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Keywords: insulin resistance
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Articles
Biochem Soc Trans (2017) 45 (4): 979–985.
Published: 14 July 2017
...Anna M. Kirwan; Yvonne M. Lenighan; Marcella E. O'Reilly; Fiona C. McGillicuddy; Helen M. Roche Metabolic inflammation is a very topical area of research, wherein aberrations in metabolic and inflammatory pathways probably contribute to atherosclerosis, insulin resistance (IR) and type 2 diabetes...
Articles
Biochem Soc Trans (2016) 44 (2): 638–644.
Published: 11 April 2016
... disease (CVD) and non-alcoholic fatty liver disease, as well as the development of insulin resistance and obesity. 1 To whom correspondence should be addressed (email jules.griffin@mrc-hnr.cam.ac.uk ; jlg40@cam.ac.uk ). 15 1 2016 © 2016 Authors; published by Portland Press Limited...
Articles
Biochem Soc Trans (2015) 43 (5): 1108–1111.
Published: 09 October 2015
...Sabrina Prudente; Vincenzo Trischitta Insulin resistance is pathogenic for many prevalent disorders including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), polycystic ovary syndrome, non-alcoholic fatty liver disease, Alzheimer's and Parkinson's diseases and several cancers...
Articles
Biochem Soc Trans (2013) 41 (5): 1335–1341.
Published: 23 September 2013
... respectively, and they play particular roles in the essential Fe–S cluster biogenesis and in acetate metabolism. LYRM proteins have been implicated in mitochondrial dysfunction, e.g. in the context of insulin resistance. However, the functional significance of the common LYRM is still unknown. Analysis...
Articles
Biochem Soc Trans (2013) 41 (4): 896–901.
Published: 18 July 2013
... reveal that, in addition to persistent mTORC1 signalling, increased mTORC2 signals can promote insulin resistance due to mTORC2-mediated degradation of IRS-1. Our findings reveal that mTORC2 is important for controlling cellular insulin sensitivity via its novel role in feedback regulation of IRS-1...
Articles
Biochem Soc Trans (2011) 39 (6): 1752–1757.
Published: 21 November 2011
... of Dunnigan and metabolic laminopathies, are characterized by lipodystrophic syndromes with altered fat distribution and severe metabolic alterations with insulin resistance and dyslipidaemia. Metabolic disturbances could be due either to the inability of adipose tissue to adequately store triacylglycerols...
Articles
Biochem Soc Trans (2010) 38 (6): 1565–1570.
Published: 24 November 2010
...David Ferland-McCollough; Susan E. Ozanne; Kenneth Siddle; Anne E. Willis; Martin Bushell T2D (Type 2 diabetes mellitus) is a major health issue that has reached epidemic status worldwide. T2D is a progressive metabolic disorder characterized by reduced insulin sensitivity, insulin resistance...
Articles
Biochem Soc Trans (2009) 37 (5): 981–985.
Published: 21 September 2009
..., from the plasma membrane to the interior of the cell, resulting in cellular insulin resistance that can be overcome by increasing the levels of SNAP-23. The same missorting of SNAP-23 occurs in vivo in skeletal-muscle biopsies from patients with T2D (Type 2 diabetes). Moreover, there was a linear...
Articles
Biochem Soc Trans (2008) 36 (5): 935–940.
Published: 19 September 2008
... in organ–tissue dysfunction and the metabolic syndrome. While these mechanisms explain the contribution of various circulating factors in the development of insulin resistance, all require the presence of dysfunctional adipose depots. This raises a number of questions. (i) Why/how adipocytes become...
Articles
Biochem Soc Trans (2007) 35 (5): 1175–1179.
Published: 25 October 2007
... (email jbrosnan@mun.ca ). 11 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 betaine cystathionine β-synthase diabetes insulin resistance liver trans-sulfuration Since the observation, by McCully [ 1 ], of severe arteriosclerotic lesions...
Articles
Biochem Soc Trans (2007) 35 (5): 1295–1297.
Published: 25 October 2007
...B.K. Pedersen Low-grade chronic inflammation is a feature of Type 2 diabetes and appears to play a pathogenetic role in insulin resistance. It is well known that cytokines, besides their immunoregulatory roles, are important players in metabolism. Moreover, it has become evident that skeletal...
Articles
Biochem Soc Trans (2007) 35 (3): 477–481.
Published: 22 May 2007
...R. Mangat; J. Su; P.G. Scott; J.C. Russell; D.F. Vine; S.D. Proctor Postprandial (PP) lipaemia is a significant contributor to the development of dyslipidaemia and cardiovascular disease (CVD). It is also evident that PP lipaemia is prevalent during conditions of obesity and insulin resistance (IR...
