select

Articles

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation

Rachel Fasiczka, Yahaira Naaldijk, Besma Brahmia, Sabine Hilfiker

Biochem Soc Trans (2023) 51 (2): 587–595.

DOI: https://doi.org/10.1042/BST20201145

Published: 17 March 2023

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . ciliogenesis LRRK2 lysosome Parkinson's disease phosphorylation/dephosphorylation Rab protein Parkinson's disease (PD) is a progressive, debilitating neurodegenerative...

View article titled, Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation

Articles

Mitolysosome exocytosis: a novel mitochondrial quality control pathway linked with parkinsonism-like symptoms

Feixiang Bao, Lingyan Zhou, Jiahui Xiao, Xingguo Liu

Biochem Soc Trans (2022) 50 (6): 1773–1783.

DOI: https://doi.org/10.1042/BST20220726

Published: 09 December 2022

..., but rather mitochondria are engulfed directly by lysosomes, mediating mitochondrial secretion. As FNZ results in parkinsonism, we propose that excessive mitolysosome exocytosis is the cause. Correspondence: Xingguo Liu ( liu_xingguo@gibh.ac.cn ) 27 9 2022 14 11 2022 25 11 2022 ©...

View article titled, Mitolysosome exocytosis: a novel mitochondrial quality control pathway linked with parkinsonism-like symptoms

Articles

Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

Ana Serrano-Puebla, Patricia Boya

Biochem Soc Trans (2018) 46 (2): 207–215.

DOI: https://doi.org/10.1042/BST20170130

Published: 22 February 2018

...Ana Serrano-Puebla; Patricia Boya Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the intracellular degradation of macromolecules. Damage of these organelles often results in lysosomal membrane permeabilization (LMP) and the release into the cytoplasm of the soluble...

View article titled, Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

Articles

Ca 2+ dialogue between acidic vesicles and ER

Anthony J. Morgan

Biochem Soc Trans (2016) 44 (2): 546–553.

DOI: https://doi.org/10.1042/BST20150290

Published: 11 April 2016

... ) and IP 3 receptor (IP 3 R) on the endoplasmic reticulum (ER). A less understood, parallel Ca 2+ signalling cascade is that involving the messenger nicotinic acid adenine dinucleotide phosphate (NAADP) that couples to Ca 2+ release from acidic Ca 2+ stores [e.g. endo-lysosomes, secretory vesicles...

View article titled, Ca 2+ dialogue between acidic vesicles and ER

Articles

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

Natsuko Jin, Michael J. Lang, Lois S. Weisman

Biochem Soc Trans (2016) 44 (1): 177–184.

DOI: https://doi.org/10.1042/BST20150174

Published: 09 February 2016

... lysosome neurodegeneration PIKfyve Vac14 Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. They regulate multiple pathways, including organization of the cytoskeleton, cellular motility, endocytosis and provide spatial and temporal...

View article titled, Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

Articles

TPC: the NAADP discovery channel?

Anthony J. Morgan, Lianne C. Davis, Margarida Ruas, Antony Galione

Biochem Soc Trans (2015) 43 (3): 384–389.

DOI: https://doi.org/10.1042/BST20140300

Published: 01 June 2015

.... 1 To whom correspondence should be addressed (email Anthony.morgan@pharm.ox.ac.uk ) . 12 11 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 NAADP TPC Ca 2+ lysosome endosome Ca 2+ mobilization from intracellular stores is an ancient...

View article titled, TPC: the NAADP discovery channel?

Articles

Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death

Ana M. Villamil Giraldo, Hanna Appelqvist, Thomas Ederth, Karin Öllinger

Biochem Soc Trans (2014) 42 (5): 1460–1464.

DOI: https://doi.org/10.1042/BST20140145

Published: 18 September 2014

...Ana M. Villamil Giraldo; Hanna Appelqvist; Thomas Ederth; Karin Öllinger Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization of the lysosomal membrane and release of hydrolytic enzymes...

