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Keywords: lipid A
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Biochem Soc Trans (2010) 38 (5): 1390–1395.
Published: 24 September 2010
... with crystallographic data of MD-2 bound to TLR4 antagonists Lipid IVa [ 20 ] and Eritoran [ 21 ], has revealed some fundamental structural aspects of the TLR4 dimerization process and the molecular basis of TLR4 agonism and antagonism ( Figure 1 ). Figure 1 ( A ) Structure of the (TLR4–MD-2–LPS) 2 complex from...
Biochem Soc Trans (2009) 37 (4): 863–867.
Published: 22 July 2009
... such as antibiotic resistance, biofilm formation, antimicrobial peptide resistance and pro-inflammatory lipid A structures. Lipid A is a component of the lipopolysaccharide cell wall present on bacteria and is recognized by TLR4 (Toll-like receptor 4). Its detection elicits a pro-inflammatory response...