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Keywords: inflammasome
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Biochem Soc Trans (2023) 51 (4): 1621–1633.
Published: 03 August 2023
.... While several studies describe their mechanistic role in the lysis of bacteria/pathogen vacuole, and activation of the inflammasome, their functions in viral infections are only just emerging. The role of the GBPs in virus infections is multifaceted, being both dependent on and independent of GTP...
Biochem Soc Trans (2021) 49 (6): 2601–2610.
Published: 02 December 2021
... also being implicated in gut pathologies, such as colitis and colorectal cancer (CRC). Here, we discuss the current literature focusing on NLR family apoptosis inhibitory proteins (NAIPs) and other NLRs that have non-inflammasome roles in the gut. The mechanisms behind NLR-mediated protection often...
Biochem Soc Trans (2021) 49 (6): 2697–2710.
Published: 23 November 2021
...Ayesha Zahid; Hazrat Ismail; Tengchuan Jin Pyroptosis is a highly inflammatory and lytic type of programmed cell death (PCD) commenced by inflammasomes, which sense perturbations in the cytosolic environment. Recently, several ground-breaking studies have linked a family of pore-forming proteins...
Biochem Soc Trans (2021) 49 (3): 1311–1324.
Published: 01 June 2021
...Georgia Bateman; Benjamin Hill; Ryan Knight; Dave Boucher Innate immune responses are tightly regulated by various pathways to control infections and maintain homeostasis. One of these pathways, the inflammasome pathway, activates a family of cysteine proteases called inflammatory caspases...
Biochem Soc Trans (2011) 39 (2): 669–673.
Published: 22 March 2011
... are also involved in the recognition of host-derived ‘danger’-associated molecules which are produced under conditions of cellular stress or injury. Activation of these receptors leads to the assembly of high-molecular-mass complexes called inflammasomes which in turn leads to the generation of active...