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Keywords: kinesin
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Biochem Soc Trans (2018) 46 (4): 967–982.
Published: 31 July 2018
... in motile and sensory cilia ( Box 1 ) [ 22 ]. The IFT system moves axonemal building blocks, regulatory proteins, and signaling molecules within the cilium [ 23 – 26 ] and powers surface gliding locomotion of protozoa [ 27 , 28 ]. It involves the interplay of dynein-2 with plus-end-directed kinesin-II...
Biochem Soc Trans (2015) 43 (1): 79–83.
Published: 26 January 2015
...Alice Bachmann; Anne Straube Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly...
Biochem Soc Trans (2013) 41 (6): 1761–1765.
Published: 20 November 2013
..., a process known as chromosome bi-orientation. Achieving this requires dynamic interplay between kinetochore proteins, kinesin motor proteins and cell cycle regulators. Chromosome bi-orientation is monitored by a surveillance mechanism known as the SAC (spindle assembly checkpoint). The Aurora B kinase...
Biochem Soc Trans (2012) 40 (2): 438–443.
Published: 21 March 2012
...George M. Jeppesen; J.K. Heinrich Hoerber During the last 25 years, a vast amount of research has gone into understanding the mechanochemical cycle of kinesin-1 and similar processive motor proteins. An experimental method that has been widely used to this effect is the in vitro study of kinesin-1...
Includes: Multimedia, Supplementary data
Biochem Soc Trans (2011) 39 (5): 1142–1148.
Published: 21 September 2011
...Michelle Peckham Cytoskeletal motors include myosins, kinesins and dyneins. Myosins move along tracks of actin filaments, whereas kinesins and dyneins move along microtubules. Many of these motors are involved in trafficking cargo in cells. However, myosins are mostly monomeric, whereas kinesins...
Biochem Soc Trans (2011) 39 (5): 1191–1196.
Published: 21 September 2011
... is regulated by the activity of organelle-associated motor proteins, kinesins, dyneins and myosins, which move cargo along polar MT (microtubule) and actin tracks. However, in most instances, the motors that move specific organelles remain mysterious. Over recent years, pigment granules, or melanosomes, within...
Biochem Soc Trans (2011) 39 (5): 1202–1206.
Published: 21 September 2011
..., include vesicle motility. Microtubule-based kinesin and cytoplasmic dynein motor complexes are prominent among the classes of known Rab effector proteins. Additionally, many Rabs associate with microtubule-based motors via effectors that act as adaptor molecules that can simultaneously associate...
Biochem Soc Trans (2011) 39 (5): 1120–1125.
Published: 21 September 2011
... transport) in which IFT cargoes are transported along axonemal microtubules by kinesin and dynein motors. A variety of genetic, biochemical and cell biological approaches has established the heterotrimeric kinesin-2 motor as the ‘core’ IFT motor, whereas other members of the kinesin-2, kinesin-3 and kinesin...
Biochem Soc Trans (2011) 39 (5): 1126–1130.
Published: 21 September 2011
...@northwestern.edu ). 5 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 bidirectional intracellular transport cargo transport dynein kinesin microtubule cytoskeleton myosin Molecular motors belonging to the kinesin, dynein and myosin families are responsible...
Biochem Soc Trans (2010) 38 (1): 205–208.
Published: 19 January 2010
...Angela McDonald; Sarah Fogarty; Isabelle Leclerc; Elaine V. Hill; D. Grahame Hardie; Guy A. Rutter Glucose-stimulated insulin secretion from pancreatic β-cells requires the kinesin-1/Kif5B-mediated transport of insulin granules along microtubules. 5′-AMPK (5′-AMP-activated protein kinase...
Biochem Soc Trans (2009) 37 (5): 961–965.
Published: 21 September 2009
..., or ER tubules can move along microutubles via the microtubule motors dynein and kinesin-1. Alternatively, ER tubules can be extended by attaching to growing microtubule tips (indicated by +), mediated by the interaction between the ER protein STIM1 and the plus end-binding protein EB1. ©...
Biochem Soc Trans (2006) 34 (1): 48–50.
Published: 20 January 2006
...K. Pozo; F.A. Stephenson GRIF-1 [GABA A (γ-aminobutyric acid A ) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail...
Biochem Soc Trans (2002) 30 (2): 328–332.
Published: 01 April 2002
...A. Varadi; E. K. Ainscow; V. J. Allan; G. A. Rutter Glucose stimulates the release of insulin in part by activating the recruitment of secretory vesicles to the cell surface. While this movement is known to be microtubule-dependent, the molecular motors involved are undefined. Active kinesin...