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Articles

The role of the blood–brain barrier during neurological disease and infection

Adjanie Patabendige, Damir Janigro

Biochem Soc Trans (2023) 51 (2): 613–626.

DOI: https://doi.org/10.1042/BST20220830

Published: 17 March 2023

... mechanisms, inflammation and/or flow disturbances are major causes of BBB dysfunction in neurological infections and diseases. In particular, in ischaemic stroke, both inflammation and flow disturbances contribute to BBB disruption, leading to devastating consequences. While a transient or minor disruption...

View article titled, The role of the blood–brain barrier during neurological disease and infection

Articles

Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?

Syeda Farhana Afroz, Karoline D. Raven, Grace M.E.P. Lawrence, Ronan Kapetanovic, Kate Schroder, Matthew J. Sweet

Biochem Soc Trans (2023) 51 (1): 41–56.

DOI: https://doi.org/10.1042/BST20220014

Published: 23 February 2023

... of the University of Queensland in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. inflammation macrophages mitochondrial dynamics mitochondrial fission mitochondrial fusion neuroinflammation Macrophages...

View article titled, Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?

Articles

The mechanisms of alkali therapy in targeting renal diseases

Pedro Henrique Imenez Silva, Donald E. Wesson, Carsten A. Wagner

Biochem Soc Trans (2023) 51 (1): 223–232.

DOI: https://doi.org/10.1042/BST20220690

Published: 06 February 2023

...) that binds HCl in the gastrointestinal lumen that is undergoing testing as a treatment for metabolic acidosis [ 5 , 6 ]. acid-base balance chronic kidney disease gluconeogenesis inflammation lipid metabolism renal physiology © 2023 The Author(s). Published by Portland Press Limited...

View article titled, The mechanisms of alkali therapy in targeting renal diseases

Articles

Inflammatory cell death: how macrophages sense neighbouring cell infection and damage

Xiaohui Wang, Larisa I. Labzin

Biochem Soc Trans (2023) 51 (1): 303–313.

DOI: https://doi.org/10.1042/BST20220807

Published: 25 January 2023

... access for this article was enabled by the participation of University of Queensland in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. apoptosis inflammation influenza macrophage necroptosis pyroptosis...

View article titled, Inflammatory cell death: how macrophages sense neighbouring cell infection and damage

Articles

The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

Heather M. Wilson

Biochem Soc Trans (2022) 50 (6): 1673–1682.

DOI: https://doi.org/10.1042/BST20220441

Published: 23 November 2022

... that express pro-inflammatory and chemotactic effector molecules, stress inducing factors and reactive oxygen species. They control plaque stability and rupture through secretion of metalloproteinases and extracellular matrix degradation. Although macrophages can worsen disease by propagating inflammation...

View article titled, The intracellular signaling pathways governing macrophage activation and function in human atherosclerosis

Articles

ERK1/2 in immune signalling

Richard M. Lucas, Lin Luo, Jennifer L. Stow

Biochem Soc Trans (2022) 50 (5): 1341–1352.

DOI: https://doi.org/10.1042/BST20220271

Published: 25 October 2022

... research uncovering evidence of dysfunctional ERK1/2 signalling in inflammatory diseases and discuss the potential therapeutic benefit of targeting ERK1/2 pathways in inflammation. Correspondence: Richard Lucas ( Richard.lucas@imb.uq.edu.au ) 12 6 2022 7 10 2022 10 10 2022 ©...

View article titled, ERK1/2 in immune signalling

Articles

Linear ubiquitination in immune and neurodegenerative diseases, and beyond

In Collection

Cell death and survival

Fuminori Tokunaga, Fumiyo Ikeda

Biochem Soc Trans (2022) 50 (2): 799–811.

DOI: https://doi.org/10.1042/BST20211078

Published: 28 March 2022

...). Published by Portland Press Limited on behalf of the Biochemical Society 2022 inflammation linear ubiquitination LUBAC LUBAC inhibitors neurodegeneration Ubiquitin is a 76-amino acid protein that is expressed in all eukaryotic cells; it modifies substrate proteins to regulate...

