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Keywords: lung
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Articles
Biochem Soc Trans (2020) 48 (1): 231–243.
Published: 25 February 2020
... pathways to create the elaborately branched structure of the lung by controlling the directional protrusive movements of cells during branching morphogenesis. PCP operates in the airway epithelium to establish and maintain the orientation of respiratory cilia along the airway axis for anatomically directed...
Articles
Biochem Soc Trans (2018) 46 (3): 707–719.
Published: 25 May 2018
... interactions. Ultimately, through their tight regulation and complex assembly, airway mucins follow the biological rule of ‘form fits function’ in that their structural organization influences their role in lung homeostatic mechanisms. Correspondence: Breanna A. Symmes ( breanna.symmes@UCDenver.edu...
Articles
Biochem Soc Trans (2014) 42 (3): 657–661.
Published: 22 May 2014
...Katherine L. Ordidge; Maria Gregori; Tammy L. Kalber; Mark F. Lythgoe; Sam M. Janes; Adam Giangreco Airway diseases including COPD (chronic obstructive pulmonary disease), cystic fibrosis and lung cancer are leading causes of worldwide morbidity and mortality, with annual healthcare costs...
Articles
Biochem Soc Trans (2009) 37 (4): 855–862.
Published: 22 July 2009
... the respiratory system, the application of microarrays has achieved significant success in all components, particularly with respect to lung cancer. Numerous studies over the last half-decade have applied this technology to the characterization of non-malignant respiratory diseases, animal models of respiratory...
Articles
Biochem Soc Trans (2009) 37 (4): 805–810.
Published: 22 July 2009
...Kewal Asosingh; Serpil C. Erzurum Plasticity of the lung vasculature is intrinsically more complex than other organs due to the presence of two blood supply systems under different arterial pressures, the pulmonary and bronchial arterial systems. The bronchial and pulmonary circulations may both...
Articles
Biochem Soc Trans (2008) 36 (6): 1211–1215.
Published: 19 November 2008
... + T regulatory cells, emphasizing further its role as a negative regulator of inflammation. Interestingly, miR - 146a levels were not increased in tissues obtained from patients with other chronic inflammatory diseases such as the skin from atopic eczema [ 43 ] or lung biopsies from mild asthmatics...
Articles
Biochem Soc Trans (2007) 35 (6): 1492–1495.
Published: 23 November 2007
...I. Sabroe; M.K.B. Whyte The neutrophil is a crucial early defence against microbial infection, but neutrophilic inflammation can result in devastating acute and chronic inflammatory diseases. In the lungs, the neutrophil is a principal part of the pathology of the acute respiratory distress...
Articles
Biochem Soc Trans (2007) 35 (4): 647–651.
Published: 20 July 2007
... To whom correspondence should be addressed (email gjloffice@ucl.ac.uk ). 26 3 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cytokine fibroblast fibrosis integrin lung matrix turnover Chronic disorders of the joints and internal organs are a major...
Articles
Biochem Soc Trans (2007) 35 (4): 807–810.
Published: 20 July 2007
... of animal models. In this transaction, we review recent studies on the utility of siRNA for the investigation of protein function in the airways/lung. We show that, despite previous studies showing the utility of cationic CPPs in vitro , conjugation of siRNA to Tat-(48–60) and penetratin failed to increase...
Articles
Biochem Soc Trans (2007) 35 (3): 527–531.
Published: 22 May 2007
... concentration of nanoparticles and higher reactive surface area per unit mass, alongside unique chemistry and functionality, is important in the acute inflammatory and chronic response. Some animal models have shown that nanoparticles which are deposited in one organ (e.g. lung and gut) may access...
Articles
Biochem Soc Trans (2002) 30 (2): 107–111.
Published: 01 April 2002
...C. D. Richards; C. Kerr; L. Tong; C. Langdon Metabolism of the extracellular matrix (ECM) is a complex process that becomes disregulated in disease states characterized by chronic inflammation of joints, as is seen in rheumatoid arthritis or fibrosis of the lung. The participation of certain...
Articles
Biochem Soc Trans (2002) 30 (2): 211–216.
Published: 01 April 2002
... that activation of the coagulation cascade, with the resultant generation of coagulation proteases, plays a central role in fibrotic lung disease that is associated with acute and chronic lung injury. Consistent with this finding, levels of thrombin are increased in bronchoalveolar lavage fluid from patients...