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Keywords: innate immunity
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Biochem Soc Trans (2024) 52 (1): 395–405.
Published: 13 February 2024
... to have many cellular roles, including in pre-mRNA splicing, innate immune sensing, ribosome biogenesis, translational regulation, and R-loop metabolism. In this review, we will summarize the latest understandings regarding the various roles of DDX41, as well as highlight challenges associated with drug...
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Biochem Soc Trans (2023) 51 (4): 1621–1633.
Published: 03 August 2023
... 2023 GTPases inflammasome innate immunity interferons trafficking virus replication The innate immune system is the primary line of defence against infection. In vertebrates, specialized pattern recognition receptors (PRRs) sense the pathogen associated molecular patterns (PAMPs...
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Biochem Soc Trans (2023) 51 (4): 1597–1610.
Published: 14 July 2023
...Chenge Liu; Cyrus Nikain; Yue-Ming Li Innate immunity is the first line of defense against pathogens, alerting the individual cell and surrounding area to respond to this potential invasion. γ-secretase is a transmembrane protease complex that plays an intricate role in nearly every stage...
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Coronavirus
Biochem Soc Trans (2023) 51 (3): 1047–1056.
Published: 18 May 2023
...Huy-Dung Hoang; Parisa Naeli; Tommy Alain; Seyed Mehdi Jafarnejad Interferons (IFNs) are crucial components of the cellular innate immune response to viral infections. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a remarkable capacity to suppress the host IFN...
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Biochem Soc Trans (2023) 51 (2): 539–555.
Published: 06 March 2023
... by the nucleic acid sensor cGAS, leading to the production of the second messenger 2′3′-cGAMP and activation of the critical hub of innate immune signalling STING. Activation of this immune pathway should instigate the influx and activation of immune cells, resulting in the eradication of cancer cells...
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Biochem Soc Trans (2023) 51 (1): 137–146.
Published: 06 January 2023
... of antiviral RNAi to immunity at the host level. Correspondence: Enzo Z. Poirier ( enzo.poirier@curie.fr ) 10 10 2022 12 12 2022 13 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 innate immunity RNA...
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Biochem Soc Trans (2022) 50 (5): 1341–1352.
Published: 25 October 2022
... into its recruitment, compartmentalisation and activation in cells of the innate immune system. In this review, we summarise the typical activation of ERK1/2 in growth factor receptor pathways before discussing its known roles in immune cell signalling with a focus downstream of TLRs. We examine emerging...
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Articles
Biochem Soc Trans (2021) 49 (6): 2601–2610.
Published: 02 December 2021
..., they are also highly expressed in other innate immune cells and IECs [ 8–10 ]. Upon ligand binding, NAIPs oligomerize with NLR family CARD-containing 4 (NLRC4) to form the NAIP/NLRC4 inflammasome. This is one of several canonical inflammasomes, which usually consist of caspase-1, the adaptor protein ASC...
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Biochem Soc Trans (2021) 49 (5): 2307–2317.
Published: 08 October 2021
.... Studies with the model animal C. elegans have uncovered a range of examples wherein innate immune responses are intimately connected with different homeostatic mechanisms, and can influence reproduction, ageing and neurodegeneration, as well as various other aspects of its biology. Here we provide a short...
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Biochem Soc Trans (2021) 49 (3): 1311–1324.
Published: 01 June 2021
...Georgia Bateman; Benjamin Hill; Ryan Knight; Dave Boucher Innate immune responses are tightly regulated by various pathways to control infections and maintain homeostasis. One of these pathways, the inflammasome pathway, activates a family of cysteine proteases called inflammatory caspases...
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Biochem Soc Trans (2020) 48 (6): 2823–2838.
Published: 06 November 2020
...Palamou Das; Oishee Chakrabarti Mitochondrial DNA (mtDNA) can initiate an innate immune response when mislocalized in a compartment other than the mitochondrial matrix. mtDNA plays significant roles in regulating mitochondrial dynamics as well as mitochondrial unfolded protein response (UPR...
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Articles
Biochem Soc Trans (2019) 47 (6): 1857–1866.
Published: 17 December 2019
... this classification. Correspondence: Kay Hofmann ( kay.hofmann@uni-koeln.de ) 29 10 2019 27 11 2019 28 11 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 host–pathogen interactions innate immunity Legionella protease...
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Biochem Soc Trans (2019) 47 (6): 1569–1579.
Published: 14 November 2019
...Mariano Prado Acosta; Bernd Lepenies Bacterial surfaces are rich in glycoconjugates that are mainly present in their outer layers and are of great importance for their interaction with the host innate immune system. The innate immune system is the first barrier against infection and recognizes...
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Articles
Biochem Soc Trans (2017) 45 (4): 929–935.
Published: 16 June 2017
... on behalf of the Biochemical Society 2017 endotoxin innate immunity myeloid cells TICAM-2 adaptor TLR4 Toll-like receptors (TLRs) are pattern recognition receptors which recognize pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs) [ 1 ]. TLRs are type I integral...
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Biochem Soc Trans (2015) 43 (5): 1116–1121.
Published: 09 October 2015
... of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte...
