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Keywords: induced pluripotent stem cellsClose
Biochem Soc Trans (2017) 45 (1): 131–139.
Published: 15 February 2017
... endoplasmic reticulum FasL Fas ligand GWAS genome-wide association studies HiPSC human-induced pluripotent stem cell IFN-γ interferon-γ IL-1β interleukin-1β KO knockout LPS lipopolysaccharide LRRK2 leucine-rich repeat kinase 2 PARK2 parkin PBMC...
David A. Parfitt, Amelia Lane, Conor Ramsden, Katarina Jovanovic, Peter J. Coffey, Alison J. Hardcastle, Michael E. Cheetham
Biochem Soc Trans (2016) 44 (5): 1245–1251.
Published: 19 October 2016
... genes often result in retinal degeneration. The ability to reprogramme human cells into induced pluripotent stem cells and then differentiate them into a wide range of different cell types has revolutionised our ability to study human disease. To date, however, the challenge of producing fully...
Biochem Soc Trans (2015) 43 (2): 302–307.
Published: 07 April 2015
..., the development of induced pluripotent stem cell (iPSC) technology offers a unique opportunity to investigate the function of Parkin and PINK1 in the disease-relevant model, i.e. human dopaminergic neurons ( Figure 1 ). Figure 1 Dopaminergic neurons derived from iPSCs of a patient with Parkinson disease...