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Keywords: inflammation
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Articles
Biochem Soc Trans (2022) 50 (2): 799–811.
Published: 28 March 2022
...). Published by Portland Press Limited on behalf of the Biochemical Society 2022 inflammation linear ubiquitination LUBAC LUBAC inhibitors neurodegeneration Ubiquitin is a 76-amino acid protein that is expressed in all eukaryotic cells; it modifies substrate proteins to regulate...
Articles
Biochem Soc Trans (2022) 50 (1): 21–32.
Published: 22 February 2022
...Kristian H. Rasmussen; Clare L. Hawkins Macrophages play an integral role in initiating innate immune defences and regulating inflammation. They are also involved in maintaining homeostasis and the resolution of inflammation, by promoting tissue repair and wound healing. There is evidence that like...
Articles
Biochem Soc Trans (2021) 49 (6): 2495–2507.
Published: 02 December 2021
... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...
Articles
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
...Marina Diotallevi; Faseeha Ayaz; Thomas Nicol; Mark J. Crabtree Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has...
Articles
Biochem Soc Trans (2020) 48 (6): 2525–2537.
Published: 26 November 2020
... BY) . Open access for this article was enabled by the participation of University of Strathclyde in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. inflammation modulators PARs The challenge of targeting...
Articles
Biochem Soc Trans (2020) 48 (1): 1–14.
Published: 12 February 2020
... of the main etiological types of sepsis. Correspondence: Mihai G. Netea ( Mihai.Netea@radboudumc.nl ) 30 10 2019 16 1 2020 20 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 biomarker infection inflammation...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (6): 1581–1595.
Published: 26 November 2019
...) . immune cells inflammation LRRK2 Parkinson's disease Rab GTPases The leucine-rich-repeat kinase 2 ( LRRK2 ) gene encodes for a large, multidomain protein encompassing two enzymatic functions at its core. The catalytic core consists of the GTPase domain of the protein, and the serine...
Articles
Biochem Soc Trans (2019) 47 (6): 1921–1930.
Published: 22 November 2019
...Maximilien Euler; Markus H. Hoffmann While there are numerous studies showing that neutrophil extracellular traps (NETs) contribute to autoimmune inflammation and cause bystander tissue injury, human individuals with genetic impairments in NET formation curiously often suffer from exacerbated...
Articles
Biochem Soc Trans (2019) 47 (6): 1679–1687.
Published: 14 November 2019
... inflammation macrophages myocardial infarction Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of wound healing steps that culminate in the formation of an infarct scar ( Figure 1 ). The three phases of the MI response are inflammation, wound healing, and scar...
Articles
Biochem Soc Trans (2018) 46 (3): 649–658.
Published: 09 May 2018
...Julia Y. Chu; Barry McCormick; Sonja Vermeren Inflammation is a complex biological response that serves to protect the body's tissues following harmful stimuli such as infection, irritation or injury and initiates tissue repair. At the start of an inflammatory response, pro-inflammatory mediators...
Articles
Biochem Soc Trans (2018) 46 (3): 631–639.
Published: 09 May 2018
...Andrew Devitt; Helen R. Griffiths; Ivana Milic Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here, we consider apoptotic cell...
Articles
Biochem Soc Trans (2017) 45 (5): 1105–1115.
Published: 12 September 2017
...Philip C. Calder Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n...
Articles
Biochem Soc Trans (2017) 45 (4): 979–985.
Published: 14 July 2017
...Anna M. Kirwan; Yvonne M. Lenighan; Marcella E. O'Reilly; Fiona C. McGillicuddy; Helen M. Roche Metabolic inflammation is a very topical area of research, wherein aberrations in metabolic and inflammatory pathways probably contribute to atherosclerosis, insulin resistance (IR) and type 2 diabetes...
Articles
Biochem Soc Trans (2017) 45 (4): 999–1006.
Published: 14 July 2017
...Jonas Franz; Marco Tarantola; Christoph Riethmüller Tetraspanins are ubiquitous membrane proteins that induce local membrane curvature and hence co-ordinate cell-to-cell contacts. This review highlights their role in inflammation, which requires control of the nano-architecture of attachment sites...
