...Akanksha Baharani; Brett Trost; Anthony Kusalik; Scott Napper There is increasing appreciation among researchers and clinicians of the value of investigating biology and pathobiology at the level of cellular kinase (kinome) activity. Kinome analysis provides valuable opportunity to gain insights...

... nevertheless have yielded only limited success with many different malignancies due to the inability of single agents to sustain a durable clinical response. Cancer cell kinomes are highly resilient and able to bypass targeted kinase inhibition, leading to tumour resistance. A novel platform has been developed...

... signalling functions of pseudokinases in their physiological environments. The first human kinome analysis produced the conclusion that “surprisingly, nearly 10% of all kinase domains appear to lack catalytic activity. However, these domains are otherwise well conserved and are likely to maintain...