..., substantial progress has been made in identifying components of both the kinetochore and the mitotic spindle that generate the force to move mitotic chromosomes. Additionally, we now have a reasonable, albeit incomplete, understanding of the molecular and biochemical events that are involved in establishing...

...John C. Meadows Correct transmission of genetic information from mother to daughter cells is necessary for development and survival. Accurate segregation is achieved by bipolar attachment of sister kinetochores in each chromatid pair to spindle microtubules emanating from opposite spindle poles...

...Fekret Osman; Matthew C. Whitby Centromere proteins CENP-S and CENP-X are members of the constitutive centromere-associated network, which is a conserved group of proteins that are needed for the assembly and function of kinetochores at centromeres. Intriguingly CENP-S and CENP-X have alter egos...

...Hiroshi Sato; Shigeaki Saitoh The kinetochore, which forms on a specific chromosomal locus called the centromere, mediates interactions between the chromosome and the spindle during mitosis and meiosis. Abnormal chromosome rearrangements and/or neocentromere formation can cause the presence...

...María Dolores Vázquez-Novelle; Lesia Mirchenko; Frank Uhlmann; Mark Petronczki Two closely connected mechanisms safeguard the fidelity of chromosome segregation in eukaryotic cells. The mitotic checkpoint monitors the attachment of kinetochores to microtubules and delays anaphase onset until all...

...Bernardo Orr; Olga Afonso; Tália Feijão; Claudio E. Sunkel The kinetochore is a complex molecular machine that serves as the interface between sister chromatids and the mitotic spindle. The kinetochore assembles at a particular chromosomal locus, the centromere, which is essential to maintain...

... of these kinases in maintaining chromosomal stability. Essential for the assembly of an APC/C inhibitor by unattached kinetochores is the activation of Mad2 by dimerization with a Mad1–Mad2 heterodimer that is stably bound to unattached kinetochores. This dimerization converts an inactive Mad2 molecule...

... transport receptors, thereby promoting organization of mitotic spindles with respect to chromosomes. In addition to this role of soluble Ran-GTP, Ran has two important but less understood roles at mitotic kinetochores. Namely, it is essential for regulation of the spindle assembly checkpoint...