Articles
Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
.... Thus, it is not surprising that lncRNAs have emerged as important players in human pathophysiology. As our body's first line of defense upon infection or injury, inflammation has been implicated in the etiology of several human diseases. At the center of the acute inflammatory response, as well...
Articles
Biochem Soc Trans (2016) 44 (6): 1581–1602.
Published: 02 December 2016
... polyubiquitination and subsequent proteasomal degradation. NF-κB, normally sequestered in the cytosol by IκB, is thereby free to translocate to the nucleus and drive gene transcription ( Figure 2 ). inflammation post-translational modification ubiquitin signalling Post-translational modification...
Articles
Biochem Soc Trans (2016) 44 (4): 1101–1110.
Published: 15 August 2016
... information to enable adaptability, is central to this whole process. Critically, hormesis could improve mitochondrial quantum efficiency, improving the ATP/ROS ratio, whereas inflammation, which is tightly associated with the aging process, might do the opposite. This all suggests that to achieve optimal...
Articles
Biochem Soc Trans (2015) 43 (6): 1247–1252.
Published: 27 November 2015
... by Portland Press Limited 2015 infection inflammation interferons interleukins translation translation initiation In addition to PKR activation, some pathogens induce PERK, which senses ER stress and also shuts down translation by phosphorylating eIF2α [ 15 ] ( Figure 2 ). For example...
Articles
Biochem Soc Trans (2015) 43 (5): 1051–1056.
Published: 09 October 2015
... pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation...
Articles
Biochem Soc Trans (2015) 43 (4): 691–695.
Published: 03 August 2015
... prestonr@tcd.ie ) . 12 12 2014 © 2015 Authors; published by Portland Press Limited 2015 activated protein C anti-coagulant inflammation protease-activated receptor 1 sepsis When vascular injury occurs, a prompt response is required to stem blood loss. This is achieved...
Articles
Biochem Soc Trans (2015) 43 (4): 740–744.
Published: 03 August 2015
... of the microenvironment. Macrophage activation can be classified as pro-inflammatory (M1 polarization) or anti-inflammatory-pro-resolution-deactivation (M2), these profiles coexisting in the course of the immune response and playing a relevant functional role in the onset of inflammation (Figure 1). Several groups have...
Articles
Biochem Soc Trans (2015) 43 (4): 727–733.
Published: 03 August 2015
..., metabolism and nutrient absorption are well studied; but their potential interactions with the enriched numbers of surrounding immune cells remain largely unexplored. This review focuses on alterations in enteroendocrine cell number and peptide secretion during inflammation and disease, highlighting the few...
Articles
Biochem Soc Trans (2014) 42 (6): 1752–1755.
Published: 17 November 2014
... receptor antagonist and soluble tumour necrosis factor (TNF)-receptor type II, and attenuation of TNFα and IL-6. Together, these functions help drive the resolution of inflammation. Disease models of inflammatory arthritis have helped to demonstrate the novel mode of action of BiP in which...
Articles
Biochem Soc Trans (2014) 42 (6): 1490–1497.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 chemokine receptor inflammation lymphocyte function-associated antigen 1 (LFA-1) migration protein kinase C T-cell The ability of T-cells to migrate to various organs and tissues throughout the body is crucial for immune responses to pathogens...
Articles
Biochem Soc Trans (2014) 42 (5): 1316–1320.
Published: 18 September 2014
... elusive, as they seem to adopt different functions dependent on disease progression and the extent of accompanying parenchymal inflammation. Astrocytes may contribute to the clearance of amyloid β-peptide (Aβ) and restrict the spread of inflammation in the brain. Conversely, they may contribute...
Articles
Biochem Soc Trans (2014) 42 (5): 1321–1325.
Published: 18 September 2014
... death and cognitive and behavioural deficits. Neuroinflammation is also a prominent feature of AD brain and considerable evidence indicates that inflammatory events play a significant role in modulating the progression of AD. The role of microglia in AD inflammation has long been acknowledged...
Articles
Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
... in aging and in the pathogenesis of diseases such as inflammation, diabetes and cancer. Since superoxide formation, in particular in mitochondria, is often considered to be an initial step in the pathogenesis of these diseases, improper function of the MnSOD (mitochondrial superoxide dismutase; SOD2) may...
