... and cancer treatments, defensins uniquely target specific membrane lipids via mechanisms distinct from other HDPs. Therefore, defensins could be potentially developed as therapeutics with increased selectivity and reduced susceptibility to the resistance mechanisms of tumour cells and infectious pathogens...

...Ben J. Boyd; Andrew J. Clulow This review will focus on orally administered lipid-based drug delivery vehicles and specifically the influence of lipid digestion on the structure of the carrier lipids and their entrained drug cargoes. Digestion of the formulation lipids, which are typically apolar...

...Robin A. Corey; Phillip J. Stansfeld; Mark S.P. Sansom Membranes are formed from a bilayer containing diverse lipid species with which membrane proteins interact. Integral, membrane proteins are embedded in this bilayer, where they interact with lipids from their surroundings, whilst peripheral...

... and PM proliferation. On the basis of these mutant phenotypes, we have hypothesized previously that the defects in cell wall formation and PM morphology observed in drp1 mutants results from defects in the endocytic trafficking of PM lipids and proteins, including enzymes involved in cell wall...

... potentials. A PIP 2 -binding pocket seems to comprise a part of the TRP domain and especially pleckstrin homology domains in the C-terminus. 1 To whom correspondence should be addressed (email bernd.nilius@med.kuleuven.be ). 24 7 2006 © 2007 The Biochemical Society 2007 lipid...

...F.R. Maxfield; M. Mondal The pathways involved in the intracellular transport and distribution of lipids in general, and sterols in particular, are poorly understood. Cholesterol plays a major role in modulating membrane bilayer structure and important cellular functions, including signal...

... the membrane lipids. X-ray crystallography has provided high-resolution structures for PS-I and the purple bacterial reaction centre, and revealed binding sites for a number of lipids, either embedded in the protein interior or attached to the protein surface. These lipids play a variety of roles, including...

... to these organelles, which is regulated by specific lipid and protein motifs. PtdSer transport to mitochondria is controlled by ubiquitination via the action of the ubiquitin ligase subunit Met30p (a ubiquitin ligase subunit encoded by the MET30 gene that complements the met30 mutation affecting methionine...

...C. Hunte Many membrane proteins selectively bind defined lipid species. This specificity has an impact on correct insertion, folding, structural integrity and full functionality of the protein. How are these different tasks achieved? Recent advances in structural research of membrane proteins...

... can also be visualized in ultrathin sections; they exhibit highly different staining intensities. Biochemical analysis proves the presence of lipids as well as membrane proteins. Various derivatives of the archaeal lipid ‘archaeol’ could be identified, many of which were glycosylated. The protein set...

... of fatty-acid-binding proteins inside enterocytes is provided. 1 To whom correspondence should be addressed (e-mail tsopp@email.uc.edu ). 44th International Conference on the Bioscience of Lipids, a meeting held at Keble College, Oxford, 7–11 September 2003 7 September 2003 © 2004...

... of these components in regulating lipid metabolism in plants. Using a range of down-regulated plants, it has become clear that down-regulation of these genes also causes down-regulation of other components of lipid metabolism, at the activity, translational and transcriptional levels. These plants exhibit effects...

... in other complex lipids. Both with and without oleoyl-CoA the label in PtdH rapidly decreased whereas the radioactivity in DAG and T A G increased sequentially. Little difference in the label which accumulated in T A G was observed in the presence or absence of oleoyl-CoA (Fig- ure 2). The experiments...

..., and detected fluorometrically. We report the composition and concentration of the acyl-CoA pool in mature A. thaliana leaves, and during storage-lipid breakdown in 2-day-old seedlings. The concentrations measured were in the 1–4 μM range for both tissue types. To our knowledge, this is the first time...

.... Further, we show that significant PDAT activity is also present in vegetative tissues of Arabidopsis thaliana. 1 To whom correspondence should be addressed (e-mail antoni.banas@w.slu.se ) 26 6 2000 © 2000 Biochemical Society 2000 cholinephosphotransferase lipid phospholipases...

...A. Banaś; A. Dahlqvist; H. Dêbski; P.-O. Gummeson; S. Stymne Lipids, proteins and starch are the main storage products in oat seeds. As a first step in elucidating the regulatory mechanisms behind the deposition of these compounds, two different oat varieties, ‘Freja’ and ‘Matilda’, were analysed...

... sequence of chromosome II was released, allowing us to make assumptions on candidate genes based on map location. We are currently sequencing the putative genes. D D Complex Lipid Biosynthesis: The Kennedy Pathway Complex Lipid Biosynthesis Colloquium Organized and Edited by J. Harwood (School...

...C. Sellwood; A. R. Slabas; S. Rawsthorne Acetyl-CoA carboxylase I (ACCase I) in developing oilseed rape embryos is predominantly cystosolic, based upon measurement of its propionyl-CoA carboxylase activity. Reduction of ACCase I by antisense expression reduces seed lipid content and affects...

... correspondence should be addressed (e-mail nbrooker@pittstate.edu ) 19 6 2000 © 2000 Biochemical Society 2000 lipid Macrophomina natural product terpenoid Environmental Effects on Lipids: Other Stresses and Disease therefore do not correspond to the PAP-1 isoform, which is either...

...P.J. Eastmond; I. A. Graham In germinating oilseeds peroxisomal fatty acid β-oxidation is responsible for the mobilization of storage lipids. This pathway also occurs in other tissues where it has a variety of additional physiological functions. The central enzymatic steps of peroxisomal β...