... of these proteoglycans are mediated by their interactions with 347 protein partners [ 3 ]. 19 2 2023 3 6 2023 7 6 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 co-receptors interaction networks intrinsically disordered proteins...

...(s) 2023 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . intrinsically disordered proteins molecular scaffolds structural biology transcription...

... use of HDX-MS, and how it can be generally applied to the study of intrinsically disordered proteins. Hydrogen-deuterium exchange is a well-established technique that has its historical basis beginning over 70 years ago with the pioneering work of Linderstrøm-Lang [ 20 ]. The technique has...

.... There is solid evidence for the importance of IDRs in interacting with the rigid catalytic core of PP1 and PP2A: For PP1, it has been demonstrated that more than 70% of its regulatory proteins constitute intrinsically disordered proteins (IDPs). For example, the complex of PP1 with its myosin-targeting subunit...

...Nike Heinß; Mikhail Sushkin; Miao Yu; Edward A. Lemke Nucleoporins (Nups) represent a range of proteins most known for composing the macromolecular assembly of the nuclear pore complex (NPC). Among them, the family of intrinsically disordered proteins (IDPs) phenylalanine-glycine (FG) rich Nups...

... under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . context-dependence fuzzy complexes fuzzy logic intrinsically disordered proteins protein–protein interactions Traditionally, we consider a statement either true or false (0 or 1, Boolean logic). In our everyday life...

... BY) . Open access for this article was enabled by the participation of University of Cambridge in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. intracellular signaling intrinsically disordered proteins membrane...

... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 CRIB effectors intrinsically disordered proteins protein conformation small G-proteins The field of small G-protein biology, as much as any other, has been dominated and beautifully informed...

... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 co-translational interactions intrinsically disordered proteins multiprotein complexes protein–protein interaction quality control surveillance A common theme for complex...

... compounds that target intrinsically disordered proteins (IDPs) such as Myc directly is a daunting challenge due to the absence of stable and well-defined pockets that could be probed with small molecules [ 5 , 6 ]. Because of these difficulties, many attempts have been made to inhibit Myc indirectly...

... of association and disassociation rates depending on the mode of interaction (e.g. conformational selection versus induced folding) [ 65 , 80 , 82 – 84 ]. For a given K d value, the kinetic constants can vary widely [ 81 ]. Several different intrinsically disordered proteins (IDPs; proteins with IDRs) have...

...Mi-Kyung Yoon; Diana M. Mitrea; Li Ou; Richard W. Kriwacki Today, it is widely accepted that proteins that lack highly defined globular three-dimensional structures, termed IDPs (intrinsically disordered proteins), play key roles in myriad biological processes. Our understanding of how intrinsic...