Articles
Biochem Soc Trans (2014) 42 (2): 244–249.
Published: 20 March 2014
... specific roles in several tissues, among which are the regulation of energy expenditure, GLP-1 (glucagon-like peptide 1) secretion and gall bladder filling. An accumulating body of evidence now demonstrates that TGR5 also acts in a number of processes important in inflammation. Most striking...
Articles
Biochem Soc Trans (2014) 42 (2): 538–542.
Published: 20 March 2014
...Usman Ahmed; Paul J. Thornalley; Naila Rabbani OA (osteoarthritis) and RA (rheumatoid arthritis) lead to deterioration of the joints. Early OA is associated with loss of bone due to increased bone remodelling. A role for inflammation is thought to be integral to the pathology. RA is a chronic...
Articles
Biochem Soc Trans (2014) 42 (2): 284–288.
Published: 20 March 2014
...), are mediators of chronic inflammation during atherogenesis. Subsequently, disruption of these organelles is associated with a broad range of disease states including cardiovascular disease and cancer. Cavin-1 is an essential peripheral component of caveolae that stabilizes caveolin-1, the main structural...
Articles
Biochem Soc Trans (2014) 42 (1): 59–62.
Published: 23 January 2014
... (ERK) inflammation interleukin 6-type cytokine Janus kinase (JAK) signal transducer and activator of transcription (STAT) IL (interleukin)-6-type cytokines are critical molecules that determine health and disease in many living organisms (reviewed in [ 1 , 2 ]). The IL-6 family of cytokines...
Articles
Biochem Soc Trans (2014) 42 (1): 177–183.
Published: 23 January 2014
... to identify commonalities between the different functional and cellular systems. Since mycolactone influences fundamental cellular processes (cell division, cell death and inflammation), getting to the root of how mycolactone achieves this could have a profound impact on our understanding of eukaryotic cell...
Articles
Biochem Soc Trans (2013) 41 (2): 687–693.
Published: 21 March 2013
... and is required for the switch from glycolysis (fermentation) to oxidative metabolism when glucose runs low. In mammals, rapidly proliferating cells (including tumour cells) and immune cells involved in inflammation both tend to utilize rapid glucose uptake and glycolysis (termed the Warburg effect or aerobic...
Articles
Biochem Soc Trans (2012) 40 (1): 133–138.
Published: 19 January 2012
...David C. Clarke; Douglas A. Lauffenburger Inflammation is a key physiological response to infection and injury and, although usually beneficial, it can also be damaging to the host. The liver is a prototypical example in this regard because inflammation helps to resolve liver injury, but it also...
Articles
Biochem Soc Trans (2011) 39 (6): 1619–1627.
Published: 21 November 2011
...Wenda Ramma; Asif Ahmed It has been proposed that either excessive inflammation or an imbalance in angiogenic factors cause pre-eclampsia. In the present review, the arguments for and against the role of inflammation and/or angiogenic imbalance as the cause of pre-eclampsia are discussed...
Articles
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
...-inducible factor (HIF) inflammation vascular endothelial growth factor (VEGF) In 1979, Dvorak et al. [ 1 ] reported the discovery of a new molecule they called VPF (vascular permeability factor). It was later renamed VEGF (vascular endothelial growth factor) [ 2 ]. This molecule became the subject...
Articles
Biochem Soc Trans (2011) 39 (5): 1268–1272.
Published: 21 September 2011
...Lucia Coppo; Pietro Ghezzi Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug...
Articles
Biochem Soc Trans (2011) 39 (5): 1273–1278.
Published: 21 September 2011
...Helen R. Griffiths; Christopher R. Dunston; Stuart J. Bennett; Melissa M. Grant; Darren C. Phillips; George D. Kitas During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell functions. Redox...
Articles
Biochem Soc Trans (2011) 39 (5): 1233–1239.
Published: 21 September 2011
... c.m.spickett@aston.ac.uk ). 24 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 chlorinated phospholipid inflammation mass spectrometry oxidized phospholipid (oxPL) precursor ion scanning Toll-like receptor (TLR) The interest in lipids as mediators...
Articles
Biochem Soc Trans (2011) 39 (4): 886–890.
