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Keywords: isoform selectivity
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Biochem Soc Trans (2007) 35 (2): 253–256.
Published: 20 March 2007
... PI3K isoform selectivity in order to minimize safety risks, it is not yet certain that this approach will deliver suitable benefit against disease when tested in the clinic. The UCB strategy, therefore, has been to generate a range of compounds covering a broad spectrum of PI3K isoform inhibition...