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Articles

Guanylate-binding proteins in virus infection

Simran Chhabra, Manjula Kalia

Biochem Soc Trans (2023) 51 (4): 1621–1633.

https://doi.org/10.1042/BST20221500

Published: 03 August 2023

... 2023 GTPases inflammasome innate immunity interferons trafficking virus replication The innate immune system is the primary line of defence against infection. In vertebrates, specialized pattern recognition receptors (PRRs) sense the pathogen associated molecular patterns (PAMPs...

View article titled, Guanylate-binding proteins in virus infection

Articles

γ-Secretase fanning the fire of innate immunity

Chenge Liu, Cyrus Nikain, Yue-Ming Li

Biochem Soc Trans (2023) 51 (4): 1597–1610.

https://doi.org/10.1042/BST20221445

Published: 14 July 2023

...Chenge Liu; Cyrus Nikain; Yue-Ming Li Innate immunity is the first line of defense against pathogens, alerting the individual cell and surrounding area to respond to this potential invasion. γ-secretase is a transmembrane protease complex that plays an intricate role in nearly every stage...

View article titled, γ-Secretase fanning the fire of innate immunity

Articles

Mechanisms of impairment of interferon production by SARS-CoV-2

In Collection

Coronavirus

Huy-Dung Hoang, Parisa Naeli, Tommy Alain, Seyed Mehdi Jafarnejad

Biochem Soc Trans (2023) 51 (3): 1047–1056.

https://doi.org/10.1042/BST20221037

Published: 18 May 2023

...Huy-Dung Hoang; Parisa Naeli; Tommy Alain; Seyed Mehdi Jafarnejad Interferons (IFNs) are crucial components of the cellular innate immune response to viral infections. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a remarkable capacity to suppress the host IFN...

View article titled, Mechanisms of impairment of interferon production by SARS-CoV-2

Articles

cGAS–STING signalling in cancer: striking a balance with chromosomal instability

Bruno Beernaert, Eileen E. Parkes

Biochem Soc Trans (2023) 51 (2): 539–555.

https://doi.org/10.1042/BST20220838

Published: 06 March 2023

... by the nucleic acid sensor cGAS, leading to the production of the second messenger 2′3′-cGAMP and activation of the critical hub of innate immune signalling STING. Activation of this immune pathway should instigate the influx and activation of immune cells, resulting in the eradication of cancer cells...

View article titled, cGAS–STING signalling in cancer: striking a balance with chromosomal instability

Articles

RNA interference, an emerging component of antiviral immunity in mammals

Dario Pasquale Anobile, Enzo Z. Poirier

Biochem Soc Trans (2023) 51 (1): 137–146.

https://doi.org/10.1042/BST20220385

Published: 06 January 2023

... of antiviral RNAi to immunity at the host level. Correspondence: Enzo Z. Poirier ( enzo.poirier@curie.fr ) 10 10 2022 12 12 2022 13 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 innate immunity RNA interference...

View article titled, RNA interference, an emerging component of antiviral immunity in mammals

Articles

ERK1/2 in immune signalling

Richard M. Lucas, Lin Luo, Jennifer L. Stow

Biochem Soc Trans (2022) 50 (5): 1341–1352.

https://doi.org/10.1042/BST20220271

Published: 25 October 2022

... into its recruitment, compartmentalisation and activation in cells of the innate immune system. In this review, we summarise the typical activation of ERK1/2 in growth factor receptor pathways before discussing its known roles in immune cell signalling with a focus downstream of TLRs. We examine emerging...

View article titled, ERK1/2 in immune signalling

Articles

Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

Matthew J. A. Hein, Marc Kvansakul, Fung T. Lay, Thanh Kha Phan, Mark D. Hulett

Biochem Soc Trans (2022) 50 (1): 423–437.

https://doi.org/10.1042/BST20200884

Published: 11 January 2022

... Attribution License 4.0 (CC BY) . cancer defensin host defence peptide infection innate immunity lipid Host defence peptides (HDPs; also referred to as cationic antimicrobial peptides) are key components of the innate immune system across all kingdoms of life [ 1 , 2 ]. Defensins...