View article titled, Linear ubiquitination in immune and neurodegenerative diseases, and beyond

Articles

Role of macrophage extracellular traps in innate immunity and inflammatory disease

In Collection

Cell death and survival

Kristian H. Rasmussen, Clare L. Hawkins

Biochem Soc Trans (2022) 50 (1): 21–32.

DOI: https://doi.org/10.1042/BST20210962

Published: 22 February 2022

...Kristian H. Rasmussen; Clare L. Hawkins Macrophages play an integral role in initiating innate immune defences and regulating inflammation. They are also involved in maintaining homeostasis and the resolution of inflammation, by promoting tissue repair and wound healing. There is evidence that like...

View article titled, Role of macrophage extracellular traps in innate immunity and inflammatory disease

Articles

PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling

In Collection

Cell death and survival

Chloe M. McKee, Fabian A. Fischer, Jelena S. Bezbradica, Rebecca C. Coll

Biochem Soc Trans (2021) 49 (6): 2495–2507.

DOI: https://doi.org/10.1042/BST20200987

Published: 02 December 2021

... minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of inflammatory diseases. Phosphorylation is a fundamental post-translational modification that allows rapid control over protein function and the phosphorylation of inflammasome...

View article titled, PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling

Articles

Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine

Marina Diotallevi, Faseeha Ayaz, Thomas Nicol, Mark J. Crabtree

Biochem Soc Trans (2021) 49 (5): 2189–2198.

DOI: https://doi.org/10.1042/BST20210269

Published: 19 October 2021

...Marina Diotallevi; Faseeha Ayaz; Thomas Nicol; Mark J. Crabtree Inflammation is a critical component of cardiovascular disease (CVD), encompassing coronary artery disease (CAD), cerebrovascular events and heart failure and is the leading cause of mortality worldwide. In recent years, metabolism has...

View article titled, Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine

Articles

The development of proteinase-activated receptor-2 modulators and the challenges involved

Kathryn A. McIntosh, Margaret R. Cunningham, Trevor Bushell, Robin Plevin

Biochem Soc Trans (2020) 48 (6): 2525–2537.

DOI: https://doi.org/10.1042/BST20200191

Published: 26 November 2020

... BY) . Open access for this article was enabled by the participation of University of Strathclyde in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. inflammation modulators PARs The challenge of targeting...

View article titled, The development of proteinase-activated receptor-2 modulators and the challenges involved

Articles

Biomarkers of inflammation and the etiology of sepsis

Inge Grondman, Andrei Pirvu, Anca Riza, Mihai Ioana, Mihai G. Netea

Biochem Soc Trans (2020) 48 (1): 1–14.

DOI: https://doi.org/10.1042/BST20190029

Published: 12 February 2020

... of the main etiological types of sepsis. Correspondence: Mihai G. Netea ( Mihai.Netea@radboudumc.nl ) 30 10 2019 16 1 2020 20 1 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 biomarker infection inflammation...

View article titled, Biomarkers of inflammation and the etiology of sepsis

Includes: Supplementary data

Articles

LRRK2 regulation of immune-pathways and inflammatory disease

Rebecca L. Wallings, Malú G. Tansey

Biochem Soc Trans (2019) 47 (6): 1581–1595.

DOI: https://doi.org/10.1042/BST20180463

Published: 26 November 2019

... R1441G Increased pro-inflammatory cytokines in the periphery and increase CNS inflammation and neurodegeneration in response to LPS [ 17 ] HUVECs G2019S (GoF) K1347A (KD) Increased VCAM-1 expression in GS in response to IL-1β [ 12 ] Microglia Lrrk2 KO Increased α-synuclein uptake...

View article titled, LRRK2 regulation of immune-pathways and inflammatory disease

Articles

The double-edged role of neutrophil extracellular traps in inflammation

Maximilien Euler, Markus H. Hoffmann

Biochem Soc Trans (2019) 47 (6): 1921–1930.

DOI: https://doi.org/10.1042/BST20190629

Published: 22 November 2019

...Maximilien Euler; Markus H. Hoffmann While there are numerous studies showing that neutrophil extracellular traps (NETs) contribute to autoimmune inflammation and cause bystander tissue injury, human individuals with genetic impairments in NET formation curiously often suffer from exacerbated...