Articles
Biochem Soc Trans (2007) 35 (1): 33–36.
Published: 22 January 2007
..., multigenic forms of the disease. Ultimately, this is a potential route to treatment of both disease types. This approach is discussed in relation to Type 2 diabetes, arising from both insufficient insulin production and insulin resistance. 1 email so104@medschl.cam.ac.uk 31 8 2006 ©...
Articles
Biochem Soc Trans (2005) 33 (5): 1053–1058.
Published: 26 October 2005
..., mutations in PPAR-γ that cause severe insulin resistance in humans when expressed in mice do not result in insulin insensitivity. However, these murine models can recapitulate the effects in fuel partitioning, post-prandial lipid handling and vasculature dysfunction observed in humans. In summary...
Articles
Biochem Soc Trans (2005) 33 (5): 1045–1048.
Published: 26 October 2005
...F. Karpe; G.D. Tan Insulin resistance is often seen as a consequence of obesity and there are several possible links between adipose tissue function and insulin resistance determined in other organs such as skeletal muscle or liver. One such link is the regulation of NEFA (non-esterified fatty acid...
Articles
Biochem Soc Trans (2005) 33 (2): 354–357.
Published: 01 April 2005
..., defects in this tissue play a major role in the impaired glucose homoeostasis in Type II diabetic patients. Thus identifying defective steps in this process may reveal attractive targets for drug development to combat insulin resistance and Type II diabetes. This review will describe the effects...
Articles
Biochem Soc Trans (2005) 33 (2): 339–342.
Published: 01 April 2005
...M.P. Coghlan; D.M. Smith Insulin regulates whole-body glucose homoeostasis by modulating the activities of protein kinases in its target tissues: muscle, liver and fat. Defects in insulin's ability to modulate protein kinase activity lead to ‘insulin resistance’ or impaired insulin action. Insulin...
Articles
Biochem Soc Trans (2004) 32 (6): 999–1002.
Published: 26 October 2004
...-sensitive transcription factors. This explains the molecular basis of some of the health effects associated with altered dietary fatty acid composition. The metabolic syndrome is a very common condition, characterized by insulin resistance, abdominal obesity, dyslipidaemia and hypertension. It often...
Articles
Biochem Soc Trans (2004) 32 (5): 812–816.
Published: 26 October 2004
...Y. Zick Insulin resistance refers to a decreased capacity of circulating insulin to regulate nutrient metabolism. Recent studies reveal that agents that induce insulin resistance exploit phosphorylation-based negative feedback control mechanisms otherwise utilized by insulin itself to uncouple...
Articles
Biochem Soc Trans (2004) 32 (1): 83–85.
Published: 01 February 2004
... diabetes, alterations in cardiac LCFA uptake precede alterations in cardiac glucose uptake. In obesity, in which insulin resistance is the key metabolic defect, cardiovascular diseases are the most serious com- plication [1]. In the obese heart , TAG (triacylglycerol) accumulation occurs rapidly...
Articles
Biochem Soc Trans (2003) 31 (6): 1115–1119.
Published: 01 December 2003
... acid) concentrations. (Indeed, all too often the term Randle cycle is used to refer Key words: glucose utilization, hepatic glucose output, insulin resistance, insulin secretion, non- esterified fatty acid, tissue triacylglycerol. Abbreviations used: ACC, acetyl-CoA carboxylase; CPT-1, carnitine...
Articles
Biochem Soc Trans (2003) 31 (6): 1120–1124.
Published: 01 December 2003
... tolerance tests suggest that HSL-null mice are insulin resistant. Liver, adipose tissue and skeletal muscle appear all to be sites of impaired insulin sensitivity in HSL-null mice. 1 e-mail cecilia.holm@medkem.lu.se 679th Meeting of the Biochemical Society held at the University of Essex...
Articles
Biochem Soc Trans (2003) 31 (1): 216–219.
Published: 01 February 2003
... insulin concentrations in the fed period and during the glucose tolerance test. Nevertheless, in isolated AMPKα2 −/− pancreatic islets, glucose-stimulated insulin secretion was not affected. Surprisingly, AMPKα2 −/− mice were insulin-resistant and had reduced muscle glycogen synthesis as assessed in vivo...
Articles
Biochem Soc Trans (2001) 29 (2): 227–230.
Published: 01 May 2001
...-activated receptor γ (PPARγ) regulates adipogenesis and mediates the action of thiazolidinediones - novel antidiabetic agents which enhance tissue insulin sensitivity. The PPARγ gene was screened in 85 subjects with severe insulin resistance, and two different heterozygous receptor mutations (P467L...