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Keywords: lysophosphatidic acid (LPA)
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Biochem Soc Trans (2012) 40 (1): 31–36.
Published: 19 January 2012
... drug discovery lysophosphatidic acid (LPA) 4-pentadecylbenzylphosphonic acid (4-PBA) therapy ATX (autotaxin) is a member of the NPP (nucleotide pyrophosphatase/phosphodiesterase) enzyme family and is also known as NPP2 [ 1 , 2 ]. ATX was originally identified as a secreted phosphatase...
Biochem Soc Trans (2005) 33 (6): 1362–1365.
Published: 26 October 2005
...) lysophosphatidic acid (LPA) phosphatidic acid (PA) prostate cancer For over 50 years, the primary form of therapy for advanced prostate cancer has targeted the androgen receptor. However, there have been few cures and virtually all patients with metastatic prostate cancer treated with androgen...
Biochem Soc Trans (2005) 33 (6): 1366–1369.
Published: 26 October 2005
...A.L. Parrill Lysophosphatidic acid (LPA; 1-acyl-3-phosphoglycerol) exerts its biological activity through both extracellular and intracellular targets. Receptor targets include the cell-surface G-protein-coupled receptors LPA 1–4 and the nuclear PPAR-γ (peroxisome-proliferator-activated receptor γ...
Biochem Soc Trans (2005) 33 (6): 1370–1374.
Published: 26 October 2005
... Burnett C. Makridou P. Hewlett L. Howard K. BMC Biochem. 2004 5 2 50 Zhang N. Sundberg J.P. Gridley T. Genesis 2000 4 137 140 apoptosis lipid phosphate phosphatase (LPP) lysophosphatidic acid (LPA) signalling sphingosine 1-phosphate (S1P...
Biochem Soc Trans (2003) 31 (6): 1209–1212.
Published: 01 December 2003
... 2003 Biochemical Society 2003 cytoskeleton lysophosphatidic acid (LPA) motility phospholipase Rho GTPase Tiam1 Abbreviations used: LPA, lysophosphatidic acid; GPCR, G-protein-coupled receptor; PI 3-kinase, phosphoinositide 3-kinase; EGF, epidermal growth factor; PLD, phospholipase...