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Keywords: liver
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Biochem Soc Trans (2021) 49 (2): 579–590.
Published: 05 March 2021
... to the instructive role of pancreatic master regulators in liver to pancreas transdifferentiation and how the recapitulation of the in vivo environment using cell culture techniques can augment their impact in the generation β-cells. Important to normal development is the hierarchical and temporal context...
Biochem Soc Trans (2012) 40 (1): 133–138.
Published: 19 January 2012
...David C. Clarke; Douglas A. Lauffenburger Inflammation is a key physiological response to infection and injury and, although usually beneficial, it can also be damaging to the host. The liver is a prototypical example in this regard because inflammation helps to resolve liver injury, but it also...
Biochem Soc Trans (2010) 38 (6): 1553–1557.
Published: 24 November 2010
... of differentiation. miR - 122 is a highly liver-specific miRNA that is important in hepatitis C virus infection, cholesterol metabolism and hepatocellular carcinoma. In the present review, we discuss the effects of miR - 122 on liver physiology and pathology. Recent evidence of pathways involved in the regulation...
Biochem Soc Trans (2008) 36 (6): 1233–1238.
Published: 19 November 2008
...Svetlana Lutsenko Wilson's disease is a severe human disorder of copper homoeostasis. The disease is associated with various mutations in the ATP7B gene that encodes a copper-transporting ATPase, and a massive accumulation of copper in the liver and several other tissues. The most frequent disease...
Biochem Soc Trans (2008) 36 (5): 848–852.
Published: 19 September 2008
... in methionine metabolism occur in several animal models of alcoholic liver injury, and it is also altered in patients with liver disease. Both high and low levels of SAMe predispose to liver injury. In this regard, knockout mouse models have been developed for the enzymes responsible for SAMe synthesis...
Biochem Soc Trans (2007) 35 (5): 1171–1174.
Published: 25 October 2007
.... Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action. Figure 1 Dose–response curves relating...
Biochem Soc Trans (2007) 35 (5): 1175–1179.
Published: 25 October 2007
... should be addressed (email jbrosnan@mun.ca ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 betaine cystathionine β-synthase diabetes insulin resistance liver trans-sulfuration Since the observation, by McCully [ 1 ], of severe...
Biochem Soc Trans (2006) 34 (6): 1119–1123.
Published: 25 October 2006
...M.C. Wright The PXR (pregnane X receptor) is a nuclear receptor transcription factor that is activated by a range of endobiotics and xenobiotics. The activated PXR modulates the transcription of genes in hepatocytes (the main functional cell of the liver) associated with endobiotic and xenobiotic...
Biochem Soc Trans (2005) 33 (2): 371–374.
Published: 01 April 2005
...B. Leighton; A. Atkinson; M.P. Coghlan The monomeric enzyme GK (glucokinase) has a low affinity for glucose and, quantitatively, is largely expressed in the liver and pancreatic β-cells, playing a key ‘glucose sensing’ role to regulate hepatic glucose balance and insulin secretion. Mutations of GK...
Biochem Soc Trans (2005) 33 (1): 311–315.
Published: 01 February 2005
... peripherally, while it appears impaired in the liver [Goudriaan, Dahlmans, Teusink, Ouwens, Febbraio, Maassen, Romijn, Havekes, and Voshol (2003) J. Lipid. Res. 44 , 2270–2277; and Hajri, Han, Bonen and Abumrad (2002) J. Clin. Invest. 109 , 1381–1389]. Tissues such as muscle, which normally express high levels...
Biochem Soc Trans (2002) 30 (4): 800–802.
Published: 01 August 2002
... representative of the tissue from which they derive. 1 To whom correspondence should be addressed, at Xcellsyz Ltd (E-mail peter@xcellsyz.com ) 9 4 2002 © 2002 Biochemical Society 2002 adipocytes liver muscle t-antigen Biochemical Society Transactions (2002) Volume 30, part 4...
Biochem Soc Trans (2002) 30 (2): 51–54.
Published: 01 April 2002
...David Tosh; Chia-Ning Shen; Jonathan M. W. Slack Transdifferentiation is the name used to describe the conversion of one differentiated cell type to another. During development, the liver and pancreas arise from the same region of the endoderm and cells from the two organs can transdifferentiate...
Biochem Soc Trans (2001) 29 (4): 547–552.
Published: 01 August 2001
...P. Ferré; M. Foretz; D. Azzout-Marniche; D. Bécard; F. Foufelle Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expression...
Biochem Soc Trans (2001) 29 (2): 272–278.
Published: 01 May 2001
... homoeo- ~ ~ Key words : heart, liver, muscle, peroxisome-prolifetator-activated receptor a, pyruvate dehydrogenase, pyruvate dehydrogenase kinase. Abbreviations used: CPT, camitine palmitoyltransferase; FA, fatty acid; PDC, pyruvate dehydrogenase complex: PDK, pyruvate dehydrogenase kinase; PPAR...