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Keywords: leucocyte
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Articles
Biochem Soc Trans (2008) 36 (2): 203–211.
Published: 20 March 2008
...Sarah Garrido-Urbani; Paul F. Bradfield; Boris P.-L. Lee; Beat A. Imhof Rapid mobilization of leucocytes through endothelial and epithelial barriers is key in immune system reactivity. The underlying mechanisms that regulate these processes have been the basis for many recent studies. Traditionally...
Articles
Biochem Soc Trans (2007) 35 (5): 1161–1162.
Published: 25 October 2007
...H.M. McGettrick; A. Filer; G.E. Rainger; C.D. Buckley; G.B. Nash Vascular endothelial cells play a pivotal role in regulating leucocyte recruitment during inflammation, and their responses can be modulated by their local environment, including cells of the tissue stroma. We have developed a model...
Articles
Biochem Soc Trans (2007) 35 (3): 466–469.
Published: 22 May 2007
... inflammatory disease. Many studies have shown that the process of atherogenesis in part starts with the interaction between the activated leucocytes and activated endothelium. Postprandial lipoproteins can activate leucocytes in the blood and up-regulate the expression of leucocyte adhesion molecules...
Articles
Biochem Soc Trans (2006) 34 (6): 1002–1004.
Published: 25 October 2006
... inflammation. We provide evidence that expression of D6 is not limited to the lymphatic endothelium at sites of inflammation as previously believed. Instead we postulate that D6 expression in leucocytes may have a significant impact upon chemokine bioavailability during the resolution phase of inflammation. D6...
Articles
Biochem Soc Trans (2006) 34 (6): 1313–1317.
Published: 25 October 2006
..., reclassification of stroke type and prognosis, and vascular disease risk. If these conditions are met, then it should be possible to develop cost-effective and rapid assays. 1 email bairda@ninds.nih.gov blood genomic profiling gene expression profiling ischaemic stroke leucocyte peripheral blood...
Articles
Biochem Soc Trans (2006) 34 (6): 1009–1013.
Published: 25 October 2006
...C.A.H. Hansell; C.V. Simpson; R.J.B. Nibbs Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chemoattractants, are of fundamental importance in this process, directing...
Articles
Biochem Soc Trans (2006) 34 (6): 1024–1027.
Published: 25 October 2006
... receptor 9) ligation. Thus CD33-related siglecs are able to mediate diverse inhibitory functions of leucocytes in the innate immune system via both ITIM-dependent and -independent pathways. 1 To whom correspondence should be addressed (email p.r.crocker@dundee.ac.uk ). 31 7 2006 © 2006...
Articles
Biochem Soc Trans (2006) 34 (6): 1014–1017.
Published: 25 October 2006
...E.M. Borroni; C. Buracchi; Y. Martinez de la Torre; E. Galliera; A. Vecchi; R. Bonecchi; A. Mantovani; M. Locati Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes ‘silent’ receptors with distinct specificity and tissue...
Articles
Biochem Soc Trans (2005) 33 (2): 406–408.
Published: 01 April 2005
... dynamically to various stimuli, and controls a complex series of cellular reactions and interactions. The current presentation describes the use of computer enhanced video recording to study interactions between endothelial cells and circulating blood cells, especially leucocytes. Subsequently, modern assays...
Articles
Biochem Soc Trans (2004) 32 (6): 1118–1121.
Published: 26 October 2004
...A. Ivetic; A.J. Ridley L-selectin is constitutively expressed on the surface of most leucocytes and is important for tethering and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs (e.g. naive T cells) and sites of inflammation (e.g...
Articles
Biochem Soc Trans (2004) 32 (3): 507–510.
Published: 01 June 2004
... by the extravasated neutrophil. In the present paper, we review the novel proapoptotic effect of ANXA1 and discuss its potential with respect to the pathophysiology of inflammation and leucocyte recruitment. 1 To whom correspondence should be addressed (email M.Perretti@qmul.ac.uk ). Apoptosis in Myeloid...
Articles
Biochem Soc Trans (2004) 32 (2): 366–377.
Published: 01 April 2004
..., and from viral infection to cancer. Genetic and pharmacological studies have shown that chemokines are responsible for the excessive recruitment of leucocytes to inflammatory sites and damaged tissue. In the present paper, we discuss the rationale behind interfering with the chemokine system and introduce...