... to oppose activation of the pathway. knockout mice nuclear factor kappaB phosphorylation/dephosphorylation T-cells Protein phosphatase-6 (PP6) is a member of the PPP family of protein Ser/Thr phosphatases, enzymes with a bimetallic (Fe::Zn) catalytic center that distinguish them in terms...

... encoding NDST-1 or NDST-2 has been knocked out. NDST-1 knockout mice with altered HS structure die at birth due to lung failure, whereas lack of NDST-2 results in abnormal mast cells. Since NDSTs have a key role in HS design (see above), these mice can be used to study HS function. Areas of interest...

... proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux. 1 E-mail martin.turner@bbsrc.ac.uk 15 4 2002 © 2002 Biochemical Society 2002 calcium knockout mice lymphocyte activation BCR, B-cell...