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Keywords: kinase inhibitor
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Biochem Soc Trans (2014) 42 (4): 765–769.
Published: 11 August 2014
...Jon S. Zawistowski; Lee M. Graves; Gary L. Johnson Cancer cells are dependent on protein kinase signalling networks to drive proliferation and to promote survival, and, accordingly, kinases continue to represent a major target class for development of anti-cancer therapeutics. Kinase inhibitors...
Biochem Soc Trans (2013) 41 (4): 1083–1088.
Published: 18 July 2013
... receptor (EGFR) kinase kinase inhibitor protein kinase A (PKA) pseudokinase The eukaryotic cell is a staggeringly complex environment, with intricate regulatory mechanisms underpinning every aspect of its behaviour. At the heart of many of these regulatory mechanisms is the requirement...
Biochem Soc Trans (2010) 38 (4): 1067–1071.
Published: 26 July 2010
... for chemical screening, and describe methods for a simple high-content live-image-based platform. We report the effects of a panel of 160 kinase inhibitors (Inhibitor Select I and II; Calbiochem) on NES cells, identifying three inhibitors of ROCK (Rho-associated kinase) as promoting the expansion of NES cell...
Biochem Soc Trans (2006) 34 (6): 1303–1306.
Published: 25 October 2006
... to untimely and pathogenic cell survival. 1 To whom correspondence should be addressed (email lorenzo.pinna@unipd.it ). 23 6 2006 © 2006 The Biochemical Society 2006 apoptosis consensus sequence druggable kinome kinase inhibitor phosphoproteome protein kinase CK2 Nearly...