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Keywords: integrins
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Articles
Biochem Soc Trans (2020) 48 (3): 1187–1198.
Published: 15 May 2020
... from other proteins and signaling routes. For instance, Wnt/β-catenin signaling involves YAP and TAZ, which are transcription factors with crucial roles in mechanotransduction. On the other hand, Wnt/β-catenin signaling is also modulated by integrins. Therefore, mechanical signals might similarly...
Articles
Biochem Soc Trans (2020) 48 (1): 83–93.
Published: 17 February 2020
...Giulia Mana; Donatella Valdembri; Guido Serini Spatiotemporal control of integrin-mediated cell adhesion to the extracellular matrix (ECM) is critical for physiological and pathological events in multicellular organisms, such as embryonic development, angiogenesis, platelet aggregation, leukocytes...
Articles
Biochem Soc Trans (2016) 44 (5): 1465–1473.
Published: 19 October 2016
... cellular environments. The extracellular matrix contains information regarding tissue architecture and its mechanical properties that is transmitted to the cell via integrin receptors. In this review, I describe various examples of modulation of the BMP pathway by integrins. In the case of the Drosophila...
Articles
Biochem Soc Trans (2016) 44 (5): 1549–1560.
Published: 19 October 2016
... melanogaster heart failure integrins mechanical forces mechanotransduction Heart disease is a major cause of mortality in modern society [ 1 , 2 ]. Chronic heart failure (HF) represents 8% of the disease population [ 3 ], and more than 70% of which had a history of arterial hypertension and 25...
Articles
Biochem Soc Trans (2016) 44 (2): 377–385.
Published: 11 April 2016
..., integrins and chemokine receptors on T-cells by their respective ligands which are up-regulated on inflamed blood vessels. Clinical data and experimental studies in mice suggest that tumour blood vessels are anergic to inflammatory stimuli and the recruitment of cytotoxic CD8 + T-lymphocytes is not very...
Articles
Biochem Soc Trans (2016) 44 (2): 349–355.
Published: 11 April 2016
... tumour-specific targets. The αvβ6 integrin is strongly up-regulated in multiple solid tumours including those derived from colon, lung, breast, cervix, ovaries/fallopian tube, pancreas and head and neck. It is associated with poorer prognosis in several cancers and exerts pro-tumorigenic activities...
Articles
Biochem Soc Trans (2002) 30 (2): 168–173.
Published: 01 April 2002
... in β 2 -integrin-mediated adhesion of leukocytes; uPAR also directly mediates leukocyte adhesion to vitronectin, a multifunctional adhesion protein that is associated with the extracellular matrix. The latter process is inhibited by plasminogen activator inhibitor-1. Both β 2 -integrin- and uPAR...
Articles
Biochem Soc Trans (2000) 28 (4): 311–340.
Published: 01 August 2000
...M.J. Humphries The integrins are a family of α,β heterodimeric receptors that mediate dynamic linkages between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins are expressed by all multicellular animals, but their diversity varies widely among species...