... phosphorylation than at prevention or dispersal of filaments. 1 To whom correspondence should be addressed (email C.M.Cowan@soton.ac.uk ). 24 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 Alzheimer's disease axonal transport lithium microtubule...

...Richard P. Bazinet Although lithium has been used therapeutically to treat patients with bipolar disorder for over 50 years, its mechanism of action, as well as that of other drugs used to treat bipolar disorder, is not agreed upon. In the present paper, I review studies in unanaesthetized rats...

...Galila Agam; Yuly Bersudsky; Gerard T. Berry; Diederik Moechars; Yael Lavi-Avnon; R.H. Belmaker Lithium inhibits IMPase (inositol monophosphatase) activity, as well as inositol transporter function. To determine whether one or more of these mechanisms might underlie lithium's behavioural effects...

...S. Hossein Fatemi; Teri J. Reutiman; Timothy D. Folsom Bipolar disorder is a debilitating disorder of the brain with a lifetime prevalence of 1.0% for bipolar I, 1.1% for bipolar II disorder and 2.4–4.7% for subthreshold bipolar disorder. Medications, including lithium, have demonstrated efficacy...

...W. Timothy O'Brien; Peter S. Klein Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is unknown. Lithium directly inhibits GSK3 (glycogen synthase kinase 3), a critical regulator of multiple signal transduction pathways. Inhibition of GSK3 provides...

.... These include PLA 2 (phospholipase A 2 ) [ 34 ] and MAPK (mitogen-activated protein kinase) [ 35 ] signalling pathways, both targeted by VPA and lithium. In the case of several more recent treatments, such as lamotrigine, ion channel regulation remains a common theme [ 36 ]. Our slow advance...

... PRPP synthesis in Saccharomyces cerevisiae Biochem. Soc. Trans. 2005 33 1418 1420 24 O'Donnell T. Rotzinger S. Nakashima T.T. Hanstock C.C. Ulrich M. Silverstone P.H. Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase...

...R. Williams; W.J. Ryves; E.C. Dalton; B. Eickholt; G. Shaltiel; G. Agam; A.J. Harwood Lithium (Li + ), a mood stabilizer, has profound effects on cultured neurons, offering an opportunity to investigate its cellular biological effects. Here we consider the effect of Li + and other psychotropic...