Published: 20 July 2011
...Hannah Johnston; Herve Boutin; Stuart M. Allan Inflammation has long been proposed as having a role in AD (Alzheimer's disease), although it remains unclear whether inflammation represents a cause or consequence of AD. Evidence from the clinical setting in support of a role for inflammation in AD...
Articles
Biochem Soc Trans (2011) 39 (4): 984–988.
Published: 20 July 2011
... toxicity of LPS aggregates and in a significant increase in LPS-induced mortality as compared with wild-type mice. It suggests that PLTP may play a pivotal role in inflammation and innate immunity through its ability to accelerate the ‘reverse LPS transport’ pathway. 1 To whom correspondence should...
Articles
Biochem Soc Trans (2011) 39 (1): 406–409.
Published: 19 January 2011
... marker inflammation Exoglycosidases are hydrolases involved in post-translational modifications of glycoproteins and degradation of glycoconjugates (glycoproteins, glycolipids and proteoglycans). Post-translational modification of glycoprotein sugar chains occurs in the endoplasmic reticulum...
Articles
Biochem Soc Trans (2010) 38 (5): 1390–1395.
Published: 24 September 2010
... proteins to the intracellular domain of TLR4, initiating the intracellular signal cascade that culminates in translocation of transcription factors to the nucleus and the biosynthesis of cytokines. CD14 inflammation lipid A lipopolysaccharide (LPS) myeloid differentiation protein 2 (MD-2) Toll...
Articles
Biochem Soc Trans (2010) 38 (5): 1342–1348.
Published: 24 September 2010
... to chronic local inflammation that may contribute to the accumulation of drusen and thus the initiation, development and progression of AMD. 1 To whom correspondence should be addressed (email anthony.day@manchester.ac.uk ). 15 3 2010 © The Authors Journal compilation © 2010...
Articles
Biochem Soc Trans (2010) 38 (4): 947–951.
Published: 26 July 2010
...–LF complex was studied thoroughly, and evidence of reciprocal effects of CP and LF was obtained. Another specific interaction investigated in detail occurs between CP and MPO (myeloperoxidase). CP–LF, CP–MPO and CP–LF–MPO complexes were found in sera of patients with inflammation. Modelling in vitro...
Articles
Biochem Soc Trans (2010) 38 (2): 327–330.
Published: 22 March 2010
... 66 9583 9590 30 Virchow R. Aetologie des neoplastichen Geschwulste/Pathogenie der neoplastichen Geschwulste 1863 Berlin Verlag von August Hirschwald 31 Colotta F. Allavena P. Sica A. Garlanda C. Mantovani A. Cancer-related inflammation, the seventh...
Articles
Biochem Soc Trans (2009) 37 (4): 863–867.
Published: 22 July 2009
... Society 2009 cystic fibrosis inflammation lipid A lipopolysaccharide Pseudomonas aeruginosa Toll-like receptor (TLR) CF (cystic fibrosis; OMIM no. 219700) is a lethal autosomal recessive disease found worldwide, but most commonly in Northwest European populations, where the prevalence...
Articles
Biochem Soc Trans (2009) 37 (4): 830–837.
Published: 22 July 2009
...Jane S. Martin; Stephen A. Renshaw Neutrophilic inflammation in the lung protects against infectious disease, and usually resolves spontaneously after removal of the inflammatory stimulus. However, much lung disease is caused by a failure of resolution of neutrophilic inflammation. Our laboratory...
Includes: Multimedia, Supplementary data
Articles
Biochem Soc Trans (2009) 37 (4): 805–810.
Published: 22 July 2009
... contribute to vascular remodelling in lungs after injury or inflammation. Vascular remodelling in the airway is a long recognized component in asthma. Growing numbers of reports suggest that a pro-angiogenic milieu is not a consequence of, but rather dictates the chronic inflammation of asthma. The fairly...
Articles
Biochem Soc Trans (2008) 36 (6): 1211–1215.
Published: 19 November 2008
... and in the negative regulation of inflammation induced via the innate immune response. Furthermore, miR - 146a expression is driven by the transcription factor NF-κB (nuclear factor κB), which has been implicated as an important causal link between inflammation and carcinogenesis. In the present article, we review...