View article titled, The double-edged role of neutrophil extracellular traps in inflammation

Articles

Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium

Mavis A.A. Tenkorang, Upendra Chalise, Michael J. Daseke, II, Shelby R. Konfrst, Merry L. Lindsey

Biochem Soc Trans (2019) 47 (6): 1679–1687.

DOI: https://doi.org/10.1042/BST20190113

Published: 14 November 2019

..., anti-inflammation begins the wound healing phase. Neutrophils, macrophages, and fibroblasts regulate this shift by changing their own polarization phenotypes [ 8 , 10 , 11 ]. Towards the end of the inflammatory phase heading into day 3, neutrophils begin to undergo apoptosis. Apoptotic neutrophils...

View article titled, Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium

Articles

Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation

Julia Y. Chu, Barry McCormick, Sonja Vermeren

Biochem Soc Trans (2018) 46 (3): 649–658.

DOI: https://doi.org/10.1042/BST20170530

Published: 09 May 2018

...Julia Y. Chu; Barry McCormick; Sonja Vermeren Inflammation is a complex biological response that serves to protect the body's tissues following harmful stimuli such as infection, irritation or injury and initiates tissue repair. At the start of an inflammatory response, pro-inflammatory mediators...

View article titled, Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation

Articles

Communicating with the dead: lipids, lipid mediators and extracellular vesicles

Andrew Devitt, Helen R. Griffiths, Ivana Milic

Biochem Soc Trans (2018) 46 (3): 631–639.

DOI: https://doi.org/10.1042/BST20160477

Published: 09 May 2018

...Andrew Devitt; Helen R. Griffiths; Ivana Milic Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here, we consider apoptotic cell...

View article titled, Communicating with the dead: lipids, lipid mediators and extracellular vesicles

Articles

Omega-3 fatty acids and inflammatory processes: from molecules to man

Philip C. Calder

Biochem Soc Trans (2017) 45 (5): 1105–1115.

DOI: https://doi.org/10.1042/BST20160474

Published: 12 September 2017

...Philip C. Calder Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n...

View article titled, Omega-3 fatty acids and inflammatory processes: from molecules to man

Articles

Nutritional modulation of metabolic inflammation

Anna M. Kirwan, Yvonne M. Lenighan, Marcella E. O'Reilly, Fiona C. McGillicuddy, Helen M. Roche

Biochem Soc Trans (2017) 45 (4): 979–985.

DOI: https://doi.org/10.1042/BST20160465

Published: 14 July 2017

...Anna M. Kirwan; Yvonne M. Lenighan; Marcella E. O'Reilly; Fiona C. McGillicuddy; Helen M. Roche Metabolic inflammation is a very topical area of research, wherein aberrations in metabolic and inflammatory pathways probably contribute to atherosclerosis, insulin resistance (IR) and type 2 diabetes...

View article titled, Nutritional modulation of metabolic inflammation

Articles

How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation

Jonas Franz, Marco Tarantola, Christoph Riethmüller

Biochem Soc Trans (2017) 45 (4): 999–1006.

DOI: https://doi.org/10.1042/BST20170163

Published: 14 July 2017

...Jonas Franz; Marco Tarantola; Christoph Riethmüller Tetraspanins are ubiquitous membrane proteins that induce local membrane curvature and hence co-ordinate cell-to-cell contacts. This review highlights their role in inflammation, which requires control of the nano-architecture of attachment sites...

View article titled, How tetraspanins shape endothelial and leukocyte nano-architecture during inflammation

Articles

Lnc-ing inflammation to disease

Loretta Magagula, Maria Gagliardi, Jerolen Naidoo, Musa Mhlanga

Biochem Soc Trans (2017) 45 (4): 953–962.

DOI: https://doi.org/10.1042/BST20160377

Published: 07 July 2017

.... Thus, it is not surprising that lncRNAs have emerged as important players in human pathophysiology. As our body's first line of defense upon infection or injury, inflammation has been implicated in the etiology of several human diseases. At the center of the acute inflammatory response, as well...

View article titled, Lnc-ing inflammation to disease

Articles

Molecular basis for specificity of the Met1-linked polyubiquitin signal

Paul R. Elliott

Biochem Soc Trans (2016) 44 (6): 1581–1602.

