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Keywords: inflammation
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Articles
Biochem Soc Trans (2024) 52 (1): 55–63.
Published: 09 February 2024
... the Creative Commons Attribution License 4.0 (CC BY) . E–S products epigenetics immunomodulation inflammation parasitology Worms are highly successful parasites of both invertebrates and vertebrates and it has been estimated that species transmitted via soil alone may infect in the region...
Articles
Biochem Soc Trans (2023) 51 (6): 2085–2092.
Published: 14 December 2023
... of California in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with UC. HDX-MS inflammation single molecule fret transcription factor The nuclear factor-κB (NF-κB) signaling system involves a family of NF-κB...
Articles
Biochem Soc Trans (2023) 51 (4): 1429–1436.
Published: 14 July 2023
... ( apovo@iib.uam.es ) or Lisardo Boscá ( lbosca@iib.uam.es ) 27 2 2023 29 6 2023 3 7 2023 cell homeostasis fibrosis immunometabolism inflammation macrophages monocytes The essence of the innate immune system has been tightly conserved through evolution. It includes...
Articles
Biochem Soc Trans (2023) 51 (4): 1597–1610.
Published: 14 July 2023
... 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 cytokine signaling Hif1a IFITM3 inflammation innate immunity regulated intramembrane proteolysis In addition to the proteolytic processing of PRRs, γ-secretase plays...
Articles
Biochem Soc Trans (2023) 51 (2): 613–626.
Published: 17 March 2023
... mechanisms, inflammation and/or flow disturbances are major causes of BBB dysfunction in neurological infections and diseases. In particular, in ischaemic stroke, both inflammation and flow disturbances contribute to BBB disruption, leading to devastating consequences. While a transient or minor disruption...
Articles
Biochem Soc Trans (2023) 51 (1): 41–56.
Published: 23 February 2023
... that drives mROS production [ 25 ]. The increased mROS can activate pro-inflammatory signalling pathways [ 31 , 32 ], with this linked to many inflammatory conditions, for example, chronic obstructive pulmonary disease [ 33 ], chronic kidney disease [ 34 ], and type-1 diabetes-associated vascular inflammation...
Articles
Biochem Soc Trans (2023) 51 (1): 223–232.
Published: 06 February 2023
...). Published by Portland Press Limited on behalf of the Biochemical Society 2023 acid-base balance chronic kidney disease gluconeogenesis inflammation lipid metabolism renal physiology Chronic kidney disease (CKD) is clinically defined as reduced kidney function or a structural abnormality...
Articles
Biochem Soc Trans (2023) 51 (1): 303–313.
Published: 25 January 2023
... access for this article was enabled by the participation of University of Queensland in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis inflammation influenza macrophage necroptosis pyroptosis...
Articles
Biochem Soc Trans (2022) 50 (6): 1673–1682.
Published: 23 November 2022
... that express pro-inflammatory and chemotactic effector molecules, stress inducing factors and reactive oxygen species. They control plaque stability and rupture through secretion of metalloproteinases and extracellular matrix degradation. Although macrophages can worsen disease by propagating inflammation...
Articles
Biochem Soc Trans (2022) 50 (5): 1341–1352.
Published: 25 October 2022
... research uncovering evidence of dysfunctional ERK1/2 signalling in inflammatory diseases and discuss the potential therapeutic benefit of targeting ERK1/2 pathways in inflammation. Correspondence: Richard Lucas ( Richard.lucas@imb.uq.edu.au ) 12 6 2022 7 10 2022 10 10 2022 ©...
Articles
Biochem Soc Trans (2022) 50 (2): 799–811.
Published: 28 March 2022
...). Published by Portland Press Limited on behalf of the Biochemical Society 2022 inflammation linear ubiquitination LUBAC LUBAC inhibitors neurodegeneration Ubiquitin is a 76-amino acid protein that is expressed in all eukaryotic cells; it modifies substrate proteins to regulate...
Articles
Biochem Soc Trans (2022) 50 (1): 21–32.
