...Mustafa Yassin Taher; David Marc Davies; John Maher Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may ‘trans-signal’ in a manner that is facilitated by its binding to a soluble...

... neuronal networks with newly born neurons in the chronic phase of cerebral ischaemia). In this paper, we review our recent progress in development of these distinct new strategies for treatment of damaged brain following a stroke. Firstly, we investigated the role of endogenous IL-6 (interleukin-6), which...

... ). 26 7 2005 © 2005 The Biochemical Society 2005 cAMP cytokine receptor endothelial cell (EC) interleukin-6 phosphorylation signal transducer and activator of transcription (STAT) This work is supported by the British Heart Foundation, Heart Research U.K. and the Biotechnology...

... in the obese state. Protein production is, as a metabolic activity, subject to regional variations. In particular, the production of leptin, angiotensinogen, interleukin-6 and plasmin activator inhibitor-1 differs between subcutaneous and visceral adipose tissue sites, but no regional differences have been...