.... Protein S-acylation or S-palmitoylation involves the posttranslational addition of fatty acyl chains, typically a palmitate (C16:0), to cysteine residues of proteins via thioester linkages ( Figure 1A ). In contrast with other forms of protein lipidation, S-palmitoylation is uniquely reversible due...

... and sequesters Hh spreading by endocytotic internalization and the activation of HhNp degradation [ 15 , 16 ]. Although Ptc contains the sterol-sensing domain (SSD; similar to proteins involved in cholesterol biogenesis, homoeostasis or lipid storage) [ 17 ], ShhNp and ShhN have comparable binding affinities...