Published: 22 February 2022
...Kristian H. Rasmussen; Clare L. Hawkins Macrophages play an integral role in initiating innate immune defences and regulating inflammation. They are also involved in maintaining homeostasis and the resolution of inflammation, by promoting tissue repair and wound healing. There is evidence that like...
Articles
Biochem Soc Trans (2021) 49 (6): 2495–2507.
Published: 02 December 2021
... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...
Articles
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
...Marina Diotallevi; Faseeha Ayaz; Thomas Nicol; Mark J. Crabtree Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has...
Articles
Biochem Soc Trans (2020) 48 (6): 2525–2537.
Published: 26 November 2020
... BY) . Open access for this article was enabled by the participation of University of Strathclyde in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. inflammation modulators PARs The challenge of targeting...
Articles
Biochem Soc Trans (2020) 48 (1): 1–14.
Published: 12 February 2020
... of the main etiological types of sepsis. Correspondence: Mihai G. Netea ( Mihai.Netea@radboudumc.nl ) 30 10 2019 16 1 2020 20 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 biomarker infection inflammation...
Includes: Supplementary data
Articles
Biochem Soc Trans (2019) 47 (6): 1581–1595.
Published: 26 November 2019
...) . immune cells inflammation LRRK2 Parkinson's disease Rab GTPases The leucine-rich-repeat kinase 2 ( LRRK2 ) gene encodes for a large, multidomain protein encompassing two enzymatic functions at its core. The catalytic core consists of the GTPase domain of the protein, and the serine...
Articles
Biochem Soc Trans (2019) 47 (6): 1921–1930.
Published: 22 November 2019
...Maximilien Euler; Markus H. Hoffmann While there are numerous studies showing that neutrophil extracellular traps (NETs) contribute to autoimmune inflammation and cause bystander tissue injury, human individuals with genetic impairments in NET formation curiously often suffer from exacerbated...
Articles
Biochem Soc Trans (2019) 47 (6): 1679–1687.
Published: 14 November 2019
... fibroblasts inflammation macrophages myocardial infarction Correspondence: Merry L. Lindsey ( Merry.Lindsey@unmc.edu ) 8 9 2019 22 10 2019 24 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 In addition...
Articles
Biochem Soc Trans (2018) 46 (3): 631–639.
Published: 09 May 2018
...Andrew Devitt; Helen R. Griffiths; Ivana Milic Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here, we consider apoptotic cell...
Articles
Biochem Soc Trans (2018) 46 (3): 649–658.
Published: 09 May 2018
...Julia Y. Chu; Barry McCormick; Sonja Vermeren Inflammation is a complex biological response that serves to protect the body's tissues following harmful stimuli such as infection, irritation or injury and initiates tissue repair. At the start of an inflammatory response, pro-inflammatory mediators...
Articles
Biochem Soc Trans (2017) 45 (5): 1105–1115.
Published: 12 September 2017
...Philip C. Calder Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n...
Articles
Biochem Soc Trans (2017) 45 (4): 979–985.
Published: 14 July 2017
...Anna M. Kirwan; Yvonne M. Lenighan; Marcella E. O'Reilly; Fiona C. McGillicuddy; Helen M. Roche Metabolic inflammation is a very topical area of research, wherein aberrations in metabolic and inflammatory pathways probably contribute to atherosclerosis, insulin resistance (IR) and type 2 diabetes...
Articles
Biochem Soc Trans (2017) 45 (4): 999–1006.
Published: 14 July 2017
...Jonas Franz; Marco Tarantola; Christoph Riethmüller Tetraspanins are ubiquitous membrane proteins that induce local membrane curvature and hence co-ordinate cell-to-cell contacts. This review highlights their role in inflammation, which requires control of the nano-architecture of attachment sites...
Articles
Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
.... Thus, it is not surprising that lncRNAs have emerged as important players in human pathophysiology. As our body's first line of defense upon infection or injury, inflammation has been implicated in the etiology of several human diseases. At the center of the acute inflammatory response, as well...
