... homodimers and their topology suggests they function as exporters. The results of mutant studies point towards involvement in iron cofactor biosynthesis. In particular, ABC subfamily B member 7 (ABCB7) and its homologues in yeast and plants are required for iron-sulfur (Fe-S) cluster biosynthesis outside...

...Vishant Mahendra Boradia; Manoj Raje; Chaaya Iyengar Raje Iron is essential for the survival of both prokaryotic and eukaryotic organisms. It functions as a cofactor for several vital enzymes and iron deprivation is fatal to cells. However, at the same time, excess amounts of iron are also toxic...

...Michaela C. Hohnholt; Ralf Dringen Astrocytes are considered key regulators of the iron metabolism of the brain. These cells are able to rapidly accumulate iron ions and various iron-containing compounds, store iron efficiently in ferritin and also export iron. The present short review summarizes...

... possibly be defined in relation to the binding of cofactors. It has been suggested recently that α-synuclein is able to reduce iron using copper as its catalytic centre. The consequence of this is that possibly the function of α-synuclein can now be defined. The evidence for this and the consequences...

...Eric E. Roden In addition to its central role in mediating electron-transfer reactions within all living cells, iron undergoes extracellular redox transformations linked to microbial energy generation through utilization of Fe(II) as a source of chemical energy or Fe(III) as an electron acceptor...

...Magali Roger; Cindy Castelle; Marianne Guiral; Pascale Infossi; Elisabeth Lojou; Marie-Thérèse Giudici-Orticoni; Marianne Ilbert Acidithiobacillus ferrooxidans is an acidophilic chemolithoautotrophic Gram-negative bacterium that can derive energy from the oxidation of ferrous iron at pH 2 using...

...Gracia Becerra; Rafael Blasco; Alberto Quesada; Faustino Merchán; M. Isabel Igeño Pseudomonas pseudoalcaligenes CECT5344 can be used in cyanide bioremediation processes because it grows at pH 9.5 using 2.0 mM cyanide at the sole nitrogen source. Cyanide strongly binds to metals creating iron...

... normal circumstances. In developed countries, this applies mainly to micronutrients. Even now, iron deficiency is a common disorder, especially in pregnancy. Similarly, copper intake in the U.K. population is rarely above adequate levels. It is now becoming clear that nutrient deficiencies during...

... site of sMMO is a carboxylate-bridged di-iron centre and the catalytic cycle has been studied extensively [ 6 ]. In contrast, the active site of pMMO remains unidentified, with significant controversy pervading the field over the last decade [ 7 , 8 ]. In the present review, the evolution of current...

...Jack T. Rogers; Ashley I. Bush; Hyan-Hee Cho; Deborah H. Smith; Andrew M. Thomson; Avi L. Friedlich; Debomoy K. Lahiri; Peter J. Leedman; Xudong Huang; Catherine M. Cahill The essential metals iron, zinc and copper deposit near the Aβ (amyloid β-peptide) plaques in the brain cortex of AD...

...Michael K. Georgieff Iron is a ubiquitous nutrient that is necessary for normal neurodevelopment. Gestational conditions that compromise fetal iron status include maternal iron deficiency, smoking, diabetes mellitus and hypertension. The iron-deficient neonate has altered recognition memory...

...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...

... (EGF β-hydroxylase) and putative asparagine/asparaginyl hydroxylases. Sequence analyses imply that EGFH does not contain the HXD/E iron-binding motif characteristic of most of the 2-oxoglutarate oxygenases. Genes: Regulation, Processing and Interference: A Focus Topic at BioScience2004, held...

...H. Oberegger; I. Zadra; M. Schoeser; B. Abt; W. Parson; H. Haas Iron is an essential trace element for almost all organisms. However, an excess of this metal within cells can be deleterious on account of catalysis of cell-damaging hydroxyl radicals. Therefore, the concentration of iron within cells...

..., overload of some trace elements, including copper and iron, has been demonstrated to result in adverse effects. However, under normal physiological conditions, such overloads are unlikely to occur. 1 e-mail: jm.oconnor@ulstac.uk 8 11 2000 © 2001 Biochemical Society 2001...