View article titled, Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death

Articles

Structural organization of signalling to and from IP 3 receptors

Colin W. Taylor, Stephen C. Tovey, Ana M. Rossi, Cristina I. Lopez Sanjurjo, David L. Prole, Taufiq Rahman

Biochem Soc Trans (2014) 42 (1): 63–70.

DOI: https://doi.org/10.1042/BST20130205

Published: 23 January 2014

... also allows them to direct Ca 2+ to specific intracellular targets that include other IP 3 Rs, mitochondria and Ca 2+ -regulated channels and enzymes. IP 3 Rs also interact functionally with lysosomes because Ca 2+ released by IP 3 Rs, but not that entering cells via store-operated Ca 2+ entry pathways...

View article titled, Structural organization of signalling to and from IP 3 receptors

Articles

Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease

Ryan P. McGlinchey, Jennifer C. Lee

Biochem Soc Trans (2013) 41 (6): 1509–1512.

DOI: https://doi.org/10.1042/BST20130158

Published: 20 November 2013

...Ryan P. McGlinchey; Jennifer C. Lee Mutations in the GBA1 gene, encoding the enzyme glucocerebrosidase, cause the lysosomal storage disorder GD (Gaucher’s disease), and are associated with the development of PD (Parkinson's disease) and other Lewy body disorders. Interestingly, GBA1 variants...

View article titled, Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease

Articles

Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Jaime L. Schneider, Ana Maria Cuervo

Biochem Soc Trans (2013) 41 (6): 1483–1488.

DOI: https://doi.org/10.1042/BST20130126

Published: 20 November 2013

... proteins in lysosomes. 1 To whom correspondence should be addressed (email ana-maria.cuervo@einstein.yu.edu ). 2 7 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 aging autophagy chaperone lysosome neurodegeneration proteotoxicity Intracellular...

View article titled, Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Articles

Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

MaryKate McBrayer, Ralph A. Nixon

Biochem Soc Trans (2013) 41 (6): 1495–1502.

DOI: https://doi.org/10.1042/BST20130201

Published: 20 November 2013

... disrupts lysosomal function and Ca 2+ homoeostasis, both of which are considered strong pathogenic factors in FAD. Loss of PS1 function compromises assembly and proton-pumping activity of the vacuolar-ATPase on lysosomes, leading to defective lysosomal acidification and marked impairment of autophagy...

View article titled, Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

Articles

Rheb and Rags come together at the lysosome to activate mTORC1

Marlous J. Groenewoud, Fried J.T. Zwartkruis

Biochem Soc Trans (2013) 41 (4): 951–955.

DOI: https://doi.org/10.1042/BST20130037

Published: 18 July 2013

... and the Rags play a central role. The presence of amino acids is a strict requirement for mTORC1 activity. The heterodimeric Rag GTPases localize mTORC1 to lysosomes by their amino-acid-dependent interaction with the lysosomal Ragulator complex. Rheb is also thought to reside on lysosomes to activate mTORC1...

View article titled, Rheb and Rags come together at the lysosome to activate mTORC1

Articles

Mechanisms of microbial escape from phagocyte killing

Leanne M. Smith, Robin C. May

Biochem Soc Trans (2013) 41 (2): 475–490.

DOI: https://doi.org/10.1042/BST20130014

Published: 21 March 2013

... (email r.c.may@bham.ac.uk ). 4 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 intracellular survival lysosome macrophage pathogen phagocytosis phagosome Phagocytosis is arguably one of the most important processes in biology. From single-celled...

View article titled, Mechanisms of microbial escape from phagocyte killing

Articles

LRRK2 and autophagy: a common pathway for disease

Claudia Manzoni

Biochem Soc Trans (2012) 40 (5): 1147–1151.

DOI: https://doi.org/10.1042/BST20120126

Published: 19 September 2012

... leucine-rich repeat kinase 2 (LRRK2) lysosome membrane Parkinson's disease LRRK2 is a ubiquitously expressed [ 1 ] member of the ROCO protein family [ 2 ]. It is composed of an active serine/threonine kinase domain with sequence similarities to the RIPKs (receptor-interacting protein kinases...