Articles
Biochem Soc Trans (2016) 44 (6): 1581–1602.
Published: 02 December 2016
... that drive transcription of genes involved in the orchestration of inflammation. These transcription factors regulate a variety of immune responses through expression of cytokines, chemokines and pro-inflammatory and survival genes (reviewed in ref. [ 21 ]). Aberrant inflammatory signalling is the cause...
Articles
Biochem Soc Trans (2016) 44 (4): 1101–1110.
Published: 15 August 2016
... information to enable adaptability, is central to this whole process. Critically, hormesis could improve mitochondrial quantum efficiency, improving the ATP/ROS ratio, whereas inflammation, which is tightly associated with the aging process, might do the opposite. This all suggests that to achieve optimal...
Articles
Biochem Soc Trans (2015) 43 (6): 1247–1252.
Published: 27 November 2015
... and plays a role in suppressing inflammation. Similar to 4E-BP, eIF4E activity is also regulated by phosphorylation by several kinases, e.g. mTOR [ 27 ]. The specificity of eIF4E for 5′TOP mRNAs is phosphorylation-dependent [ 27 – 29 ], although the exact mechanism of activating the innate immune...
Articles
Biochem Soc Trans (2015) 43 (5): 1051–1056.
Published: 09 October 2015
... pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation...
Articles
Biochem Soc Trans (2015) 43 (4): 740–744.
Published: 03 August 2015
... of the microenvironment. Macrophage activation can be classified as pro-inflammatory (M1 polarization) or anti-inflammatory-pro-resolution-deactivation (M2), these profiles coexisting in the course of the immune response and playing a relevant functional role in the onset of inflammation (Figure 1). Several groups have...
Articles
Biochem Soc Trans (2015) 43 (4): 727–733.
Published: 03 August 2015
..., metabolism and nutrient absorption are well studied; but their potential interactions with the enriched numbers of surrounding immune cells remain largely unexplored. This review focuses on alterations in enteroendocrine cell number and peptide secretion during inflammation and disease, highlighting the few...
Articles
Biochem Soc Trans (2015) 43 (4): 691–695.
Published: 03 August 2015
... prestonr@tcd.ie ) . 12 12 2014 © 2015 Authors; published by Portland Press Limited 2015 activated protein C anti-coagulant inflammation protease-activated receptor 1 sepsis When vascular injury occurs, a prompt response is required to stem blood loss. This is achieved...
Articles
Articles
Biochem Soc Trans (2014) 42 (6): 1490–1497.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 chemokine receptor inflammation lymphocyte function-associated antigen 1 (LFA-1) migration protein kinase C T-cell The ability of T-cells to migrate to various organs and tissues throughout the body is crucial for immune responses to pathogens...
Articles
Biochem Soc Trans (2014) 42 (5): 1321–1325.
Published: 18 September 2014
... death and cognitive and behavioural deficits. Neuroinflammation is also a prominent feature of AD brain and considerable evidence indicates that inflammatory events play a significant role in modulating the progression of AD. The role of microglia in AD inflammation has long been acknowledged...
Articles
Biochem Soc Trans (2014) 42 (5): 1316–1320.
Published: 18 September 2014
... elusive, as they seem to adopt different functions dependent on disease progression and the extent of accompanying parenchymal inflammation. Astrocytes may contribute to the clearance of amyloid β-peptide (Aβ) and restrict the spread of inflammation in the brain. Conversely, they may contribute...
Articles
Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
... in aging and in the pathogenesis of diseases such as inflammation, diabetes and cancer. Since superoxide formation, in particular in mitochondria, is often considered to be an initial step in the pathogenesis of these diseases, improper function of the MnSOD (mitochondrial superoxide dismutase; SOD2) may...
Articles
Biochem Soc Trans (2014) 42 (2): 244–249.