View article titled, Defensin–lipid interactions in membrane targeting: mechanisms of action and opportunities for the development of antimicrobial and anticancer therapeutics

Articles

Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium

Lisa Scarfe, Gillian M. Mackie, Kendle M. Maslowski

Biochem Soc Trans (2021) 49 (6): 2601–2610.

https://doi.org/10.1042/BST20210365

Published: 02 December 2021

... inflammasome innate immunity nod-like receptors The intestinal tract is a complex environment, which must achieve both nutrient absorption and protection from pathogens. The combination of food particles, the microbiota, various cell types and potential pathogens requires delicate cross-talk...

View article titled, Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium

Articles

An integrated view of innate immune mechanisms in C. elegans

Benjamin W. Harding, Jonathan J. Ewbank

Biochem Soc Trans (2021) 49 (5): 2307–2317.

https://doi.org/10.1042/BST20210399

Published: 08 October 2021

.... Studies with the model animal C. elegans have uncovered a range of examples wherein innate immune responses are intimately connected with different homeostatic mechanisms, and can influence reproduction, ageing and neurodegeneration, as well as various other aspects of its biology. Here we provide a short...

View article titled, An integrated view of innate immune mechanisms in C. elegans

Articles

Great balls of fire: activation and signalling of inflammatory caspases

Georgia Bateman, Benjamin Hill, Ryan Knight, Dave Boucher

Biochem Soc Trans (2021) 49 (3): 1311–1324.

https://doi.org/10.1042/BST20200986

Published: 01 June 2021

...Georgia Bateman; Benjamin Hill; Ryan Knight; Dave Boucher Innate immune responses are tightly regulated by various pathways to control infections and maintain homeostasis. One of these pathways, the inflammasome pathway, activates a family of cysteine proteases called inflammatory caspases...

View article titled, Great balls of fire: activation and signalling of inflammatory caspases

Articles

Mitochondrial DNA in innate immune responses against infectious diseases

Palamou Das, Oishee Chakrabarti

Biochem Soc Trans (2020) 48 (6): 2823–2838.

https://doi.org/10.1042/BST20200687

Published: 06 November 2020

...Palamou Das; Oishee Chakrabarti Mitochondrial DNA (mtDNA) can initiate an innate immune response when mislocalized in a compartment other than the mitochondrial matrix. mtDNA plays significant roles in regulating mitochondrial dynamics as well as mitochondrial unfolded protein response (UPR...

View article titled, Mitochondrial DNA in innate immune responses against infectious diseases

Articles

Innate immune receptors in type 1 diabetes: the relationship to cell death-associated inflammation

In Collection

Celebrating 100 years of insulin research

Tae Kang Kim, Myung-Shik Lee

Biochem Soc Trans (2020) 48 (3): 1213–1225.

https://doi.org/10.1042/BST20200131

Published: 08 June 2020

...Tae Kang Kim; Myung-Shik Lee The importance of innate immunity in host defense and inflammatory responses has been clearly demonstrated after the discovery of innate immune receptors such as Toll-like receptors (TLRs) or Nucleotide-binding oligomerization domain-containing protein (Nod)-like...

View article titled, Innate immune receptors in type 1 diabetes: the relationship to cell death-associated inflammation

Articles

Bacterial DUBs: deubiquitination beyond the seven classes

Thomas Hermanns, Kay Hofmann

Biochem Soc Trans (2019) 47 (6): 1857–1866.

https://doi.org/10.1042/BST20190526

Published: 17 December 2019

... this classification. host–pathogen interactions innate immunity Legionella protease domains ubiquitins The discovery that the ElaD protein encoded by many strains of Escherichia coli is active as a DUB [ 25 ] was surprising: most bacterial DUBs are strain-specific and limited to pathogenic forms...