View article titled, LRRK2 and autophagy: a common pathway for disease

Articles

Triggering of Ca 2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?

Sandip Patel, Eugen Brailoiu

Biochem Soc Trans (2012) 40 (1): 153–157.

DOI: https://doi.org/10.1042/BST20110693

Published: 19 January 2012

...Sandip Patel; Eugen Brailoiu NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent Ca 2+ -mobilizing messenger implicated in many Ca 2+ -dependent cellular processes. It is highly unusual in that it appears to trigger Ca 2+ release from acidic organelles such as lysosomes. These signals...

View article titled, Triggering of Ca 2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?

Articles

Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Maria João Sousa, Flávìa Azevedo, Ana Pedras, Carolina Marques, Olga P. Coutinho, Ana Preto, Hernâni Gerós, Susana R. Chaves, Manuela Côrte-Real

Biochem Soc Trans (2011) 39 (5): 1533–1537.

DOI: https://doi.org/10.1042/BST0391533

Published: 21 September 2011

... similarities to the mammalian intrinsic pathway was conserved in yeast. Recently, lysosomes have also emerged as central players in mammalian apoptosis. Following LMP (lysosomal membrane permeabilization), lysosomal proteases such as cathepsins B, D and L are released into the cytosol and can trigger...

View article titled, Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Articles

Manipulation of the host by pathogens to survive the lysosome

Paul R. Pryor, Sally A. Raines

Biochem Soc Trans (2010) 38 (6): 1417–1419.

DOI: https://doi.org/10.1042/BST0381417

Published: 24 November 2010

...Paul R. Pryor; Sally A. Raines Lysosomes form part of our innate immunity and are an important line of defence against microbes, viruses and parasites. Although it is more than 50 years since de Duve discovered lysosomes, it is only in more recent years that we are slowly unravelling the molecular...

View article titled, Manipulation of the host by pathogens to survive the lysosome

Articles

HSP70 and lysosomal storage disorders: novel therapeutic opportunities

Nikolaj H.T. Petersen, Thomas Kirkegaard

Biochem Soc Trans (2010) 38 (6): 1479–1483.

DOI: https://doi.org/10.1042/BST0381479

Published: 24 November 2010

...Nikolaj H.T. Petersen; Thomas Kirkegaard Lysosomes, with their arsenal of catabolic enzymes and crucial metabolic housekeeping functions are experiencing a revived research interest after having lived a rather quiet life for the last few decades. With the discovery of the interaction...

View article titled, HSP70 and lysosomal storage disorders: novel therapeutic opportunities

Articles

Endosome–lysosome fusion

J. Paul Luzio, Sally R. Gray, Nicholas A. Bright

Biochem Soc Trans (2010) 38 (6): 1413–1416.

DOI: https://doi.org/10.1042/BST0381413

Published: 24 November 2010

...J. Paul Luzio; Sally R. Gray; Nicholas A. Bright The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us...

View article titled, Endosome–lysosome fusion

Articles

Lysosomal membrane proteins: life between acid and neutral conditions

Paul Saftig, Bernd Schröder, Judith Blanz

Biochem Soc Trans (2010) 38 (6): 1420–1423.

DOI: https://doi.org/10.1042/BST0381420

Published: 24 November 2010

...Paul Saftig; Bernd Schröder; Judith Blanz Whereas we have a profound understanding about the function and biogenesis of the protein constituents in the lumen of the lysosomal compartment, much less is known about the functions of proteins of the lysosomal membrane. Proteomic analyses...

View article titled, Lysosomal membrane proteins: life between acid and neutral conditions

Articles

NAADP as an intracellular messenger regulating lysosomal calcium-release channels

Antony Galione, Anthony J. Morgan, Abdelilah Arredouani, Lianne C. Davis, Katja Rietdorf, Margarida Ruas, John Parrington

Biochem Soc Trans (2010) 38 (6): 1424–1431.

