... the bioactivity of the IL-36 subfamily and its role in the pathogenesis of intestinal diseases such as inflammatory bowel disease, colorectal cancer, gut dysbacteriosis and infection, and proposes that IL-36 may be a target for novel therapeutic strategies to prevent or treat intestinal diseases...

... evidence linking type 2 immune responses with the aetiology of IBD. The breakdown of intestinal homeostasis may lead to aberrant immune responses against luminal antigens and eventually lead to inflammatory bowel diseases (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC). Although...

...Patrick A. Lewis; Dario R. Alessi LRRK2 (leucine-rich repeat kinase 2) is a gene of unknown function that has been linked to a number a human diseases, including PD (Parkinson's disease), IBD (inflammatory bowel disease), leprosy and cancer. The papers from the LRRK2: Function and Dysfunction...

...Alexander J.P. Edwards; Sylvia L.F. Pender IBDs (inflammatory bowel diseases) are lifelong manifestations that significantly impair the quality of life of those who suffer from them. Although many therapies are now available, including immunomodulatory drugs such as Infliximab which have efficacy...

... mediators would probably result in excessive losses of water and electrolytes that are not counterbalanced by any advantages, possibly related to extrusion of intestinal parasites or micro-organisms from an evolutionary point of view. The Molecular Biology of Inflammatory Bowel Diseases...