View article titled, Bacterial DUBs: deubiquitination beyond the seven classes

Articles

Bacterial glycans and their interactions with lectins in the innate immune system

Mariano Prado Acosta, Bernd Lepenies

Biochem Soc Trans (2019) 47 (6): 1569–1579.

https://doi.org/10.1042/BST20170410

Published: 14 November 2019

...Mariano Prado Acosta; Bernd Lepenies Bacterial surfaces are rich in glycoconjugates that are mainly present in their outer layers and are of great importance for their interaction with the host innate immune system. The innate immune system is the first barrier against infection and recognizes...

View article titled, Bacterial glycans and their interactions with lectins in the innate immune system

Articles

Chitinase-like proteins as regulators of innate immunity and tissue repair: helpful lessons for asthma?

Tara E. Sutherland

Biochem Soc Trans (2018) 46 (1): 141–151.

https://doi.org/10.1042/BST20170108

Published: 19 January 2018

... innate immunity tissue remodelling Glycoside hydrolase family 18 (GH18) proteins encompass the enzymatically active chitinases and enzymatically inactive chitinase-like proteins (CLPs). Chitinases hydrolyse glycosidic bonds of chitin, an abundant polysaccharide found as a structural component...

View article titled, Chitinase-like proteins as regulators of innate immunity and tissue repair: helpful lessons for asthma?

Articles

Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling

Kenji Funami, Misako Matsumoto, Hiroyuki Oshiumi, Fuyuhiko Inagaki, Tsukasa Seya

Biochem Soc Trans (2017) 45 (4): 929–935.

https://doi.org/10.1042/BST20160259

Published: 16 June 2017

... on behalf of the Biochemical Society 2017 endotoxin innate immunity myeloid cells TICAM-2 adaptor TLR4 Toll-like receptors (TLRs) are pattern recognition receptors which recognize pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs) [ 1 ]. TLRs are type I integral...

View article titled, Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling

Articles

Tribbles role in reproduction

Shaghayegh Basatvat, Deborah Angela Louise Carter, Endre Kiss-Toth, Alireza Fazeli

Biochem Soc Trans (2015) 43 (5): 1116–1121.

https://doi.org/10.1042/BST20150121

Published: 09 October 2015

... of biological processes ranging from cell proliferation to metabolism, immunity, inflammation and carcinogenesis. Innate immune system plays a pivotal role during the regulation of reproductive processes that allows successful creation of an offspring. Its involvement initiates from fertilization of the oocyte...

View article titled, Tribbles role in reproduction

Articles

Liver X receptors in immune cell function in humans

Kirsty E. Waddington, Elizabeth C. Jury, Inés Pineda-Torra

Biochem Soc Trans (2015) 43 (4): 752–757.

https://doi.org/10.1042/BST20150112

Published: 03 August 2015

... activation. 1 To whom correspondence should be addressed (email i.torra@ucl.ac.uk ) . 12 5 2015 © 2015 Authors; published by Portland Press Limited 2015 adaptive immunity cholesterol gene regulation innate immunity lipid rafts liver X receptors (LXRs) LXR...

View article titled, Liver X receptors in immune cell function in humans

Articles

Conflict RNA modification, host–parasite co-evolution, and the origins of DNA and DNA-binding proteins

Paul J. McLaughlin, Liam P. Keegan

Biochem Soc Trans (2014) 42 (4): 1159–1167.

https://doi.org/10.1042/BST20140147

Published: 11 August 2014

... as self RNA and to suppress activation of innate immune sensors that detect viral dsRNA. 1 Dedicated to the memory of Walter Gehring. 2 To whom correspondence should be addressed (email Liam.Keegan@igmm.ed.ac.uk ). 3 6 2014 © The Authors Journal compilation © 2014...

View article titled, Conflict RNA modification, host–parasite co-evolution, and the origins of DNA and DNA-binding proteins

Articles

Protein kinase networks that limit TLR signalling

Kristopher Clark

Biochem Soc Trans (2014) 42 (1): 11–24.

https://doi.org/10.1042/BST20130124

Published: 23 January 2014

... the innate immune response by negatively regulating TLR signalling and/or promoting the secretion of anti-inflammatory cytokines. I present my discoveries on the key roles of the IKK (inhibitor of nuclear factor κB kinase)-related kinases and the SIKs (salt-inducible kinases) in limiting innate immunity...