DOI: https://doi.org/10.1042/BST20160227

Published: 02 December 2016

... Attribution License 4.0 (CC BY) . inflammation post-translational modification ubiquitin signalling Post-translational modification of proteins is one mechanism by which signalling cascades, such as those activating nuclear factor-κB (NF-κB) and mitogen-activated protein kinases, are regulated...

View article titled, Molecular basis for specificity of the Met1-linked polyubiquitin signal

Articles

The quantum mitochondrion and optimal health

Alistair V.W. Nunn, Geoffrey W. Guy, Jimmy D. Bell

Biochem Soc Trans (2016) 44 (4): 1101–1110.

DOI: https://doi.org/10.1042/BST20160096

Published: 15 August 2016

... information to enable adaptability, is central to this whole process. Critically, hormesis could improve mitochondrial quantum efficiency, improving the ATP/ROS ratio, whereas inflammation, which is tightly associated with the aging process, might do the opposite. This all suggests that to achieve optimal...

View article titled, The quantum mitochondrion and optimal health

Articles

Tuning innate immunity by translation

Robert Rauscher, Zoya Ignatova

Biochem Soc Trans (2015) 43 (6): 1247–1252.

DOI: https://doi.org/10.1042/BST20150166

Published: 27 November 2015

... by Portland Press Limited 2015 infection inflammation interferons interleukins translation translation initiation Adequate reprogramming of metabolic activities under environmental stress is crucial for cell survival. Regulation at the level of translation provides the necessary plasticity...

View article titled, Tuning innate immunity by translation

Articles

Tribbles and arthritis: what are the links?

Andrew D. Rowan, Gary J. Litherland

Biochem Soc Trans (2015) 43 (5): 1051–1056.

DOI: https://doi.org/10.1042/BST20150076

Published: 09 October 2015

... pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation...

View article titled, Tribbles and arthritis: what are the links?

Articles

Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation

Lisardo Boscá, Silvia González-Ramos, Patricia Prieto, María Fernández-Velasco, Marina Mojena, Paloma Martín-Sanz, Susana Alemany

Biochem Soc Trans (2015) 43 (4): 740–744.

DOI: https://doi.org/10.1042/BST20150107

Published: 03 August 2015

... of the microenvironment. Macrophage activation can be classified as pro-inflammatory (M1 polarization) or anti-inflammatory-pro-resolution-deactivation (M2), these profiles coexisting in the course of the immune response and playing a relevant functional role in the onset of inflammation (Figure 1). Several groups have...

View article titled, Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation

Articles

The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease

John J Worthington

Biochem Soc Trans (2015) 43 (4): 727–733.

DOI: https://doi.org/10.1042/BST20150090

Published: 03 August 2015

..., metabolism and nutrient absorption are well studied; but their potential interactions with the enriched numbers of surrounding immune cells remain largely unexplored. This review focuses on alterations in enteroendocrine cell number and peptide secretion during inflammation and disease, highlighting the few...

View article titled, The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease

Articles

Engineering activated protein C to maximize therapeutic efficacy

Louise M. Quinn, Clive Drakeford, James S. O’Donnell, Roger J.S. Preston

Biochem Soc Trans (2015) 43 (4): 691–695.

DOI: https://doi.org/10.1042/BST20140312

Published: 03 August 2015

... prestonr@tcd.ie ) . 12 12 2014 © 2015 Authors; published by Portland Press Limited 2015 activated protein C anti-coagulant inflammation protease-activated receptor 1 sepsis When vascular injury occurs, a prompt response is required to stem blood loss. This is achieved...

View article titled, Engineering activated protein C to maximize therapeutic efficacy

Articles

Immunoglobulin heavy-chain-binding protein (BiP): a stress protein that has the potential to be a novel therapy for rheumatoid arthritis

Gabriel S. Panayi, Valerie M. Corrigall

Biochem Soc Trans (2014) 42 (6): 1752–1755.

DOI: https://doi.org/10.1042/BST20140230

Published: 17 November 2014

... receptor antagonist and soluble tumour necrosis factor (TNF)-receptor type II, and attenuation of TNFα and IL-6. Together, these functions help drive the resolution of inflammation. Disease models of inflammatory arthritis have helped to demonstrate the novel mode of action of BiP in which...

