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Articles

Guwiyang Wurra –‘Fire Mouse’: a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies

Ryan J. Middleton, Guo-Jun Liu, Richard B. Banati
Journal: Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 553–558.
DOI: https://doi.org/10.1042/BST20150039
Published: 03 August 2015
... obtained from the recently generated Tspo knockout mouse models. In addition to defining the role of TSPO/PBR, we also describe the value of Tspo knockout mice in determining the selectivity, specificity and presence of any off-target effects of TSPO/PBR ligands. 1 To whom correspondence should...
View article titled, Guwiyang Wurra –‘Fire Mouse’: a global gene <span class="search-highlight">knockout</span> model for TSPO&#x2F;PBR drug development, loss-of-function and mechanisms of compensation studies
Click here to open pdf in another window PDF for Guwiyang Wurra –‘Fire Mouse’: a global gene <span class="search-highlight">knockout</span> model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies
Articles

Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function

Xavier Fant, Kumiko Samejima, Ana Carvalho, Hiromi Ogawa, Zhenjie Xu, Zuojun Yue, William C. Earnshaw, Sandrine Ruchaud
Journal: Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1655–1659.
DOI: https://doi.org/10.1042/BST0381655
Published: 24 November 2010
... describe how we generated DT40 conditional-knockout cell lines for incenp1 and survivin1 to better understand the role of these CPC subunits in the control of Aurora B kinase activity. These lines enabled us to reassess current knowledge of survivin function and to show that INCENP acts as a rheostat...
View article titled, Use of DT40 conditional-<span class="search-highlight">knockout</span> cell lines to study chromosomal passenger protein function
Click here to open pdf in another window PDF for Use of DT40 conditional-<span class="search-highlight">knockout</span> cell lines to study chromosomal passenger protein function