View article titled, Protein kinase networks that limit TLR signalling

Articles

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

Madhumita Dandapani, D. Grahame Hardie

Biochem Soc Trans (2013) 41 (2): 687–693.

https://doi.org/10.1042/BST20120351

Published: 21 March 2013

... should be addressed (email d.g.hardie@dundee.ac.uk ). 7 12 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 AMP-activated protein kinase (AMPK) cancer inflammation innate immunity metabolism Figure 1 compares the typical pathways of metabolism...

View article titled, AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

Articles

Microvesicles and exosomes as vehicles between protozoan and host cell communication

Poliana Deolindo, Ingrid Evans-Osses, Marcel Ivan Ramirez

Biochem Soc Trans (2013) 41 (1): 252–257.

https://doi.org/10.1042/BST20120217

Published: 29 January 2013

... an energy-dependent mechanism, displaying differences in synthesis, size, function and composition [ 2 ]. exosome innate immunity microvesicle parasite–host cell interaction phosphatidylserine Extracellular vesicles were first reported many years ago [ 1 ]. In the subsequent decades...

View article titled, Microvesicles and exosomes as vehicles between protozoan and host cell communication

Articles

Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule

Ralf R. Schumann

Biochem Soc Trans (2011) 39 (4): 989–993.

https://doi.org/10.1042/BST0390989

Published: 20 July 2011

... help in further elucidating the mechanism of LBP and its role in innate immunity and disease. 1 email ralf.schumann@charite.de 31 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 acute-phase protein endotoxin recognition innate immunity...

View article titled, Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule

Articles

The Molecular Biology of Inflammatory Bowel Diseases

Anthony P. Corfield, Heather M. Wallace, Chris S.J. Probert

Biochem Soc Trans (2011) 39 (4): 1057–1060.

https://doi.org/10.1042/BST0391057

Published: 20 July 2011

... acetylation, protein modification and microRNAs. adaptive immunity animal model gastrointestinal tract inflammatory bowel disease (IBD) innate immunity microflora pathogenicity The IBDs (inflammatory bowel diseases) are mainly represented by UC (ulcerative colitis) and Crohn's disease...

View article titled, The Molecular Biology of Inflammatory Bowel Diseases

Articles

PLUNC: a multifunctional surfactant of the airways

Jennifer Bartlett, Lokesh Gakhar, Jon Penterman, Pradeep Singh, Rama K. Mallampalli, Edith Porter, Paul B. McCray, Jr

Biochem Soc Trans (2011) 39 (4): 1012–1016.

https://doi.org/10.1042/BST0391012

Published: 20 July 2011

... with the innate immune defence molecules BPI (bactericidal/permeability-increasing protein) and LBP (lipopolysaccharide-binding protein), it has been difficult to define the functions of PLUNC. Based on its marked hydrophobicity and expression pattern, we hypothesized that PLUNC is an airway surfactant. We found...

View article titled, PLUNC: a multifunctional surfactant of the airways

Articles

Inflammasome activation: from inflammatory disease to infection

Aisling Dunne

Biochem Soc Trans (2011) 39 (2): 669–673.

https://doi.org/10.1042/BST0390669

Published: 22 March 2011

...Aisling Dunne The recognition of pathogen-derived molecules by the innate immune system is mediated by a number of receptors, including members of the TLR (Toll-like receptor), RLH [RIG (retinoic acid-inducible gene)-like helicase] and the NLR (NOD-like receptor) families. NLRs in particular...

View article titled, Inflammasome activation: from inflammatory disease to infection

Articles

The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia

Tracy Hussell, Mary M. Cavanagh

Biochem Soc Trans (2009) 37 (4): 811–813.

https://doi.org/10.1042/BST0370811

Published: 22 July 2009

...Tracy Hussell; Mary M. Cavanagh The activity of innate immunity is not simply dictated by the presence of an antigen but also by the balance between negative regulatory and immune potentiator pathways. Even in the absence of antigen, innate immunity can ‘inflame’ if negative regulators are absent...