View article titled, Immunoglobulin heavy-chain-binding protein (BiP): a stress protein that has the potential to be a novel therapy for rheumatoid arthritis

Articles

Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration

Aideen Long, Michael Freeley

Biochem Soc Trans (2014) 42 (6): 1490–1497.

DOI: https://doi.org/10.1042/BST20140204

Published: 17 November 2014

... compilation © 2014 Biochemical Society 2014 chemokine receptor inflammation lymphocyte function-associated antigen 1 (LFA-1) migration protein kinase C T-cell The ability of T-cells to migrate to various organs and tissues throughout the body is crucial for immune responses to pathogens...

View article titled, Protein kinase C: a regulator of cytoskeleton remodelling and T-cell migration

Articles

Astrocytes and neuroinflammation in Alzheimer's disease

Emma C. Phillips, Cara L. Croft, Ksenia Kurbatskaya, Michael J. O’Neill, Michael L. Hutton, Diane P. Hanger, Claire J. Garwood, Wendy Noble

Biochem Soc Trans (2014) 42 (5): 1321–1325.

DOI: https://doi.org/10.1042/BST20140155

Published: 18 September 2014

... death and cognitive and behavioural deficits. Neuroinflammation is also a prominent feature of AD brain and considerable evidence indicates that inflammatory events play a significant role in modulating the progression of AD. The role of microglia in AD inflammation has long been acknowledged...

View article titled, Astrocytes and neuroinflammation in Alzheimer's disease

Articles

The contribution of astrocytes to Alzheimer's disease

Amy M. Birch

Biochem Soc Trans (2014) 42 (5): 1316–1320.

DOI: https://doi.org/10.1042/BST20140171

Published: 18 September 2014

... elusive, as they seem to adopt different functions dependent on disease progression and the extent of accompanying parenchymal inflammation. Astrocytes may contribute to the clearance of amyloid β-peptide (Aβ) and restrict the spread of inflammation in the brain. Conversely, they may contribute...

View article titled, The contribution of astrocytes to Alzheimer's disease

Articles

Manganese superoxide dismutase in carcinogenesis: friend or foe?

Anja Konzack, Thomas Kietzmann

Biochem Soc Trans (2014) 42 (4): 1012–1016.

DOI: https://doi.org/10.1042/BST20140076

Published: 11 August 2014

... in aging and in the pathogenesis of diseases such as inflammation, diabetes and cancer. Since superoxide formation, in particular in mitochondria, is often considered to be an initial step in the pathogenesis of these diseases, improper function of the MnSOD (mitochondrial superoxide dismutase; SOD2) may...

View article titled, Manganese superoxide dismutase in carcinogenesis: friend or foe?

Articles

Cavin-1: caveolae-dependent signalling and cardiovascular disease

Jamie J.L. Williams, Timothy M. Palmer

Biochem Soc Trans (2014) 42 (2): 284–288.

DOI: https://doi.org/10.1042/BST20130270

Published: 20 March 2014

...), are mediators of chronic inflammation during atherogenesis. Subsequently, disruption of these organelles is associated with a broad range of disease states including cardiovascular disease and cancer. Cavin-1 is an essential peripheral component of caveolae that stabilizes caveolin-1, the main structural...

View article titled, Cavin-1: caveolae-dependent signalling and cardiovascular disease

Articles

TGR5 in inflammation and cardiovascular disease

Thijs W.H. Pols

Biochem Soc Trans (2014) 42 (2): 244–249.

DOI: https://doi.org/10.1042/BST20130279

Published: 20 March 2014

... specific roles in several tissues, among which are the regulation of energy expenditure, GLP-1 (glucagon-like peptide 1) secretion and gall bladder filling. An accumulating body of evidence now demonstrates that TGR5 also acts in a number of processes important in inflammation. Most striking...

View article titled, TGR5 in inflammation and cardiovascular disease

Articles

Possible role of methylglyoxal and glyoxalase in arthritis

Usman Ahmed, Paul J. Thornalley, Naila Rabbani

Biochem Soc Trans (2014) 42 (2): 538–542.

