1-21 of 21
Keywords: kinase
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem Soc Trans (2022) 50 (4): 1207–1224.
Published: 23 August 2022
...Nicole J. Van Bergen; Sean Massey; Anita Quigley; Ben Rollo; Alexander R. Harris; Robert M.I. Kapsa; John Christodoulou CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is caused by pathogenic variants in the cyclin-dependent kinase-like 5 ( CDKL5 ) gene...
Articles
Biochem Soc Trans (2020) 48 (1): 179–185.
Published: 12 February 2020
...Jessica P. Elmore; Michael C. McGee; Natalie F. Nidetz; Orchi Anannya; Weishan Huang; Avery August CD4 + effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase...
Articles
Biochem Soc Trans (2019) 47 (5): 1471–1479.
Published: 24 September 2019
... of driver mutations that distinguish them from adult gliomas and define new opportunity for the development of precision medicines. The specific association of ACVR1 mutations with DIPG tumours suggests a direct link to neurodevelopment and highlights the encoded bone morphogenetic protein receptor kinase...
Articles
Biochem Soc Trans (2019) 47 (3): 897–908.
Published: 30 May 2019
...Katharina M. Siess; Thomas A. Leonard Akt is an essential protein kinase activated downstream of phosphoinositide 3-kinase and frequently hyperactivated in cancer. Canonically, Akt is activated by phosphoinositide-dependent kinase 1 and mechanistic target of rapamycin complex 2, which phosphorylate...
Articles
Biochem Soc Trans (2018) 46 (6): 1707–1712.
Published: 22 November 2018
...Suzanne R. Pfeffer Leucine-rich repeat kinase 2 (LRRK2) is mutated in familial Parkinson's disease, and pathogenic mutations activate the kinase activity. A tour de force screen by Mann and Alessi and co-workers identified a subset of Rab GTPases as bona fide LRRK2 substrates. Rab GTPases...
Articles
Biochem Soc Trans (2017) 45 (1): 65–77.
Published: 15 February 2017
...Akanksha Baharani; Brett Trost; Anthony Kusalik; Scott Napper There is increasing appreciation among researchers and clinicians of the value of investigating biology and pathobiology at the level of cellular kinase (kinome) activity. Kinome analysis provides valuable opportunity to gain insights...
Articles
Biochem Soc Trans (2016) 44 (6): 1603–1610.
Published: 02 December 2016
...Mark R. Cookson Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, associated with Parkinson's disease, have been shown to affect intracellular trafficking pathways in a variety of cells and organisms. An emerging theme is that LRRK2 can bind to multiple membranous structures in cells...
Articles
Biochem Soc Trans (2014) 42 (6): 1773–1779.
Published: 17 November 2014
...Lubna Freihat; Victor Muleya; David T. Manallack; Janet I. Wheeler; Helen R. Irving Over 30 receptor-like kinases contain a guanylate cyclase (GC) catalytic centre embedded within the C-terminal region of their kinase domain in the model plant Arabidopsis . A number of the kinase GCs contain both...
Articles
Biochem Soc Trans (2013) 41 (4): 1078–1082.
Published: 18 July 2013
...Hua Zhang; Chuay Yeng Koo; Justin Stebbing; Georgios Giamas Protein kinases play a pivotal role in regulating many aspects of biological processes, including development, differentiation and cell death. Within the kinome, 48 kinases (~10%) are classified as pseudokinases owing to the fact...
Articles
Biochem Soc Trans (2013) 41 (4): 1083–1088.
Published: 18 July 2013
...Jeroen Claus; Angus J.M. Cameron; Peter J. Parker Pseudokinases, the catalytically impaired component of the kinome, have recently been found to share more properties with active kinases than previously thought. In many pseudokinases, ATP binding and even some activity is preserved, highlighting...
Articles
Biochem Soc Trans (2012) 40 (5): 1074–1079.
Published: 19 September 2012
...Yulan Xiong; Valina L. Dawson; Ted M. Dawson Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene are the most frequent genetic cause of PD (Parkinson's disease), and these mutations play important roles in sporadic PD. The LRRK2 protein contains GTPase and kinase domains and several protein...
Articles
Biochem Soc Trans (2012) 40 (1): 257–261.
Published: 19 January 2012
... functions of prominent members of the group, such as PtdIns(3,4,5) P 3 , the product of the critically important Class I PI3Ks (phosphoinositide 3-kinases), are understood in detail. In contrast, much less is known about other phosphoinositides. In particular, the monophosphorylated phosphoinositide...
Articles
Biochem Soc Trans (2012) 40 (1): 67–72.
Published: 19 January 2012
... cues. This has been particularly elucidated for the Ras/Raf/MEK [mitogen-activated growth factor/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling pathway with a number of studies in fibroblasts showing that sustained ERK signalling is a requirement for S-phase entry, whereas transient...
Articles
Biochem Soc Trans (2010) 38 (4): 1012–1015.
Published: 26 July 2010
... in interactions with actin BMC Cell Biol. 2009 10 81 9 Lee G. Newman S.T. Gard D.L. Band H. Panchamoorthy G. Tau interacts with src-family non-receptor tyrosine kinases J. Cell Sci. 1998 111 3167 3177 10 Reynolds C.H. Garwood C.J. Wray S. Price C...
Articles
Biochem Soc Trans (2010) 38 (4): 928–933.
Published: 26 July 2010
.... Despite the obvious and significant differences between these quite different physicochemical stimuli, the result is the same: the stressosome is phosphorylated by a key kinase to initiate the σ B cascade. The phosphorylation of the stressosome initiates a signal transduction system that up-regulates...
Articles
Biochem Soc Trans (2009) 37 (5): 971–975.
Published: 21 September 2009
...Geert J.P.L. Kops Error-free chromosome segregation during cell division relies on chromosome biorientation and mitotic checkpoint activity. A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles...
Articles
Biochem Soc Trans (2009) 37 (1): 29–35.
Published: 20 January 2009
... these two domains. We are studying a complex of two proteins conserved in Archaea and Eukarya whose precise biological role and biochemical function remain unknown. One of them is a universal protein known as Kae1 (kinase-asociated endopeptidase 1). The second protein is a serine/threonine kinase...
Articles
Biochem Soc Trans (2008) 36 (3): 411–415.
Published: 21 May 2008
... and cytokinesis. SIN signalling requires three protein kinases for its function and is mediated by a ras-superfamily GTPase. We discuss the elements of the SIN and how they are regulated. 1 Correspondence may be addressed to either of these authors (email andrea.krapp@epfl.ch or viesturs.simanis@epfl.ch...
Articles
Biochem Soc Trans (2005) 33 (2): 343–345.
Published: 01 April 2005
...A.J. Bridges The development of kinase and phosphatase inhibitors as novel therapeutic agents has been stimulated by the discovery that most biological processes are controlled by the reversible phosphorylation of proteins. Most of the early results in this area were generated in oncology...
Articles
Biochem Soc Trans (2005) 33 (2): 354–357.
Published: 01 April 2005
... (email Juleen.Zierath@fyfa.ki.se ). 1 11 2004 © 2005 The Biochemical Society 2005 glucose uptake insulin insulin resistance kinase signal transduction skeletal muscle Type II diabetes At least 12 substrates of the insulin receptor have been identified so far: IRS-1...
Articles
Biochem Soc Trans (2003) 31 (4): 857–860.
Published: 01 August 2003
... is to elucidate the mechanisms regulating clathrin-mediated trafficking. One of the fundamental processes governing the complicated network of interactions is phosphorylation. It has been known for some time that several proteins associated with clathrin-coated vesicles are substrates for protein kinases...