...Peter R. Moult; Jenni Harvey It is well established that leptin is a circulating hormone that enters the brain and regulates food intake and body weight via its hypothalamic actions. However, it is also known that leptin receptors are widely expressed in the CNS (central nervous system...

... common diseases. The moral reason is obvious: such individuals are seriously afflicted, with shortened lifespan and poor quality of life, and compassion dictates that we as physicians should give them disproportionate attention. diet insulin resistance leptin obesity peroxisome-proliferator...

...J. Harvey; L.J. Shanley; D. O'Malley; A.J. Irving It is well documented that the hormone leptin signals information regarding the status of fat stores to hypothalamic nuclei, which in turn control feeding behaviour and body weight. However, leptin and its receptor are widely expressed in many extra...

... with insulin resistance, the idea has emerged that certain adipokines might influence insulin action. Among these, tumour necrosis factor α, interleukin-6 and resistin are increased in the obese state and interfere negatively with insulin-mediated processes. Conversely, leptin and adiponectin exert an insulin...

...Y. Minokoshi; B.B. Kahn Leptin regulates energy homoeostasis through central and peripheral mechanisms. Initial steps in leptin action include signalling through a cytokine-like receptor which activates the JAK/STAT pathway. We investigated whether the metabolic effects of leptin in muscle could...

... a large increase in heat production. These adaptations are nutritionally sensitive, and may be mediated in part by rapid changes in prolactin and leptin secretion after birth. Restriction of maternal nutrition reduces adipose tissue deposition, with no effect on UCP1. Increased maternal food intake...

...M. E. Symonds; A. Mostyn; T. Stephenson The cytokine receptors for growth hormone (GH), prolactin and leptin have a critical role in regulating embryo, placental and/or fetal development, which is dependent on stage of gestation and species. GH and prolactin receptors are detectable from conception...

... before birth which may play an important role in precocial species in the successful transition of the fetus to extra-uterine life. fetus growth hormone leptin prolactin prolactin receptor GH, growth hormone GHR, growth hormone receptor IGF, insulin-like growth factor PRL, prolactin PRLR...

... in the obese state. Protein production is, as a metabolic activity, subject to regional variations. In particular, the production of leptin, angiotensinogen, interleukin-6 and plasmin activator inhibitor-1 differs between subcutaneous and visceral adipose tissue sites, but no regional differences have been...