DOI: https://doi.org/10.1042/BST20140024

Published: 20 March 2014

...Usman Ahmed; Paul J. Thornalley; Naila Rabbani OA (osteoarthritis) and RA (rheumatoid arthritis) lead to deterioration of the joints. Early OA is associated with loss of bone due to increased bone remodelling. A role for inflammation is thought to be integral to the pathology. RA is a chronic...

View article titled, Possible role of methylglyoxal and glyoxalase in arthritis

Articles

Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

Belinda Hall, Rachel Simmonds

Biochem Soc Trans (2014) 42 (1): 177–183.

DOI: https://doi.org/10.1042/BST20130133

Published: 23 January 2014

... to identify commonalities between the different functional and cellular systems. Since mycolactone influences fundamental cellular processes (cell division, cell death and inflammation), getting to the root of how mycolactone achieves this could have a profound impact on our understanding of eukaryotic cell...

View article titled, Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

Articles

Regulation of IL-6-type cytokine responses by MAPKs

Ana P. Costa-Pereira

Biochem Soc Trans (2014) 42 (1): 59–62.

DOI: https://doi.org/10.1042/BST20130267

Published: 23 January 2014

... (ERK) inflammation interleukin 6-type cytokine Janus kinase (JAK) signal transducer and activator of transcription (STAT) IL (interleukin)-6-type cytokines are critical molecules that determine health and disease in many living organisms (reviewed in [ 1 , 2 ]). The IL-6 family of cytokines...

View article titled, Regulation of IL-6-type cytokine responses by MAPKs

Articles

AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

Madhumita Dandapani, D. Grahame Hardie

Biochem Soc Trans (2013) 41 (2): 687–693.

DOI: https://doi.org/10.1042/BST20120351

Published: 21 March 2013

... and is required for the switch from glycolysis (fermentation) to oxidative metabolism when glucose runs low. In mammals, rapidly proliferating cells (including tumour cells) and immune cells involved in inflammation both tend to utilize rapid glucose uptake and glycolysis (termed the Warburg effect or aerobic...

View article titled, AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?

Articles

Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments

David C. Clarke, Douglas A. Lauffenburger

Biochem Soc Trans (2012) 40 (1): 133–138.

DOI: https://doi.org/10.1042/BST20110633

Published: 19 January 2012

...David C. Clarke; Douglas A. Lauffenburger Inflammation is a key physiological response to infection and injury and, although usually beneficial, it can also be damaging to the host. The liver is a prototypical example in this regard because inflammation helps to resolve liver injury, but it also...

View article titled, Multi-pathway network analysis of mammalian epithelial cell responses in inflammatory environments

Articles

Is inflammation the cause of pre-eclampsia?

Wenda Ramma, Asif Ahmed

Biochem Soc Trans (2011) 39 (6): 1619–1627.

DOI: https://doi.org/10.1042/BST20110672

Published: 21 November 2011

...Wenda Ramma; Asif Ahmed It has been proposed that either excessive inflammation or an imbalance in angiogenic factors cause pre-eclampsia. In the present review, the arguments for and against the role of inflammation and/or angiogenic imbalance as the cause of pre-eclampsia are discussed...

View article titled, Is inflammation the cause of pre-eclampsia?

Articles

The critical role of VEGF in skeletal muscle angiogenesis and blood flow

Peter D. Wagner

Biochem Soc Trans (2011) 39 (6): 1556–1559.

DOI: https://doi.org/10.1042/BST20110646

Published: 21 November 2011

... falling to single digit values during exercise, muscle-specific HIF knockout does not impair performance or capillarity, leaving many unanswered questions. © The Authors Journal compilation © 2011 Biochemical Society 2011 exercise hypoxia hypoxia-inducible factor (HIF) inflammation vascular...

View article titled, The critical role of VEGF in skeletal muscle angiogenesis and blood flow

Articles

Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism

Lucia Coppo, Pietro Ghezzi

Biochem Soc Trans (2011) 39 (5): 1268–1272.

DOI: https://doi.org/10.1042/BST0391268

Published: 21 September 2011

...Lucia Coppo; Pietro Ghezzi Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug...

View article titled, Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism

Articles

Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Helen R. Griffiths, Christopher R. Dunston, Stuart J. Bennett, Melissa M. Grant, Darren C. Phillips, George D. Kitas

Biochem Soc Trans (2011) 39 (5): 1273–1278.

