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Keywords: kinetics
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Articles
Biochem Soc Trans (2009) 37 (2): 333–335.
Published: 20 March 2009
.... Hothi P. Johanissen L.O. Masgrau L. Pang J. Leys D. Sutcliffe M.J. Scrutton N.S. Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular...
Articles
Biochem Soc Trans (2007) 35 (4): 733–736.
Published: 20 July 2007
... efficacy D 2 dopamine receptor G-protein-coupled receptor (GPCR) G-protein cycle guanosine 5′-[γ-[ 35 S]thio]triphosphate-binding assay ([ 35 S]GTP[S]-binding assay) kinetics The actions of drugs at receptors depend on two events: the binding of the drug to the receptor and the response...
Articles
Biochem Soc Trans (2007) 35 (3): 482–483.
Published: 22 May 2007
.... There is therefore a need to establish a specific measure of the kinetics of endogenous and exogenous TAG in the postprandial period. 1 To whom correspondence should be addressed (email f.sun@surrey.ac.uk ). 11 1 2007 © 2007 Biochemical Society 2007 apolipoprotein kinetics postprandial...
Articles
Biochem Soc Trans (2004) 32 (6): 1045–1047.
Published: 26 October 2004
...A. Benians; M. Nobles; A. Tinker The RGS (regulators of G-protein signalling) protein family sharpen signalling kinetics through heterotrimeric G-proteins by enhancing the GTPase activity of the G-protein α subunit. Paradoxically, they also accelerate receptor-stimulated activation. We investigated...
Articles
Biochem Soc Trans (2004) 32 (6): 1029–1031.
Published: 26 October 2004
...C. Krasel; J.-P. Vilardaga; M. Bünemann; M.J. Lohse The kinetics of G-protein-coupled receptor activation and deactivation has, so far, been measured only indirectly, most frequently by assessing the production of various second messengers. We have developed methods based on fluorescence resonance...
Articles
Biochem Soc Trans (2004) 32 (5): 873–877.
Published: 26 October 2004
... interaction drug discovery G-protein-coupled receptor kinetics ternary complex model The GPCRs (G-protein-coupled receptors) are the largest receptor superfamily and are extremely tractable drug targets. Traditional approaches to drug discovery at GPCRs focus on mimicking or inhibiting the actions...
Articles
Biochem Soc Trans (2003) 31 (6): 1367–1371.
Published: 01 December 2003
...M.J.C. Crabbe Kinetic studies on the AR (aldose reductase) protein have shown that it does not behave as a classical enzyme in relation to ring aldose sugars. As with non-enzymatic glycation reactions, there is probably a free-radical element involved derived from monosaccharide autoxidation...
Articles
Biochem Soc Trans (2003) 31 (5): 990–996.
Published: 01 October 2003
... imaging kinetics membrane potential Abbreviations used: ϕ m , transmembrane potential difference; ϕ s , membrane surface potential; ϕ d , membrane dipole potential; FPE, fluorescein phosphatidylethanolamine; FHCVF, Flory-Huggins Corrected Volume-Fraction; GPCR, G-protein-coupled receptor; di...
Articles
Biochem Soc Trans (2003) 31 (3): 497–501.
Published: 01 June 2003
... flavoprotein kinetics Abbreviations used: CPR, cytochrome P450 reductase; hq, hydroquinone; ox, oxidized; sq, semiquinone. Enzyme Mechanism A Structural Perspective 497 Electron transfer in human cytochrome P450 reductase A. Gutierrez*, A. Grunau*, M. Paine , A.W. Munro*, C.R. Wolf , G.C.K...
Articles
Biochem Soc Trans (2003) 31 (3): 719–722.
Published: 01 June 2003
...A.G. McDonald Of the many examples of oscillatory kinetic behaviour known, several are briefly reviewed, including those of glycolysis, the peroxidase–oxidase reaction and oscillations in cellular calcium concentration. It is shown that simple mathematical models employing allosteric rate laws...
Articles
Biochem Soc Trans (2002) 30 (2): 30–38.
Published: 01 April 2002
... the severe decrease in the enzyme activity characteristic of TPI deficiency nor the enhanced ability of the mutant enzyme from haemolysate of the propositus to associate with subcellular particles. Here we present kinetic (flux analysis), thermodynamic (microcalorimetry and fluorescence spectroscopy...