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Biochem Soc Trans (2015) 43 (4): 752–757.
Published: 03 August 2015
... activation. 1 To whom correspondence should be addressed (email i.torra@ucl.ac.uk ) . 12 5 2015 © 2015 Authors; published by Portland Press Limited 2015 adaptive immunity cholesterol gene regulation innate immunity lipid rafts liver X receptors (LXRs) LXR...
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Biochem Soc Trans (2014) 42 (4): 1159–1167.
Published: 11 August 2014
... as self RNA and to suppress activation of innate immune sensors that detect viral dsRNA. 1 Dedicated to the memory of Walter Gehring. 2 To whom correspondence should be addressed (email Liam.Keegan@igmm.ed.ac.uk ). 3 6 2014 © The Authors Journal compilation © 2014...
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Biochem Soc Trans (2014) 42 (1): 11–24.
Published: 23 January 2014
... the innate immune response by negatively regulating TLR signalling and/or promoting the secretion of anti-inflammatory cytokines. I present my discoveries on the key roles of the IKK (inhibitor of nuclear factor κB kinase)-related kinases and the SIKs (salt-inducible kinases) in limiting innate immunity...
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Biochem Soc Trans (2013) 41 (2): 687–693.
Published: 21 March 2013
... should be addressed (email d.g.hardie@dundee.ac.uk ). 7 12 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 AMP-activated protein kinase (AMPK) cancer inflammation innate immunity metabolism Figure 1 compares the typical pathways of metabolism...
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Biochem Soc Trans (2013) 41 (1): 252–257.
Published: 29 January 2013
... an energy-dependent mechanism, displaying differences in synthesis, size, function and composition [ 2 ]. exosome innate immunity microvesicle parasite–host cell interaction phosphatidylserine Extracellular vesicles were first reported many years ago [ 1 ]. In the subsequent decades...
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Biochem Soc Trans (2011) 39 (4): 989–993.
Published: 20 July 2011
... help in further elucidating the mechanism of LBP and its role in innate immunity and disease. 1 email ralf.schumann@charite.de 31 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 acute-phase protein endotoxin recognition innate immunity...
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Biochem Soc Trans (2011) 39 (4): 1057–1060.
Published: 20 July 2011
... acetylation, protein modification and microRNAs. adaptive immunity animal model gastrointestinal tract inflammatory bowel disease (IBD) innate immunity microflora pathogenicity The IBDs (inflammatory bowel diseases) are mainly represented by UC (ulcerative colitis) and Crohn's disease...
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Biochem Soc Trans (2011) 39 (4): 1012–1016.
Published: 20 July 2011
... with the innate immune defence molecules BPI (bactericidal/permeability-increasing protein) and LBP (lipopolysaccharide-binding protein), it has been difficult to define the functions of PLUNC. Based on its marked hydrophobicity and expression pattern, we hypothesized that PLUNC is an airway surfactant. We found...
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Biochem Soc Trans (2011) 39 (2): 669–673.
Published: 22 March 2011
...Aisling Dunne The recognition of pathogen-derived molecules by the innate immune system is mediated by a number of receptors, including members of the TLR (Toll-like receptor), RLH [RIG (retinoic acid-inducible gene)-like helicase] and the NLR (NOD-like receptor) families. NLRs in particular...
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Articles
Biochem Soc Trans (2008) 36 (6): 1461–1466.
Published: 19 November 2008
... of human MBL2 genetics. 1 email garred@post5.tele.dk 21 8 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 innate immunity mannose-binding lectin (MBL) mannan-binding lectin MBL1P1 opsonin pseudogene In recent years, there has been an emerging...
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Biochem Soc Trans (2008) 36 (6): 1457–1460.
Published: 19 November 2008
... applications of the knowledge gained. The review ends with speculations about future developments in lectin research and applications. 2 email nathan.sharon@weizmann.ac.il 12 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cancer carbohydrate innate immunity...
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Biochem Soc Trans (2008) 36 (6): 1487–1490.
Published: 19 November 2008
...Kazue Takahashi MBL (mannose-binding lectin) is a pattern recognition molecule and a component of innate immunity, the first line of the host defence system against foreign bodies and pathogens. MBL deficiency is common in humans and has been associated with immunodeficiency. We have generated...
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Biochem Soc Trans (2007) 35 (6): 1479–1484.
Published: 23 November 2007
... pathways in response to bacteria by inducing signalling pathways such as NF-κB (nuclear factor κB) and MAPKs (mitogen-activated protein kinases). The Nod proteins act independently of the TLR (Toll-like receptor) cascade, but potently synergize with the latter to trigger innate immune responses to microbes...
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Biochem Soc Trans (2007) 35 (6): 1445–1448.
Published: 23 November 2007
...R.I. Tapping; K.O. Omueti; C.M. Johnson Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense...
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Biochem Soc Trans (2006) 34 (2): 263–266.
Published: 20 March 2006
...C.L. Bevins Antimicrobial peptides are fundamental effector molecules of innate immunity, utilized in host defence by virtually all organisms studied. These gene-encoded peptides have direct antibiotic activity against a wide range of bacteria and other microbes. In humans and other mammals...