DOI: https://doi.org/10.1042/BST0381424

Published: 24 November 2010

... the endoplasmic reticulum, the major site of action of the other two principal Ca 2+ -mobilizing messengers, Ins P 3 and cADPR (cADP-ribose). Studies of the messenger roles of NAADP and the function of TPCs highlight the novel role of lysosomes and other organelles of the endocytic pathway as messenger-regulated...

View article titled, NAADP as an intracellular messenger regulating lysosomal calcium-release channels

Articles

The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes

Daniel Metcalf, Adrian M. Isaacs

Biochem Soc Trans (2010) 38 (6): 1469–1473.

DOI: https://doi.org/10.1042/BST0381469

Published: 24 November 2010

... with lysosomes, leading to degradation of the internalized proteins. Four ESCRT complexes interact to concentrate cargo on the endosomal membrane, induce membrane curvature to form an intraluminal bud and finally pinch off the bud through a membrane-scission event to produce the intraluminal vesicle. Recent work...

View article titled, The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes

Articles

The delivery of endocytosed cargo to lysosomes

J. Paul Luzio, Michael D.J. Parkinson, Sally R. Gray, Nicholas A. Bright

Biochem Soc Trans (2009) 37 (5): 1019–1021.

DOI: https://doi.org/10.1042/BST0371019

Published: 21 September 2009

...J. Paul Luzio; Michael D.J. Parkinson; Sally R. Gray; Nicholas A. Bright In mammalian cells, endocytosed cargo that is internalized through clathrin-coated pits/vesicles passes through early endosomes and then to late endosomes, before delivery to lysosomes for degradation by proteases. Late...

View article titled, The delivery of endocytosed cargo to lysosomes

Articles

ESCRT proteins and the regulation of endocytic delivery to lysosomes

J. Paul Luzio, Siân C. Piper, Katherine Bowers, Michael D.J. Parkinson, Paul J. Lehner, Nicholas A. Bright

Biochem Soc Trans (2009) 37 (1): 178–180.

DOI: https://doi.org/10.1042/BST0370178

Published: 20 January 2009

... vesicles of MVBs (multivesicular bodies). We have focussed on studying the ESCRT requirements for delivery of MHC class I to lysosomes following polyubiquitination by the Kaposi's sarcoma-associated herpesvirus protein K3. Down-regulation of polyubiquitinated cell-surface MHC class I in HeLa cells stably...

View article titled, ESCRT proteins and the regulation of endocytic delivery to lysosomes

Articles

Evolution and assembly of ESCRTs

Sara Ghazi-Tabatabai, Takayuki Obita, Ajaybabu V. Pobbati, Olga Perisic, Rachel Y. Samson, Stephen D. Bell, Roger L. Williams

Biochem Soc Trans (2009) 37 (1): 151–155.

DOI: https://doi.org/10.1042/BST0370151

Published: 20 January 2009

..., cytoskeletal remodelling, protein folding and proteolysis. The AAA Vps (vacuolar protein sorting) 4 is central to traffic to lysosomes, retroviral budding and mammalian cell division. It dissociates ESCRTs (endosomal sorting complexes required for transport) from endosomal membranes, enabling their recycling...

View article titled, Evolution and assembly of ESCRTs

Articles

The role of calcium and other ions in sorting and delivery in the late endocytic pathway

J.P. Luzio, N.A. Bright, P.R. Pryor

Biochem Soc Trans (2007) 35 (5): 1088–1091.

DOI: https://doi.org/10.1042/BST0351088

Published: 25 October 2007

...J.P. Luzio; N.A. Bright; P.R. Pryor The passage of endocytosed receptor-bound ligands and membrane proteins through the endocytic pathway of mammalian cells to lysosomes occurs via early and late endosomes. The latter contain many luminal vesicles and are often referred to as MVBs (multivesicular...

