...Yasushi Okamura; Daisuke Yoshioka Many membrane proteins including ion channels and ion transporters are regulated by membrane phospholipids such as phosphoinositides in cell membranes and organelles. Voltage-sensing phosphatase, VSP, is a voltage-sensitive phosphoinositide phosphatase which...

...]. The structural basis of CF will be discussed in this article. cystic fibrosis transmembrane conductance regulator ion channel protein structure transmembrane proteins Initial structural studies were carried out over a decade ago on the soluble CFTR domains studied in isolation from...

...Antony J. Palmer; Alison Baker; Stephen P. Muench The ALMT (aluminium-activated malate transporter) family comprises a functionally diverse but structurally similar group of ion channels. They are found ubiquitously in plant species, expressed throughout different tissues, and located in either...

... polyphosphate ion channel metabolism sol–gel transition transcription regulation PolyP is particularly abundant in bacteria and yeast, where it is present in the millimolar range and comprises long polymers that can reach hundreds of phosphates in length. By contrast, in mammalian organisms, polyP...

... is deleted. bacteriocin drug export ion channel outer membrane protein receptor An understanding of the molecular mechanism of colicin import would contribute not only to elucidation of the biochemical and biophysical events that are unique to the mechanism of colicin cytotoxicity [ 1 – 9...

... compilation © 2012 Biochemical Society 2012 calcium signalling endoplasmic reticulum ion channel Orai store-operated calcium entry (SOCE) stromal interaction molecule (STIM) Cytosolic Ca 2+ elevations control a large array of cellular functions, notably the contraction of cardiac...

... regions of the GluN2D subunit. Our results show that the identity of the GluN2 LBD not only controls glutamate potency, but also influences the potency of the NMDAR co-agonist glycine, whereas the single-channel conductance and the duration of single activations of ion channels can be predicted...

... The Authors Journal compilation © 2009 Biochemical Society 2009 ion channel neural blockade neuroplasticity noradrenaline pain surgery Currently, treatment of CPSP is determined by the nature of the presenting symptoms and signs. A presentation of neuropathic pain is generally limited...

... to a fetal gene-expression profile in cardiac myocytes results in cardiac hypertrophy and changes in the expression of many ion channel genes leads to a phenotypic switch from contractile to proliferative smooth muscle cells in vascular diseases such as neointimal hyperplasia and atherosclerosis...

... fibrillation. Mutations in a number of genes that encode ion channels have been implicated in LQTS. Hereditary mutations in the α- and β-subunits, KCNQ1 and KCNE1 respectively, of the K + channel pore I Ks are the commonest cause of LQTS and account for LQTS types 1 and 5 respectively (LQT1 and LQT5). Recently...

...S.M. Mizielinska Neuronal excitability is determined by the flux of ions through ion channels. Many types of ion channels are expressed in the central nervous system, each responsible for its own aspect of neuronal excitability, from postsynaptic depolarization to action potential generation...

....) and S. Ward (Bath, U.K.). 1 To whom correspondence should be addressed (email a.mackenzie@bath.ac.uk ). 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 ATP ion channel NADPH oxidase P2X 7 phosphoinositide 3-kinase (PI3K) reactive nitrogen...

... correspondence should be addressed (email jtrimmer@ucdavis.edu ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 calcineurin electrical signalling ion channel mass spectrometry neuron protein kinase Protein phosphorylation constitutes one of the major...

... be addressed (email t.segal@ucl.ac.uk ). 12 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 chronic granulomatous disease (CGD) ion channel NADPH oxidase neutrophil oxidase phagocyte reactive oxygen species Phagocytosis by neutrophils is accompanied...

...J.A. Peters; J.E. Carland; M.A. Cooper; M.R. Livesey; T.Z. Deeb; T.G. Hales; J.J. Lambert Nicotinic ACh (acetylcholine) and 5-HT 3 (5-hydroxytryptamine type-3) receptors are cation-selective ion channels of the Cys-loop transmitter-gated ion channel superfamily. Numerous lines of evidence indicate...

...K. Krzywkowski 5-HT 3 receptors are members of the Cys-loop superfamily of ligand-gated ion channels. In both the central and the peripheral nervous systems, 5-HT 3 receptors excite postsynaptic cells and modulate the release of neurotransmitters from presynaptic neurons. 5-HT 3 receptors are known...

..., the activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG ( h uman e ther-a-go-go- r elated g ene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the β1 integrin subunit. This activation is apparently a determining...

... Focused Meeting held at University of Liverpool, 1–2 May 2003 1 May 2003 © 2003 Biochemical Society 2003 Ca 2+ channel Ca 2+ spark Fura-2 ion channel ryanodine receptor sarcoplasmic reticulum Abbreviations used: [Ca 2+ ] i , intracellular calcium concentration; STOC...

...R.A.J. McIlhinney; E. Philipps; B. Le Bourdelles; S. Grimwood; K. Wafford; S. Sandhu; P. Whiting The N -methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different...

...A. Clark; S. Howell 1 To whom correspondence should be addressed(e-mail a.clark@organon.co.uk ) 9 4 2002 © 2002 Biochemical Society 2002 high-throughput screening ion channel nuclear receptor HTS, high-throughput screening High-Throughput Screening: The Way...

... high-throughput screening ion channel nuclear receptor FRET, fluorescence resonance energy transfer VIPR, voltage/ion probe reader HTS, high-throughput screening Biochemical Society Transactions (2002) Volume 30, part 4 A flexible technology platform to explore valuable drug targets J. H...

... interact with membranes and thereby attain their folded structure. An approach that we have been exploring involves dissecting voltage-gated ion channels into simple peptide domains for the purpose of determining their structure in different media using physical techniques. We have synthesized peptides...

.... Introduction Toxic metal pollution, which is due mainly to burning fossil fuels, to manufactured waste and to the indiscriminate use of chemicals, has ac- celerated markedly in recent years owing to world Key words: ion channel, Pb toxicity, signal transduction. Abbreviations used: CNG, cyclic-nucleotide-gated...