DOI: https://doi.org/10.1042/BST0391273

Published: 21 September 2011

...Helen R. Griffiths; Christopher R. Dunston; Stuart J. Bennett; Melissa M. Grant; Darren C. Phillips; George D. Kitas During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell functions. Redox...

View article titled, Free radicals and redox signalling in T-cells during chronic inflammation and ageing

Articles

Analysis of oxidized and chlorinated lipids by mass spectrometry and relevance to signalling

Corinne M. Spickett, Norsyahida Mohd Fauzi

Biochem Soc Trans (2011) 39 (5): 1233–1239.

DOI: https://doi.org/10.1042/BST0391233

Published: 21 September 2011

... c.m.spickett@aston.ac.uk ). 24 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 chlorinated phospholipid inflammation mass spectrometry oxidized phospholipid (oxPL) precursor ion scanning Toll-like receptor (TLR) The interest in lipids as mediators...

View article titled, Analysis of oxidized and chlorinated lipids by mass spectrometry and relevance to signalling

Articles

Assessing the contribution of inflammation in models of Alzheimer's disease

Hannah Johnston, Herve Boutin, Stuart M. Allan

Biochem Soc Trans (2011) 39 (4): 886–890.

DOI: https://doi.org/10.1042/BST0390886

Published: 20 July 2011

...Hannah Johnston; Herve Boutin; Stuart M. Allan Inflammation has long been proposed as having a role in AD (Alzheimer's disease), although it remains unclear whether inflammation represents a cause or consequence of AD. Evidence from the clinical setting in support of a role for inflammation in AD...

View article titled, Assessing the contribution of inflammation in models of Alzheimer's disease

Articles

Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’ and innate immunity

Thomas Gautier, Laurent Lagrost

Biochem Soc Trans (2011) 39 (4): 984–988.

DOI: https://doi.org/10.1042/BST0390984

Published: 20 July 2011

... toxicity of LPS aggregates and in a significant increase in LPS-induced mortality as compared with wild-type mice. It suggests that PLTP may play a pivotal role in inflammation and innate immunity through its ability to accelerate the ‘reverse LPS transport’ pathway. Thus an important question is to know...

View article titled, Plasma PLTP (phospholipid-transfer protein): an emerging role in ‘reverse lipopolysaccharide transport’ and innate immunity

Articles

Exoglycosidase markers of diseases

Sylwia Chojnowska, Alina Kępka, Sławomir Dariusz Szajda, Napoleon Waszkiewicz, Marcin Bierć, Krzysztof Zwierz

Biochem Soc Trans (2011) 39 (1): 406–409.

DOI: https://doi.org/10.1042/BST0390406

Published: 19 January 2011

... ] and degradative [ 1 ] processes. 1 To whom correspondence should be addressed (email kzwie@umwb.edu.pl ). 7 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 alcoholism cancer exoglycosidase marker inflammation Exoglycosidases are hydrolases...

View article titled, Exoglycosidase markers of diseases

Articles

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology

Simon J. Clark, Paul N. Bishop, Anthony J. Day

Biochem Soc Trans (2010) 38 (5): 1342–1348.

DOI: https://doi.org/10.1042/BST0381342

Published: 24 September 2010

... to chronic local inflammation that may contribute to the accumulation of drusen and thus the initiation, development and progression of AMD. CRP is an acute-phase protein, in that its concentration in blood rises dramatically during inflammation, e.g. it is increased in the circulation and choroid...

View article titled, Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology

Articles

Exploring the LPS/TLR4 signal pathway with small molecules

Francesco Peri, Matteo Piazza, Valentina Calabrese, Gaetana Damore, Roberto Cighetti

Biochem Soc Trans (2010) 38 (5): 1390–1395.

DOI: https://doi.org/10.1042/BST0381390

Published: 24 September 2010

... proteins to the intracellular domain of TLR4, initiating the intracellular signal cascade that culminates in translocation of transcription factors to the nucleus and the biosynthesis of cytokines. CD14 inflammation lipid A lipopolysaccharide (LPS) myeloid differentiation protein 2 (MD-2...

View article titled, Exploring the LPS/TLR4 signal pathway with small molecules

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