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Keywords: ligand binding domainClose
Journal: Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2333–2343.
Published: 28 October 2021
... domain (DBD), and a C-terminal ligand binding domain (LBD) connected by a flexible hinge region ( Figure 1A ). The NTD contains an activation function-1 (AF-1) region required for full transcriptional activity. In the absence of ligand, GR is bound to heat shock proteins and sequestered in the cytoplasm...