Published: 20 March 2014
... specific roles in several tissues, among which are the regulation of energy expenditure, GLP-1 (glucagon-like peptide 1) secretion and gall bladder filling. An accumulating body of evidence now demonstrates that TGR5 also acts in a number of processes important in inflammation. Most striking...
Articles
Biochem Soc Trans (2014) 42 (2): 538–542.
Published: 20 March 2014
...Usman Ahmed; Paul J. Thornalley; Naila Rabbani OA (osteoarthritis) and RA (rheumatoid arthritis) lead to deterioration of the joints. Early OA is associated with loss of bone due to increased bone remodelling. A role for inflammation is thought to be integral to the pathology. RA is a chronic...
Articles
Biochem Soc Trans (2014) 42 (2): 284–288.
Published: 20 March 2014
...), are mediators of chronic inflammation during atherogenesis. Subsequently, disruption of these organelles is associated with a broad range of disease states including cardiovascular disease and cancer. Cavin-1 is an essential peripheral component of caveolae that stabilizes caveolin-1, the main structural...
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Articles
Biochem Soc Trans (2014) 42 (1): 59–62.
Published: 23 January 2014
... (ERK) inflammation interleukin 6-type cytokine Janus kinase (JAK) signal transducer and activator of transcription (STAT) IL (interleukin)-6-type cytokines are critical molecules that determine health and disease in many living organisms (reviewed in [ 1 , 2 ]). The IL-6 family of cytokines...
Articles
Biochem Soc Trans (2013) 41 (2): 687–693.
Published: 21 March 2013
... and is required for the switch from glycolysis (fermentation) to oxidative metabolism when glucose runs low. In mammals, rapidly proliferating cells (including tumour cells) and immune cells involved in inflammation both tend to utilize rapid glucose uptake and glycolysis (termed the Warburg effect or aerobic...
Articles
Biochem Soc Trans (2012) 40 (1): 133–138.
Published: 19 January 2012
...David C. Clarke; Douglas A. Lauffenburger Inflammation is a key physiological response to infection and injury and, although usually beneficial, it can also be damaging to the host. The liver is a prototypical example in this regard because inflammation helps to resolve liver injury, but it also...
Articles
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... unrelated to hypoxia or inflammation [ 19 ], although when we hyperperfused resting canine muscle to the same levels as seen during stimulated contractions (that were sufficiently intense to increase muscle VEGF mRNA), there was no increase in muscle VEGF mRNA [ 20 ]. One interesting question is which...
Articles
Biochem Soc Trans (2011) 39 (6): 1619–1627.
Published: 21 November 2011
...Wenda Ramma; Asif Ahmed It has been proposed that either excessive inflammation or an imbalance in angiogenic factors cause pre-eclampsia. In the present review, the arguments for and against the role of inflammation and/or angiogenic imbalance as the cause of pre-eclampsia are discussed...
Articles
Biochem Soc Trans (2011) 39 (5): 1233–1239.
Published: 21 September 2011
... c.m.spickett@aston.ac.uk ). 24 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 chlorinated phospholipid inflammation mass spectrometry oxidized phospholipid (oxPL) precursor ion scanning Toll-like receptor (TLR) The interest in lipids as mediators...
Articles
Biochem Soc Trans (2011) 39 (5): 1268–1272.
Published: 21 September 2011
...Lucia Coppo; Pietro Ghezzi Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug...
Articles
Biochem Soc Trans (2011) 39 (5): 1273–1278.
Published: 21 September 2011
...Helen R. Griffiths; Christopher R. Dunston; Stuart J. Bennett; Melissa M. Grant; Darren C. Phillips; George D. Kitas During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell functions. Redox...
Articles
Biochem Soc Trans (2011) 39 (4): 886–890.
Published: 20 July 2011
...Hannah Johnston; Herve Boutin; Stuart M. Allan Inflammation has long been proposed as having a role in AD (Alzheimer's disease), although it remains unclear whether inflammation represents a cause or consequence of AD. Evidence from the clinical setting in support of a role for inflammation in AD...