View article titled, The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia

Articles

Mannose-binding lectin genetics: from A to Z

Peter Garred

Biochem Soc Trans (2008) 36 (6): 1461–1466.

https://doi.org/10.1042/BST0361461

Published: 19 November 2008

... of human MBL2 genetics. 1 email garred@post5.tele.dk 21 8 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 innate immunity mannose-binding lectin (MBL) mannan-binding lectin MBL1P1 opsonin pseudogene In recent years, there has been an emerging...

View article titled, Mannose-binding lectin genetics: from A to Z

Articles

Lectins: past, present and future 1

Nathan Sharon

Biochem Soc Trans (2008) 36 (6): 1457–1460.

https://doi.org/10.1042/BST0361457

Published: 19 November 2008

... applications of the knowledge gained. The review ends with speculations about future developments in lectin research and applications. 2 email nathan.sharon@weizmann.ac.il 12 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cancer carbohydrate innate immunity...

View article titled, Lectins: past, present and future 1

Articles

Lessons learned from murine models of mannose-binding lectin deficiency

Kazue Takahashi

Biochem Soc Trans (2008) 36 (6): 1487–1490.

https://doi.org/10.1042/BST0361487

Published: 19 November 2008

...Kazue Takahashi MBL (mannose-binding lectin) is a pattern recognition molecule and a component of innate immunity, the first line of the host defence system against foreign bodies and pathogens. MBL deficiency is common in humans and has been associated with immunodeficiency. We have generated...

View article titled, Lessons learned from murine models of mannose-binding lectin deficiency

Articles

Nod1 and Nod2 in innate immunity and human inflammatory disorders

L. Le Bourhis, S. Benko, S.E. Girardin

Biochem Soc Trans (2007) 35 (6): 1479–1484.

https://doi.org/10.1042/BST0351479

Published: 23 November 2007

... pathways in response to bacteria by inducing signalling pathways such as NF-κB (nuclear factor κB) and MAPKs (mitogen-activated protein kinases). The Nod proteins act independently of the TLR (Toll-like receptor) cascade, but potently synergize with the latter to trigger innate immune responses to microbes...

View article titled, Nod1 and Nod2 in innate immunity and human inflammatory disorders

Articles

Genetic polymorphisms within the human Toll-like receptor 2 subfamily

R.I. Tapping, K.O. Omueti, C.M. Johnson

Biochem Soc Trans (2007) 35 (6): 1445–1448.

https://doi.org/10.1042/BST0351445

Published: 23 November 2007

...R.I. Tapping; K.O. Omueti; C.M. Johnson Infectious disease is a formidable selective force in Nature as is evident from the complexity of immune systems across multicellular species. TLRs (Toll-like receptors) constitute central pattern-recognition molecules of the innate immune system that sense...

View article titled, Genetic polymorphisms within the human Toll-like receptor 2 subfamily

Articles

Paneth cell defensins: key effector molecules of innate immunity

C.L. Bevins

Biochem Soc Trans (2006) 34 (2): 263–266.

https://doi.org/10.1042/BST0340263

Published: 20 March 2006

...C.L. Bevins Antimicrobial peptides are fundamental effector molecules of innate immunity, utilized in host defence by virtually all organisms studied. These gene-encoded peptides have direct antibiotic activity against a wide range of bacteria and other microbes. In humans and other mammals...

View article titled, Paneth cell defensins: key effector molecules of innate immunity

Articles

Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity

P.S. Hiemstra

Biochem Soc Trans (2006) 34 (2): 276–278.

https://doi.org/10.1042/BST0340276

Published: 20 March 2006

...P.S. Hiemstra Innate immunity provides an effective first line of defence against infections. This is of particular importance in the lung, an organ that is exposed to a large number of pathogens that are inhaled. Antimicrobial peptides play an important role in the defence against these pathogens...