View article titled, The role of calcium and other ions in sorting and delivery in the late endocytic pathway

Articles

MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells

E. Agostinelli, G. Tempera, L. Dalla Vedova, M. Condello, G. Arancia

Biochem Soc Trans (2007) 35 (2): 343–348.

DOI: https://doi.org/10.1042/BST0350343

Published: 20 March 2007

... between sensitive and drug-resistant cells. 1 To whom correspondence should be addressed (email enzo.agostinelli@uniroma1.it ). 25 10 2006 © 2007 The Biochemical Society 2007 hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell...

View article titled, MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells

Articles

NAADP, a new intracellular messenger that mobilizes Ca 2+ from acidic stores

A. Galione

Biochem Soc Trans (2006) 34 (5): 922–926.

DOI: https://doi.org/10.1042/BST0340922

Published: 25 October 2006

...-induced Ca 2+ release from either unfractionated egg homogenates or purified stores. The protocols for isolating the NAADP-sensitive organelles were similar to those describing the purification of reserve granules, organelles related to lysosomes and involved in plasma membrane repair in echinoderm...

View article titled, NAADP, a new intracellular messenger that mobilizes Ca 2+ from acidic stores

Articles

Nucleus–vacuole junctions in yeast: anatomy of a membrane contact site

E. Kvam, D.S. Goldfarb

Biochem Soc Trans (2006) 34 (3): 340–342.

DOI: https://doi.org/10.1042/BST0340340

Published: 22 May 2006

... To whom correspondence should be addressed (email dasg@mail.rochester.edu ). 6 12 2005 © 2006 The Biochemical Society 2006 autophagy endoplasmic reticulum membrane contact site lysosome nuclear envelope nucleus–vacuole junction yeast The ER (endoplasmic reticulum...

View article titled, Nucleus–vacuole junctions in yeast: anatomy of a membrane contact site

Articles

The ubiquitin-proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand

P. van Kerkhof, G. J. Strous

Biochem Soc Trans (2001) 29 (4): 488–493.

DOI: https://doi.org/10.1042/bst0290488

Published: 01 August 2001

... that a GHR truncated at residue 369 can enter the cells in the presence of a proteasome inhibitor, but that the subsequent lysosomal degradation of GH is blocked. Lysosomal inhibitors prolong the half-life of both receptor and ligand. Experiments with antibodies against different receptor tail sections show...

View article titled, The ubiquitin-proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand

NARROW

Insights into the cellular consequences of LRRK2-mediated Rab protein phosphorylation

Mitolysosome exocytosis: a novel mitochondrial quality control pathway linked with parkinsonism-like symptoms

Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

Ca 2+ dialogue between acidic vesicles and ER

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

TPC: the NAADP discovery channel?

Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death

Structural organization of signalling to and from IP 3 receptors

Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease

Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

Rheb and Rags come together at the lysosome to activate mTORC1

Mechanisms of microbial escape from phagocyte killing

LRRK2 and autophagy: a common pathway for disease

Triggering of Ca 2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?

Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Manipulation of the host by pathogens to survive the lysosome

HSP70 and lysosomal storage disorders: novel therapeutic opportunities

Endosome–lysosome fusion

Lysosomal membrane proteins: life between acid and neutral conditions

NAADP as an intracellular messenger regulating lysosomal calcium-release channels

The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes

The delivery of endocytosed cargo to lysosomes

ESCRT proteins and the regulation of endocytic delivery to lysosomes

Evolution and assembly of ESCRTs

The role of calcium and other ions in sorting and delivery in the late endocytic pathway

MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells

NAADP, a new intracellular messenger that mobilizes Ca 2+ from acidic stores

Nucleus–vacuole junctions in yeast: anatomy of a membrane contact site

The ubiquitin-proteasome pathway regulates lysosomal degradation of the growth hormone receptor and its ligand

Email alerts

CONNECT

EXPLORE

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only