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Biochem Soc Trans (2022) 50 (1): 597–607.
Published: 25 February 2022
..., and the involved mechanisms or molecular pathways during viral infection. Meanwhile, the existing issues are also discussed. Additionally, the important technologies or agents, including siRNA, gene editing, and myosin inhibitors, would facilitate dissecting the actions and mechanisms for described and undescribed...
Biochem Soc Trans (2020) 48 (3): 933–943.
Published: 26 May 2020
...Glorianne Lazaro; Eleftherios Kostaras; Igor Vivanco Aberrant activation of the PI3K pathway is one of the commonest oncogenic events in human cancer. AKT is a key mediator of PI3K oncogenic function, and thus has been intensely pursued as a therapeutic target. Multiple AKT inhibitors, broadly...
Biochem Soc Trans (2020) 48 (1): 291–300.
Published: 12 February 2020
...William G. Kerr; Chiara Pedicone; Shawn Dormann; Angela Pacherille; John D. Chisholm Modulating the activity of the Src Homology 2 (SH2) — containing Inositol 5′-Phosphatase (SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional method of influencing cell signaling...
Biochem Soc Trans (2016) 44 (3): 932–936.
Published: 09 June 2016
...Hershna Patel; Andreas Kukol Sequence variations in the binding sites of influenza A proteins are known to limit the effectiveness of current antiviral drugs. Clinically, this leads to increased rates of virus transmission and pathogenicity. Potential influenza A inhibitors are continually being...
Lisardo Boscá, Silvia González-Ramos, Patricia Prieto, María Fernández-Velasco, Marina Mojena, Paloma Martín-Sanz, Susana Alemany
Biochem Soc Trans (2015) 43 (4): 740–744.
Published: 03 August 2015
... remodelling and epigenetic changes [ 37 , 39 ]. To modulate the balance between the metabolic and genomic actions of PKM2, several activators and inhibitors have been developed: N, N′-diarylsulfonamide NCGC00185916 (DASA-58) and thieno-[3,2-b]pyrrole [3,2-d]pyridazinone NCGC00186528 (TEPP-46) are activators...
Biochem Soc Trans (2000) 28 (6): 871–872.
Published: 01 December 2000
... inhibitors phospholipase A phospholipase C PLA, phospholipase A Lipids and Signalling: Oxylipins 3 Experimental Etiolated 3-day-old pea seedlings were the object of investigation. Protein kinase activity was rou- tinely assayed at 30 "C by precipitation of szP- labelled phosphorylated protein...