View article titled, Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity

Articles

Characterization of AWAP IV, the C-terminal domain of the avian protein AWAK

C.L. Townes, P. Milona, J. Hall

Biochem Soc Trans (2006) 34 (2): 267–269.

https://doi.org/10.1042/BST0340267

Published: 20 March 2006

... protein) AWAP IV innate immunity whey acidic protein domain (WAP domain) The innate immune system of higher eukaryotes provides the first line of defence against pathogenic invasion of the host, and includes the synthesis of small (1–10 kDa), structurally diverse AMPs (antimicrobial peptides...

View article titled, Characterization of AWAP IV, the C-terminal domain of the avian protein AWAK

Articles

Four BPI (bactericidal/permeability-increasing protein)-like genes expressed in the mouse nasal, oral, airway and digestive epithelia

E.E. LeClair

Biochem Soc Trans (2003) 31 (4): 801–805.

https://doi.org/10.1042/bst0310801

Published: 01 August 2003

...) and long (l) subgroups, based on the predicted protein size. After Key words: bactericidal/permeability-increasing protein (BPI), innate immunity, parotid secretory protein (PSP), palate, lung and nasal epithelium clone (PLUNC), von Ebner minor salivary gland protein (VEMSGP). Abbreviations used: BPI...

View article titled, Four BPI (bactericidal/permeability-increasing protein)-like genes expressed in the mouse nasal, oral, airway and digestive epithelia

Articles

Consensus statement on the future of mannan-binding lectin (MBL)-replacement therapy

D.C. Kilpatrick

Biochem Soc Trans (2003) 31 (4): 776.

https://doi.org/10.1042/bst0310776

Published: 01 August 2003

... Applications of Mannan-Binding Lectin a Biochemical Society Focused Meeting held at Royal College of Physicians of Edinburgh, 20 March 2003 20 March 2003 © 2003 Biochemical Society 2003 collectin innate immunity mannan-binding lectin (MBL) MBL therapy Abbreviation used: MBL...

View article titled, Consensus statement on the future of mannan-binding lectin (MBL)-replacement therapy

Articles

Introduction to mannan-binding lectin

D.C. Kilpatrick

Biochem Soc Trans (2003) 31 (4): 745–747.

https://doi.org/10.1042/bst0310745

Published: 01 August 2003

... into the bloodstream. It is believed to be an important component of innate immunity, acting as an ante-antibody and/or as a disease modifier. It is thought to influence disorders as diverse as meningococcal disease, rheumatoid arthritis, cystic fibrosis and recurrent miscarriage. Lack of MBL may be most relevant...

View article titled, Introduction to mannan-binding lectin

Articles

Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families

C.D. Bingle, C.J. Craven

Biochem Soc Trans (2003) 31 (4): 806–809.

https://doi.org/10.1042/bst0310806

Published: 01 August 2003

... Society 2003 bactericidal/permeability-increasing protein (BPI) gene expression gene structure host defence innate immunity lipopolysaccharide-binding protein (LBP) palate lung and nasal epithelium clone (PLUNC) Abbreviations used: BASE, breast cancer and salivary expressed; BPI...

View article titled, Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families

Articles

Recombinant mannan-binding lectin (MBL) for therapy

J.C. Jensenius, P.H. Jensen, K. McGuire, J.L. Larsen, S. Thiel

Biochem Soc Trans (2003) 31 (4): 763–767.

https://doi.org/10.1042/bst0310763

Published: 01 August 2003

...J.C. Jensenius; P.H. Jensen; K. McGuire; J.L. Larsen; S. Thiel Mannan-binding lectin (MBL) is a plasma protein involved in the innate immune response. It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization...

