... , J. , Bolliger , M.F. , Memou , A. , Narasimha , S. , Molitor , T.P. et al. ( 2018 ) P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity . Biochem. J. 475 , 1271 – 1293 10.1042/BCJ20170699 115 Matsui , T...

...Jillian H. Kluss; Adamantios Mamais; Mark R. Cookson The past two decades in research has revealed the importance of leucine-rich repeat kinase 2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families, mutations in LRRK2 can cause PD with age-dependent but variable...

...)00583-6 12 Westerlund , M. , Belin , A.C. , Anvret , A. , Bickford , P. , Olson , L. and Galter , D. ( 2008 ) Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: implications for Parkinson's disease...

...Laura Civiero; Susanna Cogo; Alice Biosa; Elisa Greggio Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely...

...Mattia Volta; Heather Melrose Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of familial Parkinson's disease (PD), resembling the sporadic disorder. Intensive effort has been directed toward LRRK2 mouse modeling and investigation, aimed at reproducing the human...

...Md. Shariful Islam; Darren J. Moore Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are the most common cause of familial Parkinson's disease (PD) with autosomal dominant inheritance. Accordingly, LRRK2 has emerged as a promising therapeutic target for disease modification in PD. Since...

...Heyne Lee; William S. James; Sally A. Cowley Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are found in familial and idiopathic cases of Parkinson's disease (PD), but are also associated with immune-related disorders, notably Crohn's disease and leprosy. Although the physiological...

...Claudia Manzoni A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at different times and places...

...Jesús Madero-Pérez; Elena Fdez; Belén Fernández; Antonio Jesús Lara Ordóñez; Marian Blanca Ramírez; María Romo Lozano; Pilar Rivero-Ríos; Sabine Hilfiker Leucine-rich repeat kinase 2 (LRRK2) is a key player in the pathogenesis of Parkinson's disease. Mutations in LRRK2 are associated with increased...

...Marian Blanca Ramírez; Antonio Jesús Lara Ordóñez; Elena Fdez; Sabine Hilfiker Mutations in the Leucine-Rich Repeat Kinase 2 ( LRRK2 ) gene are intimately linked to both familial and sporadic Parkinson's disease. LRRK2 is a large protein kinase able to bind and hydrolyse GTP. A wealth of in vitro...

...Heather Mortiboys After the discovery of leucine-rich repeat kinase 2 (LRRK2) as a risk factor for sporadic Parkinson's disease (PD) and mutations in LRRK2 as a cause of some forms of familial PD, there has been substantial interest in finding chemical modulators of LRRK2 function. Most...

...Jonathon Nixon-Abell; Daniel C. Berwick; Kirsten Harvey Leucine-rich repeat kinase 2 (LRRK2) is a central protein in the pathogenesis of Parkinson's disease (PD), yet its normal function has proved stubbornly hard to elucidate. Even though it remains unclear how pathogenic mutations affect LRRK2...

...Giambattista Guaitoli; Bernd K. Gilsbach; Francesco Raimondi; Christian Johannes Gloeckner Mutations within the leucine-rich repeat kinase 2 ( LRRK2 ) gene represent the most common cause of Mendelian forms of Parkinson's disease, among autosomal dominant cases. Its gene product, LRRK2, is a large...