...Ezequiel Nazer Lamins are components of the nuclear lamina, a protein meshwork that underlies the nuclear membrane. Lamins interact with chromatin in transcriptionally silent regions defined as lamina-associated-domains (LADs). However, recent studies have shown that lamins regulate active...

...Erin M. Bank; Yosef Gruenbaum In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact...

... in these processes. Lamina mutations lead to a number of diseases, known as laminopathies, that include premature aging [HGPS (Hutchinson–Gilford progeria syndrome)], other progressive diseases and dystrophies of various tissues [ 28 ]. HGPS is caused by a mutation in the gene encoding human A-type lamin, LMNA...

... facilitated by NPCs (nuclear pore complexes). Recently, it has been indicated that signals can be transmitted from the cytoskeleton to the intranuclear structures via interlinking transmembrane proteins. In animal cells, the nuclear lamina tightly underlies the inner nuclear membrane and thus represents...

...Tatiana V. Cohen; Lidia Hernandez; Colin L. Stewart Recent findings that some 24 inherited diseases and anomalies are caused by defects in proteins of the NE (nuclear envelope) and lamina have resulted in a fundamental reassessment of the functions of the NE and underlying lamina. Instead of just...