View article titled, Recombinant mannan-binding lectin (MBL) for therapy

Articles

Toll and Toll-like receptors in Drosophila

H. Bilak, S. Tauszig-Delamasure, J.-L. Imler

Biochem Soc Trans (2003) 31 (3): 648–651.

https://doi.org/10.1042/bst0310648

Published: 01 June 2003

... Society Focused Meeting held at Novartis, Horsham, 3 February 2003 20 January 2003 © 2003 Biochemical Society 2003 bacterial infection fruit fly innate immunity signal transduction Abbreviations used: PRR, pattern recognition receptor; TLR, Toll-like receptor; LPS...

View article titled, Toll and Toll-like receptors in Drosophila

Articles

Factor H family proteins: on complement, microbes and human diseases

P. F. Zipfel, C. Skerka, J. Hellwage, S. T. Jokiranta, S. Meri, V. Brade, P. Kraiczy, M. Noris, G. Remuzzi

Biochem Soc Trans (2002) 30 (6): 971–978.

https://doi.org/10.1042/bst0300971

Published: 01 November 2002

... complement regulation Factor H protein family haemolytic uraemic syndrome immunevasion innate immunity microbial evasion strategy CRASP, complement regulatory-acquiring surface protein FHL-1, Factor H-like protein FHR, Factor H-related protein HUS, haemolytic uraemic syndrome RCA, regulator...

View article titled, Factor H family proteins: on complement, microbes and human diseases

Articles

Structure of complement receptor (CR) 2 and CR2-C3d complexes

J. Hannan, K. Young, G. Szakonyi, M. J. Overduin, S. J. Perkins, X. Chen, V. M. Holers

Biochem Soc Trans (2002) 30 (6): 983–987.

https://doi.org/10.1042/bst0300983

Published: 01 November 2002

... of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, U.S.A. (e-mail michael.holers@uchsc.edu ) © 2002 Biochemical Society 2002 B-lymphocyte co-crystal structure complement control protein innate immunity CR, complement receptor EBV, Epstein-Barr virus FDC...

View article titled, Structure of complement receptor (CR) 2 and CR2-C3d complexes

Articles

Structural biology of Cl

G. J. Arlaud, C. Gaboriaud, N. M. Thielens, V. Rossi

Biochem Soc Trans (2002) 30 (6): 1001–1006.

https://doi.org/10.1042/bst0301001

Published: 01 November 2002

...G. J. Arlaud; C. Gaboriaud; N. M. Thielens; V. Rossi The classical complement pathway is a major element of innate immunity against infection, and is also involved in immune tolerance, graft rejection and various pathologies. This pathway is triggered by C1, a multimolecular protease formed from...

View article titled, Structural biology of Cl

Articles

Sepsis begins at the interface of pathogen and host

B. Beutler

Biochem Soc Trans (2001) 29 (6): 853–859.

https://doi.org/10.1042/bst0290853

Published: 01 November 2001

...: it is often called the ‘septic syndrome’. Our current understanding of the innate immune system is deeply rooted in the study of sepsis. The chain of events linking infection to tissue injury and cardiovascular collapse is not obvious, and affirmation of the concept required three major discoveries. First...

View article titled, Sepsis begins at the interface of pathogen and host

Articles

Why and how are peptide-lipid interactions utilized for self defence?

K. Matsuzaki

Biochem Soc Trans (2001) 29 (4): 598–601.

https://doi.org/10.1042/bst0290598

Published: 01 August 2001

... for innate immunity. Many of these peptides form amphipathic secondary structures (α-helices and β-sheets) which can selectively interact with anionic bacterial membranes by electrostatic interaction. Rapid, peptide-induced membrane permeabilization is an effective mechanism of anti-microbial action...

View article titled, Why and how are peptide-lipid interactions utilized for self defence?

Articles

Serine proteases of the complement system

R. B. Sim, A. Laich

Biochem Soc Trans (2000) 28 (5): 545–550.

https://doi.org/10.1042/bst0280545

Published: 01 October 2000

...R. B. Sim; A. Laich The complement system in blood plasma is a major mediator of innate immune defence. The function of complement is to recognize, then opsonize or lyse, particulate materials, including bacteria, yeasts and other microrganisms, host cell debris and altered host cells. Recognition...

View article titled, Serine proteases of the complement system

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