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Keywords: lithium
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Articles
Biochem Soc Trans (2010) 38 (2): 564–570.
Published: 22 March 2010
... in C ). Scale bars, 200 nm. Alzheimer's disease axonal transport lithium microtubule neurofibrillary tangle synapse Axonal microtubules are essential for transport of materials to the synapse [ 1 ]. More than 40 years ago, it was suggested that microtubule-based axonal transport...
Articles
Biochem Soc Trans (2009) 37 (5): 1104–1109.
Published: 21 September 2009
...Richard P. Bazinet Although lithium has been used therapeutically to treat patients with bipolar disorder for over 50 years, its mechanism of action, as well as that of other drugs used to treat bipolar disorder, is not agreed upon. In the present paper, I review studies in unanaesthetized rats...
Articles
Biochem Soc Trans (2009) 37 (5): 1090–1095.
Published: 21 September 2009
...S. Hossein Fatemi; Teri J. Reutiman; Timothy D. Folsom Bipolar disorder is a debilitating disorder of the brain with a lifetime prevalence of 1.0% for bipolar I, 1.1% for bipolar II disorder and 2.4–4.7% for subthreshold bipolar disorder. Medications, including lithium, have demonstrated efficacy...
Articles
Biochem Soc Trans (2009) 37 (5): 1133–1138.
Published: 21 September 2009
...W. Timothy O'Brien; Peter S. Klein Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is unknown. Lithium directly inhibits GSK3 (glycogen synthase kinase 3), a critical regulator of multiple signal transduction pathways. Inhibition of GSK3 provides...
Articles
Biochem Soc Trans (2009) 37 (5): 1077–1079.
Published: 21 September 2009
.... These include PLA 2 (phospholipase A 2 ) [ 34 ] and MAPK (mitogen-activated protein kinase) [ 35 ] signalling pathways, both targeted by VPA and lithium. In the case of several more recent treatments, such as lamotrigine, ion channel regulation remains a common theme [ 36 ]. Our slow advance...
Articles
Biochem Soc Trans (2009) 37 (5): 1121–1125.
Published: 21 September 2009
...Galila Agam; Yuly Bersudsky; Gerard T. Berry; Diederik Moechars; Yael Lavi-Avnon; R.H. Belmaker Lithium inhibits IMPase (inositol monophosphatase) activity, as well as inositol transporter function. To determine whether one or more of these mechanisms might underlie lithium's behavioural effects...
Articles
Biochem Soc Trans (2009) 37 (5): 1115–1120.
Published: 21 September 2009
.... Rotzinger S. Nakashima T.T. Hanstock C.C. Ulrich M. Silverstone P.H. Chronic lithium and sodium valproate both decrease the concentration of myo-inositol and increase the concentration of inositol monophosphates in rat brain Brain Res. 2000 880 84 91 25 Ju S. Shaltiel...
Articles
Biochem Soc Trans (2004) 32 (5): 799–802.
Published: 26 October 2004
...R. Williams; W.J. Ryves; E.C. Dalton; B. Eickholt; G. Shaltiel; G. Agam; A.J. Harwood Lithium (Li + ), a mood stabilizer, has profound effects on cultured neurons, offering an opportunity to investigate its cellular biological effects. Here we consider the effect of Li + and other psychotropic...