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Keywords: insulin secretion
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Articles
Biochem Soc Trans (2019) 47 (6): 1843–1855.
Published: 07 November 2019
...Mauricio Di Fulvio; Lydia Aguilar-Bryan It is accepted that insulin-secreting β-cells release insulin in response to glucose even in the absence of functional ATP-sensitive K + (K ATP )-channels, which play a central role in a ‘consensus model’ of secretion broadly accepted and widely reproduced...
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Biochem Soc Trans (2019) 47 (2): 571–590.
Published: 01 April 2019
... a pivotal part of this regulation as they are primarily responsible for controlling cellular and circulating amino acid concentrations. The availability of amino acids regulated by transporters can amplify insulin secretion and modulate insulin signalling in various tissues. In addition, insulin itself can...
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Biochem Soc Trans (2018) 46 (3): 555–564.
Published: 17 April 2018
...Charles Affourtit; Ben Alberts; Jonathan Barlow; Jane E. Carré; Anthony G. Wynne The canonical model of glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells predicts a glucose-induced rise in the cytosolic ATP/ADP ratio. Such bioenergetic sensitivity to metabolic fuel is unusual...
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Biochem Soc Trans (2012) 40 (4): 800–803.
Published: 20 July 2012
...Jonathan M. Locke; Lorna W. Harries Recent studies in mouse, involving the β-cell-specific deletion of Dicer1, have highlighted the crucial role of miRNAs (microRNAs) in regulating insulin secretion and consequently Type 2 diabetes. Identifying the individual miRNAs involved in human islet...
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Biochem Soc Trans (2008) 36 (5): 916–919.
Published: 19 September 2008
... (email t.biden@garvan.org.au ). 21 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 glucose-stimulated insulin secretion insulin secretion lipotoxicity pancreatic β-cell protein kinase C (PKC) Type 2 diabetes The PKC (protein kinase C) family...
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Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
...P. Newsholme; K. Bender; A. Kiely; L. Brennan In addition to the primary stimulus of glucose, specific amino acids may acutely and chronically regulate insulin secretion from pancreatic β-cells in vivo and in vitro . Mitochondrial metabolism is crucial for the coupling of glucose, alanine...
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Biochem Soc Trans (2006) 34 (5): 824–827.
Published: 25 October 2006
... to this signal transduction mechanism, mitochondria integrate and generate metabolic signals, thereby coupling glucose recognition with insulin secretion. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic Ca 2+ , in the stimulation...
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Biochem Soc Trans (2006) 34 (5): 802–805.
Published: 25 October 2006
...C.B. Chan; N. Kashemsant UCPs (uncoupling proteins) can regulate cellular ATP production by uncoupling oxidative phosphorylation. UCP2 is expressed in islet β-cells and its induction reduces glucose-stimulated insulin secretion. Under physiological conditions, superoxide, formed as a by-product...
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Biochem Soc Trans (2006) 34 (5): 675–678.
Published: 25 October 2006
...-cell level. Changes in these parameters, including the premature termination of single exocytotic events, are demonstrated as a possible contributor to the overall deficiency in insulin secretion observed in Type 2 diabetes [ 19 ]. Are there changes in the nature of release events...
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Biochem Soc Trans (2006) 34 (2): 243–246.
Published: 20 March 2006
...-cells is normal, glucose fails to close pancreatic β-cell K ATP channels or to elevate intracellular calcium and stimulate insulin secretion. This suggests a defect in glucose metabolism. Genetic mapping identified a loss-of-function mutation in the gene encoding Nnt (nicotinamide nucleotide...
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Biochem Soc Trans (2003) 31 (6): 1115–1119.
Published: 01 December 2003
... glucose and fatty acids interact. These include stimulation of hepatic glucose output by fatty acids, potentiation of glucose-stimulated insulin secretion by fatty acids, and the cellular mechanism whereby high glucose and insulin concentrations inhibit fatty acid oxidation via malonyl-CoA regulation...
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Biochem Soc Trans (2002) 30 (2): 323–327.
Published: 01 April 2002
...M. V. Mikhailov; E. A. Mikhailova; S. J. H. Ashcroft The ATP-sensitive potassium (K ATP ) channel plays a key role in controlling β-cell membrane potential and insulin secretion. The channels are composed of two subunits, Kir6.2, which forms the channel pore, and SUR1, which contains binding sites...