1-4 of 4
Keywords: lamin A
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Biochem Soc Trans (2020) 48 (3): 981–991.
Published: 15 June 2020
...Oliver Dreesen The metazoan nucleus is equipped with a meshwork of intermediate filament proteins called the A- and B-type lamins. Lamins lie beneath the inner nuclear membrane and serve as a nexus to maintain the architectural integrity of the nucleus, chromatin organization, DNA repair...
Biochem Soc Trans (2011) 39 (6): 1764–1769.
Published: 21 November 2011
..., a mutant lamin A protein derived from a splicing variant of the lamin A/C gene ( LMNA ). Progerin causes chromatin perturbations which result in the formation of DSBs (double-strand breaks) and abnormal DDR (DNA-damage response). In the present article, we review recent findings which resolve some...
Biochem Soc Trans (2010) 38 (1): 281–286.
Published: 19 January 2010
...Dawn T. Smallwood; Sue Shackleton HGPS (Hutchinson–Gilford progeria syndrome) is a severe childhood disorder that appears to mimic an accelerated aging process. The disease is most commonly caused by gene mutations that disrupt the normal post-translational processing of lamin A, a structural...
Biochem Soc Trans (2008) 36 (6): 1389–1392.
Published: 19 November 2008
...Gemma S. Beard; Joanna M. Bridger; Ian R. Kill; David R.P. Tree The laminopathy Hutchinson–Gilford progeria syndrome (HGPS) is caused by the mutant lamin A protein progerin and leads to premature aging of affected children. Despite numerous cell biological and biochemical insights into the basis...