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Keywords: insulin signalling
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Articles
Biochem Soc Trans (2019) 47 (2): 571–590.
Published: 01 April 2019
...Kiran Javed; Stephen J. Fairweather Amino acids are increasingly recognised as modulators of nutrient disposal, including their role in regulating blood glucose through interactions with insulin signalling. More recently, cellular membrane transporters of amino acids have been shown to form...
Articles
Biochem Soc Trans (2007) 35 (2): 257–259.
Published: 20 March 2007
... enzyme in insulin signalling regulating glucose uptake and cell growth. Therefore PTEN has recently moved into the spotlight as a drug target in diabetes. This review summarizes studies undertaken on PTEN's role in glucose uptake, insulin resistance, diabetes and its controversial role in GLUT (glucose...
Articles
Biochem Soc Trans (2005) 33 (2): 358–361.
Published: 01 April 2005
... insulin signalling, however, are not completely understood and remain somewhat controversial. In the present review, we summarize our studies attempting to explore the molecular mechanisms underlying the effects of insulin sensitizers in cells and in animal models of insulin resistance. In 3T3-L1...
Articles
Biochem Soc Trans (2004) 32 (5): 817–821.
Published: 26 October 2004
...Q.L. Zhou; J.G. Park; Z.Y. Jiang; J.J. Holik; P. Mitra; S. Semiz; A. Guilherme; A.M. Powelka; X. Tang; J. Virbasius; M.P. Czech Using siRNA-mediated gene silencing in cultured adipocytes, we have dissected the insulin-signalling pathway leading to translocation of GLUT4 glucose transporters...
Articles
Biochem Soc Trans (2004) 32 (5): 812–816.
Published: 26 October 2004
... the insulin receptor from its downstream effectors and thereby terminate insulin signal transduction. This article focuses on the Ser/Thr protein kinases which phosphorylate insulin receptor substrates and the major Ser sites that are phosphorylated, as key elements in the uncoupling of insulin signalling...