...: these are termed TOS [TOR (target of rapamycin) signalling] motifs. mTORC1 contains GβL, which is also found in mTORC2. 1 email C.G.Proud@soton.ac.uk 5 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 elongation factor initiation factor mammalian target...

...; substitution of the aspartate residues did not affect the rate of GTP hydrolysis. This is consistent with the NMR data, which showed the largest changes in chemical shifts in the two isoleucine residues upon binding of DIDDI to eIF5B [ 47 ]. G-protein initiation factor ribosomal subunit joining...

... is necessary for protein synthesis. Phosphorylation of translation initiation factors offers a cost-effective and rapid way to adapt to physiological and environmental changes, and there is increasing evidence that many of these factors are subject to multiple regulatory phosphorylation events. The present...

...R.J. Jackson Of all the steps in mRNA translation, initiation is the one that differs most radically between prokaryotes and eukaryotes. Not only is there no equivalent of the prokaryotic Shine–Dalgarno rRNA–mRNA interaction, but also what requires only three initiation factor proteins (aggregate...

...C. G. Proud; X. Wang; J. V. Patel; L. E. Campbell; M. Kleijn; W. Li; G. J. Browne Protein synthesis in mammalian cells is regulated through alterations in the states of phosphorylation of eukaryotic initiation factors and elongation factors (eIFs and eEFs respectively) and of other regulatory...