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Keywords: ischaemia
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Articles
Biochem Soc Trans (2015) 43 (3): 513–518.
Published: 01 June 2015
... potential cardiac myocyte: fibroblast coupling connexin fibrosis gap junction ischaemia The trigger for cardiac contraction begins in the sinoatrial node (SAN), where electrical impulses are transmitted through the atria causing them to contract. Signals are delayed at the atrioventricular node...
Articles
Biochem Soc Trans (2014) 42 (6): 1629–1636.
Published: 17 November 2014
... The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis ischaemia microRNA (miRNA) stem cell vascular cell miRNAs are a family of short (20–26 nt) evolutionary conserved non-coding ssRNAs that are known to regulate or silence gene expression by repressing protein...
Articles
Biochem Soc Trans (2013) 41 (5): 1325–1330.
Published: 23 September 2013
... temperatures. Such deactivation occurs in vitro in the absence of substrates or in vivo during ischaemia, when the ubiquinone pool is reduced. The D-form can undergo reactivation given both NADH and ubiquinone availability during slow ( k ~1–10 min −1 ) catalytic turnover(s). We examined known conformational...
Articles
Biochem Soc Trans (2010) 38 (2): 460–465.
Published: 22 March 2010
... 2010 α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) endosome ischaemia plasticity protein that interacts with protein C-kinase 1 (PICK1) trafficking AMPARs [AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors] mediate most of the fast excitatory synaptic...
Articles
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
...Seppo Ylä-Herttuala Therapeutic angiogenesis is a promising new concept for the treatment of myocardial and peripheral ischaemia. Members of the VEGF (vascular endothelial growth factor) family are among the most powerful modulators of angiogenesis. They regulate vascular growth and maintenance...
Articles
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
... and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures. 1 email dnicholls@buckinstitute.org 4 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 ATP excitotoxicity glutamate ischaemia mitochondrion...
Articles
Biochem Soc Trans (2009) 37 (6): 1218–1220.
Published: 19 November 2009
... should be addressed (email p.riley@ich.ucl.ac.uk ). 1 5 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cardiovascular regenerative medicine epicardium ischaemia neovascularization regeneration thymosin β4 The key signalling molecules and cell...
Articles
Biochem Soc Trans (2007) 35 (5): 1052–1054.
Published: 25 October 2007
... death pathways induced by cardiac ischaemia/reperfusion injury. PKC (protein kinase C) ϵ plays a critical role in cardioprotective signalling pathways that protect the heart from ischaemia/reperfusion. Emerging evidence suggests that the cardioprotective target of PKCϵ resides at the mitochondria...
Articles
Biochem Soc Trans (2007) 35 (5): 1122–1126.
Published: 25 October 2007
... 2007 inflammation interleukin-1 (IL-1) interleukin-1 receptor antagonist (IL-1RA) ischaemia neurodegenerative disease stroke Inflammation is generally a beneficial response of an organism to infection but, when prolonged or inappropriate, it can be detrimental. Neuronal loss in acute...
Articles
Biochem Soc Trans (2007) 35 (5): 1142–1146.
Published: 25 October 2007
... 2007 Biochemical Society 2007 carbon monoxide-releasing molecule (CO-RM) guanylate cyclase haem oxygenase inflammation ischaemia vasodilatation Figure 1 Chemical structure of lipid-soluble and water-soluble CORMs The chemical structures of lipid-soluble (CORM-1 and CORM-2...
Articles
Biochem Soc Trans (2007) 35 (2): 204–206.
Published: 20 March 2007
... be addressed (email jdoukas@targegen.com ). 30 10 2006 © 2007 The Biochemical Society 2007 inflammation ischaemia myocardial infarction oedema phosphoinositide 3-kinase (PI3K) MI (myocardial infarction) represents the heart's attempt to manage an I/R (ischaemia/reperfusion) injury...
Articles
Biochem Soc Trans (2006) 34 (6): 1295–1298.
Published: 25 October 2006
... during acute brain ischaemia is multifactorial and complex [ 1 ]. Efforts to accurately model this process are hampered by the sheer number of participating molecular mechanisms and by their intricate interplay. For example, a list of general pathobiological mechanisms in acute brain ischaemia (each...
Articles
Biochem Soc Trans (2006) 34 (6): 1307–1309.
Published: 25 October 2006
... of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 711, Baltimore, MD 21205, U.S.A. (email vdawson@jhmi.edu ). 22 7 2006 © 2006 The Biochemical Society 2006 brain excitotoxicity ischaemia preconditioning stroke To begin to uncover...
Articles
Biochem Soc Trans (2006) 34 (6): 1267–1270.
Published: 25 October 2006
... increases after focal ischaemia in the rat, particularly in reactive astrocytes and microglia cells [ 29 , 31 ], indicating that JAK/STAT is an important mediator of inflammatory responses in brain ischaemia. A strong increase in the expression of STAT3 [ 29 ] and STAT1 [ 30 ] occurs in reactive microglia...
Articles
Biochem Soc Trans (2006) 34 (2): 232–237.
Published: 20 March 2006
... cell death of the heart and brain that occurs during reperfusion after a long period of ischaemia. Such reperfusion injury is a major problem during cardiac surgery and in the treatment of coronary thrombosis and stroke. Prevention of MPTP opening either directly, using agents such as cyclosporin...
Articles
Biochem Soc Trans (2000) 28 (2): 164–169.
Published: 01 February 2000
... membranes can be detected in saponin-skinned fibres with spectrophotometric and oxygraphic methods. This is of special interest in respect to acute impairment of mitochondria during ischaemia/reperfusion. 6 8 1999 © 2000 Biochemical Society 2000 OM, outer membrane IMS, intermembrane space...