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Biochem Soc Trans (2006) 34 (2): 276–278.
Published: 20 March 2006
...P.S. Hiemstra Innate immunity provides an effective first line of defence against infections. This is of particular importance in the lung, an organ that is exposed to a large number of pathogens that are inhaled. Antimicrobial peptides play an important role in the defence against these pathogens...
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Biochem Soc Trans (2006) 34 (2): 267–269.
Published: 20 March 2006
... protein) AWAP IV innate immunity whey acidic protein domain (WAP domain) The innate immune system of higher eukaryotes provides the first line of defence against pathogenic invasion of the host, and includes the synthesis of small (1–10 kDa), structurally diverse AMPs (antimicrobial peptides...
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Biochem Soc Trans (2003) 31 (4): 801–805.
Published: 01 August 2003
...) and long (l) subgroups, based on the predicted protein size. After Key words: bactericidal/permeability-increasing protein (BPI), innate immunity, parotid secretory protein (PSP), palate, lung and nasal epithelium clone (PLUNC), von Ebner minor salivary gland protein (VEMSGP). Abbreviations used: BPI...
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Biochem Soc Trans (2003) 31 (4): 776.
Published: 01 August 2003
... Applications of Mannan-Binding Lectin a Biochemical Society Focused Meeting held at Royal College of Physicians of Edinburgh, 20 March 2003 20 March 2003 © 2003 Biochemical Society 2003 collectin innate immunity mannan-binding lectin (MBL) MBL therapy Abbreviation used: MBL...
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Biochem Soc Trans (2003) 31 (4): 745–747.
Published: 01 August 2003
... into the bloodstream. It is believed to be an important component of innate immunity, acting as an ante-antibody and/or as a disease modifier. It is thought to influence disorders as diverse as meningococcal disease, rheumatoid arthritis, cystic fibrosis and recurrent miscarriage. Lack of MBL may be most relevant...
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Biochem Soc Trans (2003) 31 (4): 806–809.
Published: 01 August 2003
... Society 2003 bactericidal/permeability-increasing protein (BPI) gene expression gene structure host defence innate immunity lipopolysaccharide-binding protein (LBP) palate lung and nasal epithelium clone (PLUNC) Abbreviations used: BASE, breast cancer and salivary expressed; BPI...
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Biochem Soc Trans (2003) 31 (4): 763–767.
Published: 01 August 2003
...J.C. Jensenius; P.H. Jensen; K. McGuire; J.L. Larsen; S. Thiel Mannan-binding lectin (MBL) is a plasma protein involved in the innate immune response. It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization...
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Biochem Soc Trans (2003) 31 (3): 648–651.
Published: 01 June 2003
... Society Focused Meeting held at Novartis, Horsham, 3 February 2003 20 January 2003 © 2003 Biochemical Society 2003 bacterial infection fruit fly innate immunity signal transduction Abbreviations used: PRR, pattern recognition receptor; TLR, Toll-like receptor; LPS...
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Biochem Soc Trans (2002) 30 (6): 971–978.
Published: 01 November 2002
... complement regulation Factor H protein family haemolytic uraemic syndrome immunevasion innate immunity microbial evasion strategy CRASP, complement regulatory-acquiring surface protein FHL-1, Factor H-like protein FHR, Factor H-related protein HUS, haemolytic uraemic syndrome RCA, regulator...
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Biochem Soc Trans (2002) 30 (6): 983–987.
Published: 01 November 2002
... of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, U.S.A. (e-mail michael.holers@uchsc.edu ) © 2002 Biochemical Society 2002 B-lymphocyte co-crystal structure complement control protein innate immunity CR, complement receptor EBV, Epstein-Barr virus FDC...
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Biochem Soc Trans (2002) 30 (6): 1001–1006.
Published: 01 November 2002
...G. J. Arlaud; C. Gaboriaud; N. M. Thielens; V. Rossi The classical complement pathway is a major element of innate immunity against infection, and is also involved in immune tolerance, graft rejection and various pathologies. This pathway is triggered by C1, a multimolecular protease formed from...
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Biochem Soc Trans (2001) 29 (6): 853–859.
Published: 01 November 2001
...: it is often called the ‘septic syndrome’. Our current understanding of the innate immune system is deeply rooted in the study of sepsis. The chain of events linking infection to tissue injury and cardiovascular collapse is not obvious, and affirmation of the concept required three major discoveries. First...
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Biochem Soc Trans (2001) 29 (4): 598–601.
Published: 01 August 2001
... for innate immunity. Many of these peptides form amphipathic secondary structures (α-helices and β-sheets) which can selectively interact with anionic bacterial membranes by electrostatic interaction. Rapid, peptide-induced membrane permeabilization is an effective mechanism of anti-microbial action...
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Biochem Soc Trans (2000) 28 (5): 545–550.
Published: 01 October 2000
...R. B. Sim; A. Laich The complement system in blood plasma is a major mediator of innate immune defence. The function of complement is to recognize, then opsonize or lyse, particulate materials, including bacteria, yeasts and other microrganisms, host cell debris and altered host cells. Recognition...